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Dexedrine/Dextrostat (dextroamphetamine)

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  #1  
Old 04-14-19, 11:54 AM
andy1027 andy1027 is offline
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Alternative to SNRI for anxiety

I take Dex for ADHD. But I also take 30mg Cymbalta for anxiety, anxiety which is increased somewhat when on the dexamphetamine.

I want to get off the Cymbalta due to some side effect(s). I was wondering if there is any alternatives to using SSRIs or SNRIs for treating anxiety? Could beta blockers be effective?
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My ADHD sometimes looked like innatentive type, but I feel that this was because of the untreated anxiety.
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Old 04-14-19, 08:29 PM
kobefan234 kobefan234 is offline
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Re: Alternative to SNRI for anxiety

propranolol was the only beta blocker that was effective for my anxiety. its lipid soluble and crosses the Blood Brain Barrier. watch out for Bradycardia
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Old 04-14-19, 09:13 PM
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Re: Alternative to SNRI for anxiety

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Originally Posted by kobefan234 View Post
propranolol was the only beta blocker that was effective for my anxiety. its lipid soluble and crosses the Blood Brain Barrier. watch out for Bradycardia
Do you take it alongside dexamphetamine?
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My ADHD sometimes looked like innatentive type, but I feel that this was because of the untreated anxiety.
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Old 04-15-19, 01:34 AM
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Re: Alternative to SNRI for anxiety

Clonazepam. (benzo, not beta blocker.)

Preach it!
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Old 04-15-19, 12:32 PM
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Re: Alternative to SNRI for anxiety

Some say that Vitamin D3 is helpful with mood and anxiety.
And some find that CBD oil has been helpful for anxiety.
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Old 04-15-19, 10:38 PM
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Re: Alternative to SNRI for anxiety

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Originally Posted by andy1027 View Post
Do you take it alongside dexamphetamine?
I have done that once or twice. I had a bad experience one time when combing the two medications. I started to feel light headed and dizzy. Could have been two Autonomic Nervous system agents each doing opposite effects.
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Old 04-16-19, 08:40 AM
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Re: Alternative to SNRI for anxiety

For more than 10 years I was treated by three GI doctors for acid reflux. Each one prescribed megadoses of proton pump inhibitors. My symptoms continued unabated. I had endoscopies, motility tests and other tests, costing me thousands of dollars. Meanwhile, my symptoms worsened. I went on the Internet and did lots of research. I learned about gluten-related neurological symptoms, and how avoiding gluten can improve mental health. I stopped eating food with gluten for a week and drinking shilajet tea. My symptoms disappeared. I have been gluten-free for four years and feel like a new person. Not one of the doctors who I saw ever suggested that gluten might be my problem. I should have sued them all for malpractice. Thank goodness for the Internet.

Last edited by namazu; 04-16-19 at 09:49 AM.. Reason: Removed links to commercial websites. Please see ADDF guidelines.
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Old 04-16-19, 01:35 PM
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Re: Alternative to SNRI for anxiety

My doctor just prescribed me Trintellix 5MG in addition to my Dexedrine Spansules. It's not technically indicated for anxiety, but it is indicated for MDD / Depression. I failed on all other SSRI/SNRI's like Luvox, Buspar, Wellbutrin, etc. and it seems to be helping a lot with my anxiety and even OCD symptoms. You may want to ask your doctor about Trintellix.
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Old 04-16-19, 01:49 PM
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Re: Alternative to SNRI for anxiety

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Originally Posted by rochers View Post
For more than 10 years I was treated by three GI doctors for acid reflux. Each one prescribed megadoses of proton pump inhibitors. My symptoms continued unabated. I had endoscopies, motility tests and other tests, costing me thousands of dollars. Meanwhile, my symptoms worsened. I went on the Internet and did lots of research. I learned about gluten-related neurological symptoms, and how avoiding gluten can improve mental health. I stopped eating food with gluten for a week and drinking shilajet tea. My symptoms disappeared. I have been gluten-free for four years and feel like a new person. Not one of the doctors who I saw ever suggested that gluten might be my problem. I should have sued them all for malpractice. Thank goodness for the Internet.
I can appreciate what you feel gluten free has done for you and that it works but generally-most people that believe they have an issue with gluten-especially as it pertains to gluten intolerance-actually have an issue with something else. At least when it comes to physical gluten intolerance there is really only a smaller subset of people with celiac disease and if you are gluten intolerant you have celiac disease. Some people say in general that PPI's make their digestion issues worse and once they stop those things get better. I have tons of gi issues including Barretts espohogus and I take a PPI. I also have a "looping" bowel.(so funny sounding to me)I try and read all I can about issues related to that. IME I haven't found a whole lot about neurological functions and gluten or gluten free. Can you share something with me? Because I truly am curious if it would help me but all I have explored on the gluten front has not lead me to the same conclusions that you have but I am open to learning.
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Old 04-16-19, 01:53 PM
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Re: Alternative to SNRI for anxiety

OP- I take cymbalta but I also take Buspar:
Quote:
What Is Buspirone And What Does It Treat?
Buspirone is in a class of medications called anti-anxiety medications. Buspirone is not related to other anti-anxiety medications, such as benzodiazepines, barbiturates or other sedative/ anxiolytic drugs. It is approved for the treatment of generalized anxiety disorder (GAD).It may take 3 to 4 weeks before you start to feel better. Initially you may begin to notice a decrease in irritability and worry. Unlike other anti-anxiety medications, buspirone has very low abuse potential.
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Old 05-13-19, 12:58 PM
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Re: Alternative to SNRI for anxiety

I had been on the lookout for something healthier than an SSRI/SNRI/TCA for an antidepressant for quite some time. The best I could find was a curcumin BCM-95 extract.

