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Old 06-28-18, 03:07 AM
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Re: All disease is preventable

Quote:
Originally Posted by Kunga Dorji View Post
So- we have 2 separate items each listed as "the point of the mind". Im struggling with understanding what you are saying here. For reference- wisdom and compassion are listed separately in Buddhist writings, and that is the only system simple enough for me to understand.

The next question is "what is this "Morality" that is apparently "out there" and needing to be acquired by us?

I do have a reasonable option for this one, as described by Antonio Damasio (neurologist).
He comments that consciousness can be regarded as a tool that the organism uses to maintain its homeostasis- get the right level of nutrition, water, warmth, etc. Human consciousness includes the capacity to create a story about this activity, one which is compelling enough to improve your motivation. The story requires a subject, a hero, hence the ego is a convenient fiction that helps you organise your life.

The trick here is that there are other egos walking about all competing for resources. So the stories told have become more elaborate, and involve others in such a way that we all get to benefit and stay alive.
Will be back to reply to both comments soon - 3 job interviews - have to somehow become an expert in the microbiome, cancer and the developmental disorder in 3 days !!
What a nightmare.
Thanks for the comments - just saw your comments on the way to post this --->---


:-)

The basis to asthma/allergy (atopy) (and many other diseases)


So - in one sentence (described below) - we're looking at distress [2] (through inherited sensitivity [1] of the sensory system) driving insensitivity/hypersensitivity at the level of human physiology (the neuroendocrine system) [3,4,5] resulting in loss of general inflammatory control and reactive appetite preference change [6] resulting in a metabolic shift altering the biome (gut then respiratory) which results in the inappropriate specific inflammatory response [11] being elicited [8,10], promoted [7] and not controlled [9].

This model connects all of the major -OMICs and medical disciplines into 1 unifying model.
-OMICs - genomics, epigenomics (transcriptomics), biomics, connectomics
&
-medical specialities - cardiology, endocrinology, gasteroenterology, haematology, infectious diseases, oncology, neurology, pathology, psychiatry, public health, renal, respiratory, rheumatology and urology.

1
Informational sensitivity (inherited condition) and high psychological 'distress'/low psychological 'eustress' (eg poverty, fear of poverty) ie distress NOT eustress in inherited stress sensitivity
->leads to->
2
'Distress' reaction when surrounded by too much information (an alternative basis to the Hygiene Hypothesis since the farm would be a low stimulation/stimulant environment)
->leads to->
3
Neuro (increased SNS activation, decreased PNS activation) Endocrine (increased stress hormone (cortisol) production)
->leads to->
4
Desensitization of SNS agonists (requiring b2AR for treatment), desensitization to glucocorticoid (requiring steroid for treatment) and Sensitization to PNS (explaining our heightened response to eg methacholine)
5
-> ie we generate an imbalanced autonomic nervous system (explaining away eg heat/cold induced asthma which call on the ANS) and a blunted response to cortisol (essential for control of the immune system)
6
-> 'Distress' leads to comfort eating (these foods activate Insulin/IGF-1 eg the takeaway which is generally a combination of starch and protein) and reduces affinity for foods without such an immediate neuroactive effect (ie soluble fibre/anti-oxidants in low GI veggies which do affect mood (95% of serotonin is produced by gut bacteria) but not in such an obvious, immediate fashion)
7
-> Pro-growth foods mixed with pro-inflammatory foods (LPS from bacteria even if killed) results in de novo synthesis of nucleosides giving us the role of theophylline (adenosine antagonist) as a therapeutic in asthma and the reason why caffeine (adenosine antagonist) dramatically increases my speed when running long distances
8
-> So - we shift into a 'growth-promoting' internal environment through shifting from veggies (gut butyrate / liver b-hydroxybutyrate) production into consuming growth-promoting/pro-inflammatory agents.
9
-> The consequence of shifting from salvage (recycling/renewal) into de novo synthesis (ie as a consequence of metabolic shift from ketosis-type into blood glucose fluctuation-type ie as a consequence of reactive appetite preference change to distress in a sensitive (CNS) individual) is that we lose access to the autophagy/apoptosis response (recycling/renewal) which in effect means that we can not deselect self-reactive (or inocuous allergen reactive) immunological cells of the specific immune system
10
-> The gut biome changes (through appetite change) and in line with the loss of control of the immune system (incapacity to access immune tolerance through metabolic shift) and priming of the immune system (through Insulin/IGF-1 promotin diet), we launch inappropriate immune reactions (involving reactive oxygen species) which manifest at the gut (opening up the gap junctions at the gut) and which lead to the shift from ROS sensitive to ROS resistant (the troublesome gammaproteobacteria) bacteria which subsequently translocate into other 'similar' areas of the body (the respiratory biome) where they drive inflammation (similarly to the gut) in their new resting place
11
-> This gives us the pattern of increased NO in exhaled air as a component of the inflammatory response in asthmatic, as NO and ROS combine to attack perceived threat.

So - in one sentence (described above) - we're looking at distress [2] (through inherited sensitivity [1] of the sensory system) driving insensitivity/hypersensitivity at the level of human physiology (the neuroendocrine system) [3,4,5] resulting in loss of general inflammatory control and reactive appetite preference change [6] resulting in a metabolic shift altering the biome (gut then respiratory) which results in the inappropriate specific inflammatory response [11] being elicited [8,10], promoted [7] and not controlled [9].

This model connects all of the major -OMICs and medical disciplines into 1 unifying model.
-OMICs - genomics, epigenomics (transcriptomics), biomics, connectomics
&
-medical specialities - cardiology, endocrinology, gasteroenterology, haematology, infectious diseases, oncology, neurology, pathology, psychiatry, public health, renal, respiratory, rheumatology and urology.
__________________
ADHD understood - simple matter of defining purpose (morality) of mind
See Stabile 'enforced moral consistency' ~15 years ago, nothing else since has been of any relevance to ADHD.
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