ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community  

Go Back   ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community > SCIENTIFIC DISCUSSIONS, RESEARCH, NEWS AND EVENTS > Scientific, Philosophical & Theoretical Discussions > Open Science & Philosophical Discussion
Register Blogs FAQ Chat Members List Calendar Donate Gallery Arcade Mark Forums Read

Open Science & Philosophical Discussion This forum is for open discussion, encouraging new and unconventional ways of thinking, welcoming posts in any format

Reply
 
Thread Tools Display Modes
  #106  
Old 05-29-18, 03:02 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

What would happen if we artificially ramp up PNS with an electronic device ?
It's the essential same as ramping up PNS any other way ie will lead to resistance via homeostasis.

People will increase dosage and will find themselves generating tolerance to any means of eliciting neural or hormonal activity.

There is only one law of medicine.

Health is generated through asceticism - withdraw ligand - increase sensitivity.

Who'd be neural / endocrine sensitive in this crazy world of nonsense ?
It helps to be a psychopath with desire for money/power so no pain is felt.

So ... ... ... sensitivity (neural endocrine biochemical) has always been the point - but through ramping up the system cf glutamate as major nt of brain -> casein/gluten/meat/MSG/parmesan --> we fix ourselves in a heightened state of arousal - and predispose ourselves to inflammation - the basis to ALL diseases of Western (now global) living.
Reply With Quote
  #107  
Old 05-29-18, 03:08 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

Quote:
Originally Posted by Kunga Dorji View Post
Really it is much simpler than that- we have clear evidence of sympathetic dominance in ADHD, and we also clearly know that high SNS tone drives (through the locus coeruleus) enhanced vigilance and awareness of threat.

The mechanisms causing that high SNS tone are more complex, but they are variants of normal human physiology in a stressed state.

In fact the inattention in ADHD has little to do with an alteration in the "reward system" and much more to do with inreased perceptin of threat coupled with decreased capacity for sensory filtering. Then there is also the issue of inattention caused by orthostatic intolerance (low blood pressure to the brain when sitting up).


Experience orthostatic intolerance when fast and exercise - overcome with water.
Cramping also when water is omitted.
Also carbs increase cramping.
I'm suggesting frequent periods of fasting / ketosis to clean us on the inside.


In the mad rush to work out the mechanism of stem cells - the mechanism was obvious (see Wally Pongo USC fasting for 4 days regenerates immune system) - simply when we eliminate rubbish on the inside by autophagy through fasting - we must replace the cells that have been lost - stem cells were always going to be reactivated through internal housekeeping - we've no choice.
Reply With Quote
  #108  
Old 05-29-18, 03:10 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

Quote:
Originally Posted by Kunga Dorji View Post
In fact the inattention in ADHD has little to do with an alteration in the "reward system" and much more to do with inreased perceptin of threat coupled with decreased capacity for sensory filtering. Then there is also the issue of inattention caused by orthostatic intolerance (low blood pressure to the brain when sitting up).
Exactly

decreased capacity for sensory filtering <- novel informational reward system see Intense World Theory for mechanism of amplifying sensory signal internally - it's very correct
->
increased informational (therefore) immersion
->
(di)stress (same mechanism elicited as actual threat exposure)
Reply With Quote
Sponsored Links
  #109  
Old 05-29-18, 03:16 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

Quote:
Originally Posted by SashaBV View Post
I believe a better system of our species living on planet Earth is not only necessary, but the only way we can survive on Earth as a species. It's necessary to change a lot. But we will never be disease-free. That's physically impossible. We have to control our population, that is a given. We have to clean up the planet and modify our way of living pretty radically. One thing we are dealing with a lot right now is that overpopulation is driving people mad. That and the unbelievable pressure of living under conditions which are increasingly stressful and unhealthy (both physically and mentally), not to mention downright dangerous. Especially in the USA, I believe. Our country, unfortunately, is now an example to the world of what shouldn't ever happen. It could be turned around...but how? And will it happen in time? When is the point of no return as far as the road to extinction? And if we don't change, maybe a planet without any living human beings might be a good thing. Just some thoughts in the night.
Disease-free - use Mount Athos as the model - however noting that they only begin that lifestyle at 30-ish - so we can do MUCH better. Mount Athos has little to no disease. Use them as the starting point - noting that a lifestyle like theirs from grandparent (imprinting) to parents (imprinting/somatic+germline mutation) to uterine environment (imprinting) ie we probably need 3 generations of life within the environment I'm suggesting before the adverse consequences of stress can be seen. Note also - it'll take a few generations to clean the world up of toxins - so there's hope - and it's maybe 3 generations away - though we can reap the rewards immedately.

Sure - for many the damage is already done - but for those who aren't too damaged (retain their teeth from sugar, retain their lungs from smoking etc) ... ... immediate benefits (see Athos) can be reaped immediately.
Reply With Quote
  #110  
Old 05-29-18, 03:21 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

ALL disease is environmental in nature.

That doesn't mean that we won't die - it's just that we'll die without noticing.

Disease can be eradicated by redesigning global society such that all people are free from another person telling (as opposed to explaining nicely) what to do.

This world (in which happy survival essentials are generated by co-operative operation) - is a world in which the individual's reward system changes towards capacity to diving eustress and avoid distress.

It's really as simple as that - we're looking at a novel model of definition of society in which people WANT to do what's best for them.

You can't MAKE people do what's best for them - people have to choose.