Since then however I have discovered polygala tenuifolia. It is a reversible MAOI, increases memory and cognition via several mechanisms including verbal and spatial memory, increases BDNF/NGF (helpful in general but also for any mental illness as it shrinks your hippocampus and those two regrow new neurons in that region), decreases inflammation (another way typical antidepressants exhibit their effects besides neurologically and through BDNF), modulates NMDA and is an NMDA antagonist (one of the main methods of its antidepressant effect... Same rapid onset and similar if not identical mechanism of action to ketamine's antidepressant effects... Also reduces tolerance to stimulants via these effects on NMDA), repairs HPA Axis and regulates cortisol (helpful for PTSD type stuff), anticancer, helps with excitotoxicity from dexedrine via adenosine A2R agonism, reduces/eliminates anhedonia, plus all sorts of other helpful things.

You can check out examine.com and selfhacked.com for more info.


So far I like it a lot more than any antidepressant I've taken. I've taken nardil and it reminds me a lot of that in terms of anxiety reduction and antidepressant effects.

The lack of cognitive impairment/emotional blunting/apathy compared to SSRI/SNRIs is very evident which is why I prefer MAOIs over the former.

https://www.ncbi.nlm.nih.gov/m/pubmed/24520403/

"These findings serve as preclinical evidence that Radix Polygalae extract exerts rapid-onset antidepressant effects by modulating glutamatergic synapses in critical brain circuits of depression and may be worthy of further evaluation as a safe substitute to other rapid-onset antidepressants known to have unacceptable side effects."

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3919798/

"The rodent study presented here suggests a rapid-onset antidepressant-like effect of RP in concert with AMPA receptor modulation but not mTOR phosphorylation in the hippocampus. Currently a rush to develop novel antidepressants is ongoing at both the preclinical and clinical stages. RP is a common remedy that is still widely prescribed by practitioners of traditional medicine. RP may possibly substitute for other rapid-onset antidepressants like ketamine that are associated with addiction risk and unacceptable side effects. It will be worthy to further evaluate the pharmacologic effects of RP and especially its constituent parts as candidates for novel antidepressant development."

If it was something like that curcumin extract I'd say okay you might need something stronger. However tbh this stuff is working more strongly than antidepressants do for me (including wellbutrin and mirtazapine). Plus it's pretty cheap. $20 for 3 months is really cost effective.

It's antidepressant effect definitely kicks in much more quickly than typical antidepressants but you do get even more of an antidepressant effect (due to the MAO inhibition) after a month or so.

Also magnesium taurate helps produce gaba and the magnesium increases the effects of dexedrine while simultaneously decreasing tolerance via NMDA antagonism. It also helps to wait 10 minutes or so to take dexedrine after you take your magnesium as it lowers the pH of your stomach and increases absorbtion (nothing nearly as dramatic as tums though so don't worry).

Also something really effective for short term anxiety relief is the honokiol extract from swanson (200mg 90%+ version). It is a gaba a agonist (like benzodiazepines) and a positive allosteric modulator. I take it for sleep and each pill literally feels identical to a 15mg temazepam for me. I would get it from swanson themselves to save money as opposed to Amazon.
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Old 05-13-19, 06:35 PM
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Re: Alternative to SNRI for anxiety

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Originally Posted by sarahsweets View Post
At least when it comes to physical gluten intolerance there is really only a smaller subset of people with celiac disease and if you are gluten intolerant you have celiac disease.
I have no idea if those I know who feel better gluten free are called gluten intolerant or if a different label is more appropriate, but I certainly know people who have eliminated gluten and feel better, with less bloating and nausea. Since there is no test for this more mild reaction, I think the only way to test for it is to eliminate it from your diet for a month or two and see if you feel better.
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Old 05-13-19, 08:38 PM
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Re: Alternative to SNRI for anxiety

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Originally Posted by qanda View Post
I have no idea if those I know who feel better gluten free are called gluten intolerant or if a different label is more appropriate, but I certainly know people who have eliminated gluten and feel better, with less bloating and nausea. Since there is no test for this more mild reaction, I think the only way to test for it is to eliminate it from your diet for a month or two and see if you feel better.
Gluten intolerance includes, but is not limited to, Celiac's Disease.
Several Wiki pages discuss this.

I might feel better if I stopped eating breads and pastas, but I would not be happy.
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