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  #46  
Old 05-23-18, 07:16 AM
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Re: All disease is preventable

So - a generalized pro-inflammatory environment gives rise to disease.

Multiple causes - but the single aetiological basis is failure to develop moral mind within a collective environment of morality (wisdom).

EVERY SINGLE DATAPOINT CONVERGES ON THIS MODEL.

We can define them all but - there's no actual need to.

What is sequencing the genome useful for ?
Proving that it won't take us anywhere useful.
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  #47  
Old 05-23-18, 07:31 AM
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Re: All disease is preventable

Was all of this obvious ?
Yes - simple epidemiology of

obesity -> cancer
+
T2D -> Alzheimer's disease

that anybody could do with a clipboard and a fraction of a brain.
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  #48  
Old 05-23-18, 07:36 AM
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Re: All disease is preventable

Quote:
Originally Posted by google
Despite the absence of a hospital, studies show life expectancy for Athonite monks is among the highest in the world. The incidence of illnesses like heart disease, cancer and Alzheimer’s is practically zero.
What is the human genome sequence useful for ?
Well I have it on my coffee mug.
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  #49  
Old 05-23-18, 07:58 AM
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Re: All disease is preventable

That's being unkind.

There's no requirement for the sequence of the genome - but if it's here and we have lots of them ... ...
help people out in isolated populations who're at risk of monogenic disorders if it's possible. Don't think they'll have any money to pay though ... ... ...

The current biomedical model (involving genetics) is aimed only at rich people in the home of the global reserve currency.

So rich people -> diseases of affluence -> polygenic / complex / multifactorial disease <- environmental change required not genome sequence.

About the best that I can do with the biomedicalgenetic model ... ... ... I'm using imagination now ... ... what would you do with genetics ?

Putting on a genetics hat - and flying the flag for every aspect of genetics - well ... ... ... ... after we've adopted the new psychosocial model of medicine -
- perople are healthy
and we've all of the systems we have currently to analyse DNA ... ... ...

This is REALLY hard.

If anybody has any idea what we're going to do with all of the sequence ?

Well - what do people want to do ?
In the new model - be happy - and learn/develop/express themselves creatively

- so back to the abstraction layer idea - ie we're not meant to be fiddling with previous abstraction layers but fixing our current abstraction layer - which is learning to be better
- in this new world - what use is the sequence of the genome ?

I think that perhaps it might be nice to re-task the powerful server rooms that genomics requires - to power the evolution of device from local CPU to cloud processor ?

That's not a use for the genome ? I know.

You're just suggesting something like - we we could put homeless people into the buildings that we've constructed.
I know.

What is the question ?
From the emergence of mind - there ahs only been ONE question.

How can I (we) be happy ?
And the answer is revealed by simple summary of ALL available information into an answer.

And the answer is 42 ?
No - it's that the human mind is unlocked only when people realise that the point of the human mind is to acquire morality.

Once this happens - developing morality in an environment of collective wisdom - opens the door of the human mind - to the eyes to see a personally motivating path in which personal betterment occurs and reward reinforces naturally.

And that's all there is to it folks.

A world without money in which happy survival is permitted as a birthright to all citizens through collective operation.
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  #50  
Old 05-23-18, 11:14 AM
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Re: All disease is preventable

What is the question ?
Well here - we want to know how to make ADHD work ? Solution provided
I think we'd probably want to know how to be healthy ? Solution provided
And how to be happy ? Solution provided

There is only one intervention required.

A model of education in which the individual acquires morality in a global environment of morality.

One intervention.

This world arises (species-wide enlightenment) from what I've been taught on THIS site by Stabile (Stephen Hawkings) - which is the mechanism of God - provided in the Theory of Everything which is simply the generation of any given evolutionary abstraction layer from 3 dual and one nonpolar interaction.

Imagine [individual in red is the same person]
son -> mother -- WEAK FORCE
husband -> wife -- ELECTROMAGNETIC
husband -> daughter -- STRONG FORCE
man -> others ('love thy neighbour') --> GRAVITY
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  #51  
Old 05-23-18, 11:14 AM
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Re: All disease is preventable

Quote:
Originally Posted by SB_UK View Post
People most generally would stop at common complex (diabetes, obesity, cancer ... ...)
- the rest are quite easy to connect up to -

- but it's much more fun to enter the difficult area of mental disease - but Lunacie, Barliman with his new name, Peripheral and his new name - have nailed it all.

