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  #136  
Old 07-12-18, 05:41 AM
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Re: All disease is preventable

A key aspect of the pattern (from the three prevention threads)

DISTRESS <-too little eustress too much-> DISTRESS

So we've covered this in the neurone.
Too little activation - deletion
Too much activation - deletion

And more recently in autophagy.
Autophagy increases likelihood of life (repair) and also likelihood of death (recycling) ie there's a mid-point between two extremes which we're striving towards - the middle way.

And here it is again.

Quote:
Impaired mitochondrial function often results in excessive production of reactive oxygen species (ROS) and is involved in the etiology of many chronic diseases, including cardiovascular disease, diabetes, neurodegenerative disorders, and cancer. Moderate levels of mitochondrial ROS, however, can protect against chronic disease by inducing upregulation of mitochondrial capacity and endogenous antioxidant defense.
https://www.ncbi.nlm.nih.gov/pubmed/29607218

Simple language.

A little is required for health
Too little / Too much - results in a poor outcome.

-*-

Yes - but what people want to know - is how they can be sure that they're in the sweet spot ie neither too much nor too much exercise, neither too much nor too little food intake ... ...

EASY

As soon as you are free to choose (ie have nobody telling you what you should do) - then your own appetite regulatory processes will place you in the healthful centre of the distribution.

If we're in a co-ercive environment then we either do not want to have a go (for fear of being attacked as happens in science whenever you present findings to rapacious bosses in scientific disciplines) or you need to turn the handle 24/7 in order to generate a huge amount of data to satisfy your rapacious bosses in a scientific environment.

-*-

What am I suggesting ? Whether you're a formal scientist or not - there is NO scope for hierarchy in the human species. Social and medical epidemiologists Wikinson and Marmot have provided data to this effect.

As long as hierarchical organizations are supported - they will be kept in place for reasons of people in the hierarchy gaining more power (money/fame) - and not in any way have anything to do with the social benefit which they hide their existence behind.
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  #137  
Old 07-12-18, 05:46 AM
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Re: All disease is preventable

Categorically - there is NO need for
- the medical establishment if we prevent disease
- the life science (a very large chunk) research community if we prevent disease
- the legal system if people embrace morality
- the banking system (like law) is a method of enforcing hierarchy - both dissolved through generating a flat structure of man
- the agrichemical industry - falls to permaculture and aquaponics ie we need natural sustainable approaches to food generation not chemical based approaches which sterilize and poison the soil


There is NO workplace sector remaining however this does not mean that we won't still have a cloud server which people can connect to with a simple device - the human body connects via the neuro endocrine system - the species will connect via the internet (neuro - fast) and some sort of guided electric bus (endocrine - slow) system.

-*-

So automated house and food generation.
All people with access to one another (information + travel if necessary).
And then with reference to specialist trainign schools - want to learn something then 'move' to a specialist school - if it's surfing - then your school will need to be geographically located next to a sea with sun and waves.

Learning specialist centres based around the geographical requirements of the speciality.

Surfers need sea.
Mountaineers need mountains.
Ultramarathon runners need countryside.

-*-

Education has not been about understanding/morality and quality ie all people becoming a scientist/social scientist adn artist
- and instead has become like 'Real Madrid or Manchester United' - simply having enough money to buy in talent who have access to much money to buy in high impact factor rating paers.

Anybody can solve ANY and EVERY problem that human beings have through the use of a little observational data (your eyes) and your mind.

Don't need 'data science', super computers or artificial intelligence - one simply needs eyes and a period of reflection to organize observational data into sense/understanding.
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  #138  
Old 07-12-18, 08:54 AM
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Re: All disease is preventable

I have to ask SB_UK


You put so much effort into these interesting topics, but I think hardly anybody takes the time to read through them. Why do you expense so much effort into making these types of threads?
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  #139  
Old 07-12-18, 09:18 AM
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Re: All disease is preventable

Quote:
Originally Posted by Fraser_0762 View Post
I have to ask SB_UK


You put so much effort into these interesting topics, but I think hardly anybody takes the time to read through them. Why do you expense so much effort into making these types of threads?
I've referenced them (request that people search on SB_UK and preventable) from other sites eg BMJ.

I'm waiting for somebody to come up with a rational counter-argument.

