View Single Post
  #1  
Old 11-27-03, 01:12 AM
Salsa's Avatar
Salsa Salsa is offline
ADDvanced Member
 

Join Date: Nov 2003
Location: Iowa
Posts: 222
Thanks: 0
Thanked 20 Times in 7 Posts
Salsa is on a distinguished road
Genetic Connections Between ADHD, Bipolar Disorder, Autism, Schizophrenia, Epilepsy +

Let me preface this by saying that I didn't copy and paste this off of a website. This is information that I have gathered on my own because of multiple psychological and neurological disorders in my immediate and extended family.

~Sandy


In my immediate family exists Classic Autism, Bipolar Disorder, Epilepsy, ADHD, Depression, and (possibly) Asperger Syndrome.

In my extended family is Pervasive Developmental Disorder/PDD-NOS, Anxiety Disorder, Lupus, Multiple Sclerosis, Drug & Alcohol Addiction, and Rheumatoid Arthritis. In addition there are more cases of ADHD, Bipolar Disorder and one other case of Autism.

For this reason, I have become very interested in Neuropsychology and Genetics. Because I think/am hoping that some of what I have found will be things that others might be able to find useful/interesting, I am wanting to share it on this forum. I have my information categorized by Chromosome Bands that the disorders are related to.

I mention numerous things but bolded ADHD, Autism and Bipolar Disorder.


Chromosome Band / Disorder or Disease

1q41-42 / Systemic lupus erythematosus
1q42-q43 / Bipolar Affective Disorder
1q42-q43 / Stroke/ High Blood Pressure
_________________________________________________
4p15 / Epilepsy, partial, w pericentral spikes
4p15.3-p16.1 / Bipolar
4p16-p15.2 / Systemic lupus erythematosus
_________________________________________________
6p21.3 / Rheumatoid arthritis [RA is an auto-immunity]
6p21.3 / Celiac Sprue (gluten intolerance)
[NOTE:] Gluten Sensitivity is common in ADHD, Autism and Epilepsy
6p21.3 / Ragweed Sensitivity (Allergies)
_________________________________________________
7q31.3-32.1 / Polycystic Ovary Syndrome
(I only included this because I have a half sister with PCOS)
7q31-35 / Autism
7q32-37° / Can incude Strabismus, long eyelashes
°Duplication of the long arm of chromosome 7
_________________________________________________
10q23.3-q24.1 / Partial Epilepsy
10q24 / Partial Epilepsy w. auditory features
10q24-q26 / ADHD (ADRA2 a2-adrenergic receptor)
10q24.3 / Polycystic Ovary Syndrome
(I only included this because I have a half sister with PCOS)
10q25.3-q26.1 / Epilepsy
10q26 / Bipolar Disorder (susceptibility)
10q26 / Schizophrenia
_________________________________________________
12q22-23 / Polycystic Ovary Syndrome
(I only included this because I have a half sister with PCOS)
12q24.1 / Leukemia, juvenile myelomonocytic
(My half sister again. Survived leukemia as a young child).
12q24.3 / Bipolar
12q24 / Predisposed to Autism
12q24 / Schizophrenia
12q24.2 / Alcohol intolerance
_________________________________________________
15q11-q13
GABA-A receptor beta3 and alpha5 subunit gene cluster on chromosome band. Includes following disorder:

angelman ayndrome
autism
autistic/asperger savant skills
epilepsy
bipolar disorder

15q13-14 / schizophrenia
15q13-14 / juvenile myoclonic epilepsy
_________________________________________________
16p13 / ADHD
16p13 / Epilepsy, myoclonic, infantile
16p13.3 / Systemic lupus erythematosus
16p13.3 / Bipolar Affective Disorder
16p13.3 / Tuberous Sclerosis 2*
*TSC2 can include:Epilepsy, Autism, and effect Mental Heath
_________________________________________________
19p13.1 / Celiac Disease (Gluten Intolerance)
19p13.1 / Generalized and Partial Epilepsy*
19p13.1 / Rheumatoid Arthritis (interleukin 12 receptor, beta 1)**
[RA is an auto-immunity]
_________________________________________________
22q11-q12 / Epilepsy, partial, with variable foci (2)
22q11.2 deletion Bipolar; Mixed State & Rapid Cycling
22q11.2 / Schizophrenia, susceptibility to
22q11-13 / Schizophrenia, susceptibility to
22q13.1 / Autism, succinylpurinemic
_________________________________________________
I have much more detail as to related disorders but many of them are rare and/or what seem to be unrelated disorders

Two Examples are:
10q24-q25 / Wolman Disease
16p13 / Osteopetrosis, recessive


I avoided listing them all. If I had, this would have been an extremely long post. I can email or PM info if anyone is wanting more information, but I posted what I believe might be most pertinent.

~Sandy

Last edited by Salsa; 11-27-03 at 02:07 AM..
Reply With Quote
The Following 3 Users Say Thank You to Salsa For This Useful Post:
mctavish23 (03-25-11), Tooraj (03-25-11), zannie (03-25-11)