In simple terms (summarising the three presentations of L, B, P) - please don't ask me to find the posts.

not insensitive but overly sensitive -> stress response

The mechanism is described in the Markram and Markram model of 'Intense World Theory' - Markram/Markram like Doll/Peto are the heavy hitters of connectomics.
Quote:
Originally Posted by SB_UK View Post
Now style -

Peripheral - style of Endocrinologist
Lunacie - style of a scientist in pharmaceutical corporation
Barliman - style of an exceptional Professor of Medicine
Fraser - style of an immunologist
Greyhound - style of a zoologist
Tudorose - I think that you do it 'all' :-) at least until it becomes dull
Namazu - definitely an epidemiologist
MeADD823 - style of infectious disease specialist
Sarahsweets - mathematics or dermatology
Ginniebean - style of practicing medic
Sarek - definitely an epidemiologist
Pooka - bioinformatics

I think. Trying to work out where your comments come from.


People don't usually care about the 'molecular mechanism of disease' as we were once called before we were stripped of our Wellcome.
I find it so frustrating to have to read several of your posts to figure out what
point you're trying to make.

Not sure I have it yet. Why do you relate my posts to pharmaceutical science?

You might be surprised at how much of my personal treatment plan includes
natural supplements. At this point I only take one pharmaceutical to manage
my blood pressure, and an antihistamine for allergies.

Certainly I could do more with diet and exercise to manage my health better,
but exercise in particular has been difficult. I have finally found a doctor (PA)
who is helping me to manage my degenerative disk disease after 40 years of
it being completely ignored by a handful of doctors and at least 3 chiropractors.
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  #52  
Old 05-23-18, 12:08 PM
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Re: All disease is preventable

Quote:
Originally Posted by Lunacie View Post
I find it so frustrating to have to read several of your posts to figure out what
point you're trying to make.

Not sure I have it yet. Why do you relate my posts to pharmaceutical science?

You might be surprised at how much of my personal treatment plan includes
natural supplements. At this point I only take one pharmaceutical to manage
my blood pressure, and an antihistamine for allergies.

Certainly I could do more with diet and exercise to manage my health better,
but exercise in particular has been difficult. I have finally found a doctor (PA)
who is helping me to manage my degenerative disk disease after 40 years of
it being completely ignored by a handful of doctors and at least 3 chiropractors.
Without thinking

blood pressure - caused by standard 'stress' -> distress (fight / flight)
Of course being relaxed reduces blood pressure

allergies - eustress
Quote:
Originally Posted by personal experience
The results of the present study demonstrates that fasting suppress hypersensitivity reaction
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190937/
Trust me on this one - I can wipe out all allergies as long as I'm in a place without distress. Currently practicing a 22 hour daily (every day) fast [incorporating MCT oil in the period].

degenerative disk disease - distress - but a diffferent form of distress to above.
high impact (contact/competitive) sports - also see consequences of sports (boxing, football, American football and rugby) and dementia.

eg https://www.theguardian.com/sport/20...amage-dementia

So - the model I've described eliminates all 3.

Thanks - had to think about ddd.
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  #53  
Old 05-23-18, 12:25 PM
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Re: All disease is preventable

Thing about allergy is that there are a huge number of competing environmental cures - so there's a connection to anxiety (both prevented by environmental change), there's a connection to gut biome (prevented by environmental change), by lifestyle ie hygiene hypothesis (prevented by environmental change) ... ... ... so lots of changes which'll help - can't though uniquely identify which one.

Have noticed that there's a very strong relationship (and incredible prevalence) in anxiety&allergy in 3 or 4 sets of cohorts of 150 kids drawn globally (from wealthy families). One striking association which maybe others wouldn't pick up - who studies the kids of parents able to find $75k per year to send their kids to private school ?
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  #54  
Old 05-23-18, 12:27 PM
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Re: All disease is preventable

Not entirely happy with the ddd solution - it'll work - and I'm suggesting that all damaging physical labour / contact sport arise from the competitive instinct which dies off in a moral individual to the backdrop of a moral (globally) society ... ... ... so it works ... ... but would much prefer some lovely epidemiology to help me out... ...
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  #55  
Old 05-23-18, 12:33 PM
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Re: All disease is preventable