As if it's any good - then I'm going to have to work hard to encapsulate it.

I don't believe that any disease will be harder to throw at this idea though than the monogenic developmental disorder - which is the 'watershed' disease type - in that nobody has any doubt that

T2D/Obesity is preventable.

Though T2D -> Alzheimer's was a good connection (some people call Alzheimer's T3D apparent when we look at amyl[amylase starch digesting]oid plaques)

T2D/Obesity -> Cancer also [an early epidemiological finding].

Cancer (somatic mutation) -> Developmental disorder (arising through similar process) [this follows on naturally as they're both error checking failures]

(di)Stress -> Psychiatric disorders (increased sensitivity) [reasonably obvious]

So - we've:

(di)stress -> comfort eating -> T2D/Obesity -> Alzheimer's/Cancer
(di)stress -> comfort eating -> Developmental disorder (error checking failure exactly as we see in Cancer ie 2 hit hypothesis)
(di)stress -> psychiatric disorders (sensitivity in an insensitive environment)
(di)stress -> inflammatory/immune disorders (why steroid is used to treat inflammatory disorders)
(di)stress -> steroid resistance -> susceptibility to infection (eg the common cold)


There's nothing wrong with ADDer (a comment made often over the last 15 years) - we've a core issue (a positive) - with sensitivity which breaks in an insensitive environment.

The ADDer only breaks (procastinates and fails) when made to engage in tasks which the ADDer does not want to do (ie no reward) - all we're required to do is work out what an ADDer does want to do.

And therein lies the purpose of this website.

The difference between ADDer and nonADDer is that there's a different profile of activities which're rewarding (ADDer wants to become of ever higher quality in a collective environment where everybody becomes of ever higher quality) - and so we break in the current environment where nobody's becoming of ever higher quality.

The commonality though is distress.

And the root cause of the distress is that human beings have failed to realise that the mind is meant to be a personal repository for morality ie to confer (eventually) wisdom.

So ... ... ....

mind minus morality -> tries to accumulate money and power -> competes with others and makes self and others distressed -> the chain of events above then follow on ... ...
Quote:
distress -> comfort eating -> T2D/Obesity -> Alzheimer's/Cancer
distress -> comfort eating -> Developmental disorder (error checking failure exactly as we see in Cancer)
distress -> psychiatric disorders (sensitivity in an insensitive environment)
distress -> inflammatory/immune disorders (why steroid is used to treat inflammatory disorders)
distress -> steroid resistance -> susceptibility to infection (eg the common cold)
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  #140  
Old 07-12-18, 09:28 AM
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Re: All disease is preventable

I actually agree with your take on this. But you've put so much information in here, that it is unlikely that people are going to take the time to read through it all.



If things were categorized better, I think it would make it a bit easier for people to get the areas of the topic that interest them.


Judging by your informative posts on here however, I believe you'd be great at writing books that challange the current status quo of available information.
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  #141  
Old 07-12-18, 09:32 AM
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Re: All disease is preventable

Quote:
Originally Posted by Fraser_0762 View Post
I have to ask SB_UK


You put so much effort into these interesting topics, but I think hardly anybody takes the time to read through them. Why do you expense so much effort into making these types of threads?
I'm hoping that there's at least one person who wants to know what ADHD is.

Stabile (on site) had worked all of this out.

All that ADHD is - is 'informational' sensitivity - we're learning (to handle information) habituated. Information handling is foisted in us - and we go mad unless we attempt to handle (understand reality / recognize sensory streams) which we're immersed in.

So - if anybody gives ADDer observation - we need to reconcile it.
How does it fit in ?

What doesn't make sense ?
No - it all makes sense - we're simply in the middle of the emergence of a novel species which has increased informational sensitivity - where the basic mechanism has been worked up by Henry and Kamila Markram.

Now - could we have worked out that the ADDer was information sensitive ?
Personally - I can't handle loud noises, 'rough' clothes (eg clothes labels), horror movies, roller coaster rides - they produce an overwhelming level of information which I inactivate under - and so yes - it was possible to work ALL of the above out without any level of molecular dissection.

We didn't need to peer inside the body to work out why people become sick.

But as we have - we can extend the model into proving that distress generally deranges the key systems which medical research concentrates upon.

