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Dexedrine/Dextrostat (dextroamphetamine)

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Old 10-07-04, 02:39 AM
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Im now on the Dex train

hi all, well, my doc did switch me over to dexedrine spanuals, 15mg , 2x daily. Now, there are some confusing things iv been reading about adderall and dex. Ok, i know for one, that 1/4 of adderall is D-amphetamine or (dexadrine). The other isomer is D,I racemic amphetamine sulfphate, which is basically benzedrine, used in the 1960s.

From research, the D-isomer is the supierior isomer of the 4. It causes the most mental stimulation and least peripheral stimulation. Less anxiety. More metal clarity, social enhancement, motivation. and also, correct me if i wrong, d-isomer or dexedrine is more dopaminergic, in the reward center pathways.
Now, the spanuals peak blood levels are at 8hrs. So I figure the duration of action is about 12 hrs, so when does the second dose or release occcur , about 6 hrs after?
Here is where and even my doctor didnt have a def answer, because my tolerance. Most research states that dexedrine spanuals esp at high single dose of 15mg, which is the max, are most often a once a day thing. But I told my doc, i need 16-18hr coverage, so he actually wrote me another 15mg spanual dose. I figured he would just either right me like a 20mg dose, but there is none, or a 15mg dex span, and then another regular dose of 5-10mg. But he gave me 15+15 which is a daily total of 30mg of spanuals. Now coverage being that the blood levels are high and remain steady, would be at least 16-20hrs.
I figure, that the Tmax or peak level of the drug is 8 hrs, so taking my next dose withing the 8-10 hrs range. My doc said 8hrs, take the other dose, but if im peaking around 8hrs, and somehow my body is allowing the drug to remain high for another 2-4, ill be doubleing up for 2-4 hrs in a way, at least for 2 hrs, ill really feel it, like 30mg mgs. So if you take the entire day, from say 10am i take the first dose of 15mg sp, and then at 6pm, im actually peaked, so i have a window between 6pm and to say 8pm, then take the second one, so at 2-or 4 am ,ill be peaking!. So it lookslike, even though i do stay up late, often to 5 am, all in all, i could probably have no problem staying up till 8am the next day!, just on 2 doses. But thats a long shot, and i dont think that would occurr due to the fact I was on Ritalin 30mg 3x daily, so, thats 90mg daily. THis is 30mg daily total, but in spanual form. So does and this may be confusing to me or im not getting it, 15mg spanuals, the first dose is released, and then what dose is releases after 6 hrs? another 15mg? or 7.5mg. I want to say 15mg, and 15mg, but then your looking at 30mg +30mg total for the whole day. This is what confuses me

MRES.
imgoing to see what i oculd find online or on here.
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Old 10-07-04, 10:38 AM
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thats the reason i dont extended release. im going to the dr today to get the dexedrine tabs, that way i can have a little more control over when i peak and such, also there are days when i dont need my third dose, thats the thing with spanuals, you cant decide that you dont need it as long after you dose, your then just along for the ride. but i would still think that you dr would have prescribed you a tablet in the afternoon instead of another spanual. but if you need it for 18 hours then...
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Old 10-07-04, 02:01 PM
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Spansules have beads in them of two different kinds - one type disolves right away and the other has a coating that takes around 4 hours to disolve before it releases the dose. The mix is 1/2 and 1/2 - so a 15mg spansule will release 7.5mg when you swallow it and another 7.5mg 4 hours later.
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Old 10-09-04, 11:33 PM
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THanx greg,
I was needing to know that question. That to, me doesnt seem like alot! No wonder why im not feeling much, esp with a tolerance. And if say for instance, adderall and dexedrine are like the same strength, its like taking 7.5mg of adderall, every 4or so hrs. OH boy. Even if dex is like stonger by 5-10mg, its still like taking 15 mg of adderall.
If this sound like a concept, I better like at least take 2 at a time, but then ill be short. I have 60 a month. So 4 daily, is 15 days!
Now say i called my doc , in a few days and told him, this medicaiton is not helping me at all, and is there any way to either for me to come in and get another 15 mg from you or just put me on Adderall Xr, and ill pay.
Because taking 2 daily, i know im going to take more, not because im an addict, because i want to feel better and so far im falling asleep, still, and cannot function much, but its seems to be working a bit.
Now i have 20 pills of desipramine from 1 yr ago, which may help, but thats basically a NE med. I think ephedrine would work better at a low dose mixure. Or possible taking apart the capsule and sprinkling it on say apple sauce so it hits or effect you different. Or even crush it up, but even though they say not to do this, it may kill the extended release, but in turn , they may say this so your not snorting or shooting it. Heck if people crush up ritalin LA, why not Dex. If its going to work a bit better.
But i know you cant give advise like that, but Just wondering if crushing those beads effects it.

ANyway 7.5mg . Now im really fustrated. Why do they make such a low dose, my doc seems like he was not going to give me 2, but then he said start with one and then take 2. I def have to do something, because if i loose this add effect that adderall gave me, ill end up taking alot more and running out , then im up the creeek.

