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Old 05-22-08, 08:46 PM
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Re: Face to Face: Adderall and Cortisol?

Quote:
Originally Posted by Iluvskittles View Post
.Increased cortisol means increased anxiety and stress.
Yeah my very first libray studying(high school 1987 or so) on my problems "Shyness" lead me to that I might have high levels of cortisol.

Quote:
1: Child Dev. 2007 May-Jun;78(3):927-37.
Links
Salivary biomarker levels and diurnal variation: associations with medications prescribed to control children's problem behavior.
Hibel LC, Granger DA, Cicchetti D, Rogosch F.

The Pennsylvania State University, Unviersity Park, PA 16803, USA.

This study examined associations between medications prescribed to control children's problem behaviors and levels of, and diurnal variation in, salivary cortisol (C), testosterone (T), and dehydroepiandrosterone (DHEA). Saliva was collected in the morning, midday, and afternoon from 432 children ages 6-13 years. Relative to a no-medication comparison group, children taking (1) antipsychotics had higher DHEA levels and flat C diurnal rhythms, (2) Ritalin or Adderall had flat T diurnal rhythms, (3) Concerta had higher T and DHEA levels, (4) antidepressants had flat DHEA diurnal rhythms, and (5) hypotensives had flat DHEA diurnal rhythms and higher T levels. Medications prescribed to control children's problem behaviors should be monitored in studies of the endocrine correlates and consequences of developmental psychopathology.

PMID: 17517013 [PubMed - indexed for MEDLINE]
That suggest Adderall does not effect cortisol levels.

Quote:
1: Pharmacol Biochem Behav. 2006 Sep;85(1):123-31. Epub 2006 Aug 23.
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Cortisol effects of D-amphetamine relate to traits of fearlessness and aggression but not anxiety in healthy humans.
White TL, Grover VK, de Wit H.

Center for Alcohol and Addiction Studies, Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02912, USA. Tara_White@Brown.edu

The current study utilized personality measures thought to relate to noradrenergic and catecholamine function (i.e., sensation seeking, anxiety and aggression) to investigate individual differences in amphetamine-induced increases in cortisol. The goal of the study was to better understand variations in responses to psychostimulants in healthy volunteers. METHOD: A placebo-controlled within-subjects investigation of salivary cortisol responses to oral D-amphetamine (20 mg) was conducted in seventy (N=70) young adults. Personality traits were assessed using the Eysenck Personality Inventory (EPI), Sensation Seeking Scale Form V (SSS-V) and the Multidimensional Personality Questionnaire-Brief Form (MPQ-BF). RESULTS: A more rapid rise in salivary cortisol after d-amphetamine was associated with SSS-V Thrill Seeking (r=-0.32 with time to peak, p<0.05). A greater peak increase in cortisol and a greater recovery after amphetamine was positively associated with MPQ-BF Aggression (r=+0.35, p<0.05; r=+0.38, p<0.05). In contrast, cortisol responses were unrelated to a composite measure of trait anxiety (EPI/MPQ-BF Anxiety Index). CONCLUSIONS: The findings suggest that the personality traits of aggression and thrill seeking are related to cortisol responses to d-amphetamine, raising the possibility that personality may predispose certain individuals to use drugs through a glucocorticoid pathway. The data also suggest a distinction between fear and anxiety, as amphetamine-induced cortisol responses were associated with measures of trait fear but not measures of trait anxiety in the current sample.

PMID: 16934318 [PubMed - indexed for MEDLINE]
Though that suggest for some people it can.
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