Distress -> genomic dysfunction, mitochondrial dysfunction, gut biomic dysfunction, connectomic dysfunction, glycomic dysfunction etc ie we can validate destruction of the systems within the body through (di)stress - but there was never any need.

Now - the problem is - that nobody wants to change their lives from choosing their own premature demise (to diet, stress, alcohol, cigarettes) - and so what's the point in connecting molecular mechanism to epidemiological mechanism ?

Thing is - is that the model offered begins with one observation.

ie - recognize that the mind was supposed to confer morality which results in wisdom on an individual -> on a collective level -> nature reward system change -> preference for a lifestyle which does not curtail quality of life.

But you're suggesting that the epidemiological / molecular data wasn't of any use ?

However - the counter-argument is that arrayed epidemiological / molecular data can be used to define a moral (rational mind) ie stage 1 in
Quote:
the mind was supposed to confer morality which results in wisdom on an individual -> on a collective level -> nature reward system change -> preference for a lifestyle which does not curtail quality of life.
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  #142  
Old 07-12-18, 09:41 AM
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Re: All disease is preventable

Quote:
Originally Posted by Fraser_0762 View Post
I actually agree with your take on this. But you've put so much information in here, that it is unlikely that people are going to take the time to read through it all.



If things were categorized better, I think it would make it a bit easier for people to get the areas of the topic that interest them.


Judging by your informative posts on here however, I believe you'd be great at writing books that challange the current status quo of available information.
Biomedical scientists are misleading people into believing that there will be a cure to man's problems - we're in the midst of a delusional believe in precision personalized medicine.

Some of these people need to get out of their offices and take up some of the raw data files that their slave researchers are generating - human beings are REALLY complicated - we're never going to fix a broken human being. We can't even fix my broken car and we built it - and it's simple to build ... ...

We can though stop a human being from breaking in the first place.

Biomedical research can generate an infinite amount of data - I could bankrupt the planet with the experiments I want to do - it would not be hard.

Luckily - none of those experiments are necessary.

All that we're required to see is that we haven't used the mind properly in that there's meant to be a direct connection between anything we know and rational objective morality.

So - take a look at the weapons industry, cigarette industry, processed food industry, sugar industry, clothes industry, sports industry, running shoe industry etc taking in all industries - although the systems which these industries use are complicated - there's no direct connection between the system of logic which they use and objective rational morality.

So - that's really all there is to it - don't do anything unless there's a connection between one's system and a better world for one and all.

This one idea is enough as a summary to all of my posts on site.

And that's the problem with writing a book on the subject - I can summarise the entire idea in 1 sentence.
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  #143  
Old 07-12-18, 09:50 AM
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Re: All disease is preventable

Psychiatric disorders may be controversial

This set came through thanks to Lunacie.

[1] Autism - not failure to handle information (empathy) but overloaded by information via the empathy channel <- Lunacie comment
[2] ADHD - sensory information sensitivity (described above in my case)
[3] Schizophrenia - see autism but in systematizing not empathizing

So Simon Baron Cohen legitimized empathizing-systematizing as model - combine with Barliman's mention of HSP (highly sensitive person) -


- and the psychiatric disorder gives way.

ie sensitivity to systematizing, sensory and empathizing information

Autism (male (not gender) archetype) --- ADHD --- Schizophrenia (female (not gender) archetype)

ie we derive a basis to overcoming majority developmental disorders and psychiatric disorders and rip the neurologist and the psychiatrist apart. The two were supposed to be studying different evolutionary abstraction layers - but couldn't because neither tried hard enough to work out what the problem is.

So - we can also dispense with a large part of neurology as secondary to metabolic research ie the research I've pointed out that there's no Alzheimer's and Parkinson's on Athos ie neurological dysfunction is secondary to metabolic derangement occurring through dietary change based around distresses which human beings (through the lives they lead) (courting hierarchy) generate.
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  #144  
Old 07-12-18, 09:58 AM
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Re: All disease is preventable

Quote:
Originally Posted by Fraser_0762 View Post
But you've put so much information in here,
Here's the simple summary.