MIndResearch ( I dont mean to sound like crazed, but I though it was lmore like 15mg was released every 4 hrs,or so, but to think about it, your right.
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Old 10-10-04, 10:59 AM
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You should probably focus on how this drug effects your ADD and not worry quite so much about comparisons of dosages, etc between different drugs or even different manufacturers. The question you should ask yourself is does this drug help you? Then you need to figure out what dosage actually helps you the best - and you have to be honest about that. As you get used to a stimulant, SOME of the effects go away - like the jitteriness and effects on blood pressure - but the improvements on focus don't, so if you are judging the effectivness of the drug by the way it makes you feel - ie. the "buzz" - you may not be gauging the effectiveness correctly. Tolerance to these drugs is often misunderstood for the same reason. While some tolerance will develope in some people, it doesn't manifest itself like narcotics, where tolerence develops fairly quickly, for everyone, for all of the narcotic effects. You usually don't see ever increasing doses for amphetamines, unless the person is chasing a "high". In thereaputic use, there will be an equilibrium point, so to speak, where the dosage will stay stable from both the standpoint of effectiveness and quantity.
And as for crushing the spansules to make them "instant" release - again, it's not something I'd recommend - you'd get very uneven dosing, since there are going to be beads that don't get crushed, and what would be the point - If you want regular release, I'd ask my doctor for it.
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Old 10-10-04, 12:33 PM
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Thanx greg, your correct, i guess my "add" is back a bit because i seem more "figity" and worrysome. I imagine the switch from adderall to dex, i had very high hopes, but i know you cant look at it like that. But i know the "effects" such as focus motivation, are still not as good as the adderall, but like i said, ill give it some time. But, when i heard the 7.5mg thing, i sorta was like oh no!, thats low. But i sorta understand the reason why , because I did tell my doctor that ADDERALL was wearing off and not giving me a full day of releif, so. I do imagine my next appointment he will add some or another Regular dose, would be nice. Im not sure the exact potency or if dex=Adderall, but i always thought it was maybe 10mg stronger. But I do notice more of my symptoms , so thats a negative, with adderall, even though the feeling went away, i still felt good enought to be motivated, etc. Ex. doing work online and reading for 8 hrs, with breaks. I never did that before. Or i would be doing useless stuff like watching TV all day, or driving around , going to bars.
Now basically I work out, do alot of research, not just on drugs or add, but supplements and trying to look into setting up a small business. Plus i dont sleep alot, maybe 6 or 7 hrs, but that day i took my dex, i slept like 8 hrs!, and then some. Then i was still groggy. So, right there either it was because i was sick , but im better now, so well see how this pans out.
I must admit due to my addictive personality, I would not mind that nice feeling. But its not a high, like opiates or it does not cause problems in my life (so far), and its working very good on my mental status.
Now, self medicating, which alot of people do, i used to do for 4 yrs. Everything was drink this or take that so i can go out, but these drugs were "hard", GHB and OXYS are like very bad, addictive mentally , physically , and both alter the dopamine system, but somehow they do for the hour or so there in me, elieviate my mental issues. BUT thats drugs for you.
Iv been through it, 2 rehabs, actually was thinking about being a counselier, just have to get my CAC. Because most counsielers in Rehabs are ex addicts, which you can relate much better. But the funny thing, i remeber, was a girl who was in there with me, was in like and i asked her what meds does she take, and she said adderrall. I said WHAT! IN HERE! SHe said , oh well i have severe add and i must take it, so i guess because ADD could be considered a devistating problem without meds, they allowed her to take it, but not dispense it herself, all meds were given by an administrator.
I tend to get in a crave situation when i worry or i dont feel up to par, then its a revolving circle in my brain, so, am i concerned about dexedrine working . Very much so. Do I expect to get that buzz like the first week of adderall, NO, but I did think making a switch to DEX would have , so my hopes were up to high from listening to others say its the best drug for add and this and that. You seem to know your stuff, ever think about counseling people, esp ADD?
I dont have at least 1 full yr clean so, i would not risk being around other people talking about street drugs. But it really doesnt bother me, some people it does, but i feel better if its on my mind and i speak about it , even online.
I also tend (which is not bad, but sorta a bit odd), that i love to study the neurotransmitters, and how drugs and supplements effect them. It could be and probably is alot to do with my drug and alcohol issues, and i feel i have alot to offer, but focusing on getting better and not worrying about well lets see, ill take this amount, no thats not working, take this, that can lead me back to the ol oxy farm. I actually had to shut most of my old friends out, because when you get sober, they dont want to see you sober for some odd reason, esp when there using. You will tell a friend, even if you were the nicest guy to him , that your clean , and this and that, and the first thing they will say is, OH I GIve him a week or a month, or hes using still, Klonoopin adderall,, etc, its the same.
NOw i can go on about this and i wont because a counslier in rehab , would say 2 cups of coffee is drug behavior. But they dont know the mental aspect , esp dual diagnoses , well at least most dont. They may think they know how to talk and tell you do this or that, but that does not work at all. If you tell someone dont take 5 pills a day , 10 people can tell me, and i wold take 10 in the next 30 min,when i was using. But To rap this up, I will do my best to focus on my symptoms and give it a week, if i get worse or not much better ,ill call him and see what can be done.
ANd taking other drugs like sometimes i do post , when im in these moods, trying ot offer what i think may help, most often doesnt work. Its hit or miss. Addiction varies, i dont believe just because you abuse one drug you will abuse evey one. I still have 3/4 of my klonopin left, which iv had for 15 days, and I live above my fathers bar for example where there is more beer and liquor to get 10 elephants drunk, and i have no cravings at all
So i narrowe it down, ALcohol G, andOPiates all constantly bombard the reward system in the brain, and iv ben reading some files on Brain reward syndrome and adddiction,and like add and dopamine. But often i get confused, because im not a psychiatrist or some specialist in brain chemistry. So from posting alot on a mental health forum for 3 yrs, which i will not say due to respect of the board, most eveyone or at least half talked psychopharmoclogy , or you would post a question like, Im getting panic attacts from adderall? wel the answer you get is, well deep in the brain, lyes the amyglia, which interacts with Gabaenergic neurons , via sodium and calciaum ions ETC< now some person who doesnt know what serotonin is, woudl be like lost and probably never come back. So , i try to be more self explanation, instead of reading or talking like a neuropsychiatrist.
thanks
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