Adderall and Anti Virals?

[Flbravo]

I have not been able to find much helpfull information on whether or not it is safe to take these together. My primary care presrcibed the acyclovir and I do not have an appointment with my Psych for another month. Anyone had any experiences with this combination?

[Drewbacca]

Drug Interactions: Coadministration of probenecid with intravenous acyclovir has been
shown to increase the mean acyclovir half-life and the area under the concentration-time curve.
Urinary excretion and renal clearance were correspondingly reduced.
http://us.gsk.com/products/assets/us_zovirax.pdf

Drug Interactions: Acidifying agents -Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid
HCI, ascorbic acid, etc.) lower absorption of amphetamines.
Urinary acidifying agents -These agents (ammonium chloride, sodium acid phosphate, etc.) increase the
concentration of the ionized species of the amphetamine molecule, thereby increasing urinary excretion. Both
groups of agents lower blood levels and efficacy of amphetamines.
Adrenergic blockers -Adrenergic blockers are inhibited by amphetamines.
Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of
amphetamines. Co-administration of ADDERALL XR™ and gastrointestinal alkalinizing agents, such as
antacids, should be avoided. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the
concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion.
Both groups of agents increase blood levels and therefore potentiate the actions of amphetamines.
Antidepressants, tricyclic -Amphetamines may enhance the activity of tricyclic antidepressants or
sympathomimetic agents; d-amphetamine with desipramine or protriptyline and possibly other tricyclics cause
striking and sustained increases in the concentration of d-amphetamine in the brain;
cardiovascular effects can be potentiated.
MAO inhibitors -MAOI antidepressants, as well as a metabolite of furazolidone, slow amphetamine metabolism.
This slowing potentiates amphetamines, increasing their effect on the release of norepinephrine and other
monoamines from adrenergic nerve endings; this can cause headaches and other signs of hypertensive crisis. A
variety of toxic neurological effects and malignant hyperpyrexia can occur, sometimes with fatal results.
Antihistamines -Amphetamines may counteract the sedative effect of antihistamines.
Antihypertensives -Amphetamines may antagonize the hypotensive effects of antihypertensives.
Chlorpromazine -Chlorpromazine blocks dopamine and norepinephrine receptors, thus inhibiting the central
stimulant effects of amphetamines, and can be used to treat amphetamine poisoning.
Ethosuximide -Amphetamines may delay intestinal absorption of ethosuximide.
Haloperidol -Haloperidol blocks dopamine receptors, thus inhibiting the central stimulant effects of
amphetamines.
Lithium carbonate -The anorectic and stimulatory effects of amphetamines may be inhibited by lithium
carbonate.
Meperidine -Amphetamines potentiate the analgesic effect of meperidine.
Methenamine therapy -Urinary excretion of amphetamines is increased, and efficacy is reduced, by acidifying
agents used in methenamine therapy.
Norepinephrine -Amphetamines enhance the adrenergic effect of norepinephrine.
Phenobarbital -Amphetamines may delay intestinal absorption of phenobarbital; co-administration of
phenobarbital may produce a synergistic anticonvulsant action.
Phenytoin -Amphetamines may delay intestinal absorption of phenytoin; co-administration of phenytoin may
produce a synergistic anticonvulsant action.
Propoxyphene -In cases of propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal
convulsions can occur.
Veratrum alkaloids -Amphetamines inhibit the hypotensive effect of veratrum alkaloids.
http://www.accessdata.fda.gov/drugsa...303s005lbl.pdf

[keliza]

I would encourage you to call your pharmacist, if you can't get a hold of your doctor, and talk to them about it. I know at most pharmacies it is standard for them to run any new prescriptions against your current medications to check for interactions, but I don't know if that is a standard at all pharmacies. I don't see why it wouldn't be, but you could put your own mind at ease by calling to make sure.

[meadd823]

My meds are like gone so I could not read all that stuff posted above, except the intravenous stuff in the beginning. I don;t take any of my medications that way.

I have been on adderall 20mg ir I take it about four times a day and I am also on acyclovir 800mg every day - I have been taking this combination for some time - nine months.

So far so good!

I get all my prescriptions filled at the same pharmacy so when I have questions regarding the drug on drug interactions I ask the pharmacist dispensing the medications = A good pharmacist is often an over looked source for these sort of things!

[Drewbacca]

Originally Posted by meadd823

My meds are like gone so I could not read all that stuff posted above, except the intravenous stuff in the beginning. I don;t take any of my medications that way.

The short version: there are no interactions between the two classes of drugs... at least according to the official paperwork.