Quote:
Don't do anything unless there's a connection between one's system (what one does) and a better world for one and all.
So we simply need to become well versed in vested interest ie the usual suspect who states that {something in the best interests of the individual eg buying double glazing from the person at huge markup} is in your best interests.

How do you work out whether they're actually speaking objectively rationally ?

It's not entirely simple in some areas - so for instance is wine good for you ? is it OK to have meat once a week ? would it matter if one smokes near to children ?
However - one can deconvolute all of these problems if one tries.
Alcohol, Meat and Smoking (just random examples) preference dies with moral nature acquisition (wisdom) because the itch they scratch no longer exists.

-*-

So - the question becomes - how do we change appetite preference from hastening our own premature demise (to lifestyle narcotics and stimulants) to increasing longevity/quality of life ? And the simple answer is that human beings have failed to spot that the human mind had a purpose and that was for all human minds to embrace morality - to have a definition of objective rational morality for themselves - that this hasn't happened and that the net consequence was for all individuals/the collective to collapse under problems - of which disease is only one. Our problems don't stop with disease but include so many other areas including the generation of a planet which will be uninhabitable for future generations - because nobody is thinking about anybody other than themself. Human beings are simply a part of an evolutionary flow - in which novel more complex structures are to be imagined to be generated if we look at what has happened in the past.
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  #145  
Old 07-12-18, 10:15 AM
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Re: All disease is preventable

Quote:
Originally Posted by _ View Post
So - the question becomes - how do we change appetite preference from hastening our own premature demise (to lifestyle narcotics and stimulants) to increasing longevity/quality of life ?
General idea then at birth need stimulant / narcotic (eg milk contains stimulant (lactose) and narcotic (casomorphin) ie stimulant/narcotic combination (see wikiP/speedball drug) drives reward.

Goal - to derive sensitivity to stimulant/narcotic through mind of morality and not resistance (through cranking the handle of stimulant/narcotic behaviours).

From this we see that we create our own problems by living in a system in which money (reward system of stimulant) generates resistance to associated neuroendocrine factors - where the goal is sensitivity (sensitivity occurs by distancing oneself from 'drug' here money./power) ... ...

Simplifying again.

The natural tendency I'm describing isn't really anything to do with money/power but the internal consequence of money/power acquisition which is the same as increasing levels of stimulant taking (high levels of cocaine for instance) - in that resistance syndromes (tolerance) - the need for ever more to generate the same level of reward results.

I'm thereby describing

mind + morality -> wisdom and appetite preference change to sensitivity to stimulant/narcotic endogenous correlates resulting in pain when attemped ie sensitivity -> painful hypersensitivity.

-*-

Once again simply.

Simply educate one's mind to objective rational morality (question everything) and one's 'tastes' change from addictive substances to learning ever increasing personal quality (to becoming intrinsically better).
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  #146  
Old 07-12-18, 10:23 AM
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Re: All disease is preventable

Just had a look - looks like these ideas are going mainstream

autism
'Too Much Information (TMI) is a campaign delivered by The National Autistic Society'
"Why Too Much Information?"

adhd
Often, people with ADHD are also highly sensitive to environmental stimuli.
"Highly Sensitive and ADHD"

schizophrenia
"It makes sense that the result of too much information and/or stimulation should result in disorder (a disorder of disorder)."
https://motherboard.vice.com/en_us/a...ruled-by-genes
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Old 07-12-18, 10:28 AM
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Re: All disease is preventable

So ................................

What remains to be said ?

Simply - the psychiatric disorders represent sensitivity to information in 3 channels.

Unless that heightened sensitivity is handled (the individual can withdraw when they need to) - the heightened sensitivity leads to distress to disease as described above.

Now - the only mechanism of an individual being able to withdraw when they've had enough would be a voluntary system.

If you're stressed out at work and want to go home - you can't or you'll lose your job.

Sooooooo - what we have in order to handle evolutionary change in man (ie emergence of sensitivity in systematizing, empathizing and sensory channels) is simply a society in which all people are given what they need to survive for free though all inclusive co-operative formation.

That's it really - the solution to psychiatric disorders would be the arrival at a fair global society in which all people work together to generate what they need to survive - and then choose their own path in life.