Quote:
Originally Posted by SB_UK View Post
Without thinking

blood pressure - caused by standard 'stress' -> distress (fight / flight)
Of course being relaxed reduces blood pressure

allergies - eustress

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4190937/
Trust me on this one - I can wipe out all allergies as long as I'm in a place without distress. Currently practicing a 22 hour daily (every day) fast [incorporating MCT oil in the period].

degenerative disk disease - distress - but a diffferent form of distress to above.
high impact (contact/competitive) sports - also see consequences of sports (boxing, football, American football and rugby) and dementia.

eg https://www.theguardian.com/sport/20...amage-dementia

So - the model I've described eliminates all 3.

Thanks - had to think about ddd.
Okay, stress may play into hypertension.

I have an anxiety disorder, lots of stress.

I think I've always been a pretty moral person so I don't see how that ties in?

I have adhd and autism and sensory disorder, including proproception which
means I've been clumsy all my life. Often tripped over my own feet, small but
possibly cumulative damage.

The injury that started the disk degeneration happened in a fall off a horse.
You know who else rides horses? Buddhist monks. They also do some serious
sports like wrestling as a physical activity, just as important as meditation.
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  #56  
Old 05-23-18, 12:35 PM
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Re: All disease is preventable

Right now things're getting silly.
Quote:
Cell autophagy is extensive participation in the degeneration of lumbar intervertebral disc, delaying the occurrence of degenerative disease.
and you don't even need to scroll down pubmed.

Zhongguo Gu Shang. 2018 Apr 25;31(4)
[Significance of cell autophagy in resorption of lumbar disc herniation].
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  #57  
Old 05-23-18, 12:37 PM
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Re: All disease is preventable

Quote:
The results of the present study demonstrates that fasting suppress hypersensitivity reaction
==
Quote:
Cell autophagy is extensive participation in the degeneration of lumbar intervertebral disc, delaying the occurrence of degenerative disease.
Who'd have thought it ?

Ooooo naughty!!

I get hypotension when I fast - postural hypotension.

:-)

Very naughty.
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  #58  
Old 05-23-18, 12:40 PM
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Re: All disease is preventable

Quote:
Systolic blood pressure (BP) was reduced from 158 +/- 3 mmHg to 146 +/- 5 mmHg (p less than 0.001) and diastolic BP from 96 +/- 3 mmHg to 89 +/- 3 mmHg (p less than 0.01) during the fast.
https://www.ncbi.nlm.nih.gov/pubmed/3389203

Does the reduction remain ?
Of course it does - but one should really do the expt.
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  #59  
Old 05-23-18, 01:01 PM
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Re: All disease is preventable

Quote:
Originally Posted by SB_UK View Post
Right now things're getting silly.


and you don't even need to scroll down pubmed.

Zhongguo Gu Shang. 2018 Apr 25;31(4)
[Significance of cell autophagy in resorption of lumbar disc herniation].
I have never heard of cell autophagy.

Does that make me silly?

Perhaps you could explain or share a link that explains what it is
and how you think it's relevant to my comment.
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  #60  
Old 05-23-18, 02:22 PM
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Re: All disease is preventable

Quote:
Originally Posted by Lunacie View Post
I have never heard of cell autophagy.

Does that make me silly?

Perhaps you could explain or share a link that explains what it is
and how you think it's relevant to my comment.
If something we wear is worn out (imagine the zip failing on your trousers as they ALWAYS do) then we throw the item away into a recycling bin.

Now what would happen if we were forced to wear them as they slowly faded away ? It'd be a little embarrassing.

When all of that happens on the inside - embarrassing means loss of control - loss of cellular control - only two tiny little mutations are required for the genome to lose control.

We know the importance of cleaning our house - but have neglected the cleaning rota on the actual house that we live in.

The human body.
Quote:

When scientists engineer rats that are incapable of autophagy, they’re fatter, sleepier, and have higher cholesterol and impaired brains.
https://greatist.com/live/autophagy-fasting-exercise

I wonder why those ever so clever scientists don't find a buncha' human beings that don't stop eating to show that they're fatter, sleepier, and have higher cholesterol and impaired brains.

What did the little squeaky mouse ever do to deserve to live a life of the average American ?
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