-*-

The whole of the medical research, molecular research, biotech research, pharmaceutical research is a complete load of nonsense
at least if making healthy people is the goal. None of the data generated is 'wrong' as such - it's just of no utility in making the species healthy.
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Old 07-12-18, 11:32 AM
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Re: All disease is preventable

I'm forever getting into trouble for suggesting that the mass of data generated by medical research is of no use.
Will it prove to be of use ?

So - here's the problem - take a car - how many different shapes can it be bent into after a crash ? It can be deformed in an infinite number of ways dependent on how the crash occurs - from the front ? the back ? a piano from above ?

Now - cancer research (eg https://cancer.sanger.ac.uk/cosmic/about) provides a breathtaking array of variants with some connection to cancer.

It has taken lots of research, lots of time by people sequencing and analysing sequence, lots of programming, lots of data entry - it's a really big deal.

But we all know that - there are two types of science - 'stamp collecting and physics (mechanism)' ... ... the goal isn't to define the mechanism of cancer - wayyyyyyy! too difficult and too variable but to define the mechanism of prevention - which is trivial.

Access autophagy through lifestyle and we can clean ourselves.
That's all there is to it - and the chap who runs COSMIC should know as he's in charge of 'Cancer, Ageing and Somatic Mutation' ... ... ie if we can find a way of managing ageing then we'll find a way of managing somatic mutation ie cancer (and developmental disorders).

How can we manage ageing ?
Everybody knows

Quote:
Calorie restriction (CR) extends life span and retards age-related chronic diseases in a variety of species, including rats, mice, fish, flies, worms, and yeast. The mechanism or mechanisms through which this occurs are unclear.
https://academic.oup.com/ajcn/articl...dFrom=fulltext

What's the mechanism ?
Easy - shift from carb to ketone (anti-oxidant) generation, pro-mitochondrial, suppresses ROS production, reduces DNA damage whilst increased autophagy (low N and C foods ie protein + carb respectively) results in autophagy (first repair and then recycling).


It's soooooooooo easy.
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Old 07-12-18, 11:44 AM
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Re: All disease is preventable

What is amazing is that only '2 hits' can result in cancer - and that they don't happen regularly. What is remarkable is that the system can resist transformation into cancer.

The entire genome grew up in an environment of having not particularly much to eat - and when it did get something to eat - it'd be fresh food - be it animal or vegetable.

And that's the secret to overcoming cancer - eating a little of real (has to be vegan as there aren't enough animals to go round) food.


The system needs to be free to clean itself on the inside - it can't do this unless we acces autophagy.

Yes - science is terribly clever in that we're able to generate lovely shiny web apps which allow us to list out all of the mutations associated with some cancer at some stage ... ... and the genomic variants scroll down in what seems like forever in front of our eyes - but at some point - somebody's going to have to ask - where's the human health benefit to the MASSES of data we've accumulated.

There is none.

We can not arrive at human health through describing in meticulous detail EVERY single change that occurs upon disease.

We simply need to work out how to prevent the chain of events occurring int he first place.

And the causal aetiological basis to all problems of man - would be the absence in individual/collective morality. In people failing to realise that the measure of intelligence is morality nature - and that the end-point of intelligence is wisdom.

If the mind knows plenty about deeply abstruse and sometimes phenomenally complex mathematical systems - which do not make life better for people - well what's the point ?

So - sure you've a string of qualifications on your CV in the subject - but what you know is of no greater utility than a compendium of the length of grass to picometre in my back garden.
An impressive feat - but why bother ?
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Old 07-12-18, 01:44 PM
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Re: All disease is preventable

I'm hoping that there's somebody alive who can see the need to do something about human suffering.


Sadly all that I can see in (the) healthcare (industry) are people cashing in on suffering.


Really no human being cares about anybody else - they all (AS IN EVERYBODY) just want your money.


How do I know ? Because when one overcomes the love of money - aversion sits in its place ie you feel a sense of pain (and cannot concentrate) in the workplace.


Nobody with wisdom would be able to contribute to infinite data generation knowing that the exercise prevents people from doing anything about suffering.

If your experiment does not solve any of man's problems - then 'obviously' we simply need to do the experiment again with more people.



Quote:
“the definition of insanity is doing the same thing yet expecting different results.”



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Last edited by SB_UK; 07-12-18 at 02:09 PM..
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