There is nothing better than achieving complete mastery over food intake and stopping eating for an extended period - all that's required is warmth and an absence in crazy authoritarians telling other people what to do.

All in this together - what we require is a global co-operative in which the little we need is worked on (all people equally) for themselves.
Reply With Quote
  #111  
Old 05-29-18, 03:25 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

So - this idea (first ten that come to mind) kills off

- the fat cat / slacker
- the common cold
- any form of personal transport in which you're not powering it
- all unsustainable practices
- insensitivity at any level (neural, endocrine, biochemical) in the body
- capitalism
- 'wrong' speech (where one considers only oneself when one talks)
- failed marriages and broken children
- the female being driven through expectation into a life of drink in stress relief
- an absence in information content in words
Reply With Quote
  #112  
Old 05-29-18, 03:26 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

I could list a thousand other positive consequences arising from this idea.

There is no model which can even come close to compete with this model for disease prevention.

There is a pay-per-model which is so embarrassingly simplistic - that I am ashamed to inhabit a world with a species which actually ever thought that it'd work.

Or in plain language.

'Drugs are bad'.
Reply With Quote
  #113  
Old 05-29-18, 10:22 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

Instead of converging - what science appears to have become is a data generating factory where nobody knows what the point is
- and so all people keep their head down - generate data - in the hope that an answer will emerge.
And there we have -omics.

-omics not -ology
- a complete waste of time.

-ologies rationalise to provide the pattern defined in the Theory of Everything.

There is nothing whatsoever wrong with human beings that a mind of MORALITY within context of a species of MORALITY can not cure.

Reality is generated following the autonomous cyclical activity of a structure organising principle to a very defined pattern.
This pattern starts with emergence of male archetype - from which his everted dual appears and then they're away
- progeny
- 24 generations away (this value can be seen eg in the lung - 24 bifurcations to completion) from species generation whereupon the whole thing beginning again
- albeit on the next level.

Physics gives way to Chemistry.
We can tell when a new abstraction layer begins - because a new species forms from a fundamental property.

So Hydrogen gives us the periodic table.

Electron finds proton provides neutron
i (root -1) finds root t provides zero
imaginary + real -> complex ... ... ... the transcendental property which underlies eg chemistry and mathematics here.

The underlying pattern of reality is towards exponential informational increase within the manifest Universe
- by cycles of reducing entropy prior to increasing (novel abstraction layer formation) it again.

Think cyclical sculptures - we're handed some clay and each time around we're required to generate a shape - the shape increases in information content by order of exponential - each time around.

The manifest Universe is programmed to become ever better.

Human beings (prior to a mind) scupper the grand design - but only for the a little evolutionary while
- since formation of mind (individual / collective) was never under any doubt.

The simple observation that the mind was not designed to know stuff but to become morality helps
- as it shows how the mind was supposed to be a compact structure
- data generation explodes the structure
- we're meant to converge not diverge to infinity.

Anyway - with any luck - all is now in place.

The conclusion then - that human beings are and will be fine if one and only one idea is realised.

That the development of morality within a species context defined by morality - opens our eyes to a majestic path in life - one in which our inner cerebellar proxy of quality develops, alongside one other human beings
- into something quite (open your eyes) beautiful.

Collaboration not Competition.
Anybody can try to beat up their fellow man.
But in the process you rescind your evolutionary designation and sink into a Hell of your own making.

There's this choice, see ... ... ...

Last edited by SB_UK; 05-29-18 at 10:33 AM..
Reply With Quote
  #114  
Old 05-29-18, 11:06 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

https://www.ncbi.nlm.nih.gov/pubmed/26696398

Autophagy is required for efficient meiosis progression and proper meiotic chromosome segregation in fission yeast.
->-
recessive developmental disorder genes ONLY 5%
de novo dominant mutations 50%
https://www.biorxiv.org/content/early/2017/11/14/201533

Quote:
For prevention is so so so much better than cure which will never be found.
We're too complex to do anything other than work within the operating instructions of our mechanistic form.

The difference between the rate at which pre-mutagenic damage appears in DNA and the rate at which it is repaired defines the rate at which de novo mutations arise.

So - the pattern observed in cancer can be reflected in the pattern observed in developmental disorders.

Repair mechanisms.

How do we ensure that the repair mechanism has time ?

Note - cells which die upon chemotherapy - fast replication ... ... sperm cell / immune cell / hair follicle

Replication rate.

Increase replication rate -> decrease repair.

Slow down replication rate -by- ... ... ... regenerate immune system by ... .. ....

Everybody hug a Wally Pongo.
https://www.cell.com/cell-metabolism...131(15)00224-7

Fasting / Metabolic ketosis / SCFA through soluble fibre fermentation

4 day fasting cycles [someplace warm and without distress - one needs to concentrate to fast]
Cold pressed omega-3 and MUFA -based oils
Diversity in organic veggies for optimal gut biomic diversity.

-*-

If we can catch 'monogenic' developmental disorders with this idea - which we can - then all of the simple complex, multifactorial, polygenic diseases will fold also.

Diabesity is 100% preventable - nobody disagrees.

But how do we change an individual's food preference ?
Quote:
Originally Posted by In/Flux lyrics
Freedom, that's all that life is [supposed to be]
Simply to realise that we need a global society in which we help one another to be the best that we can be. Only personal excellence can reward.
Beating other people as one's chosen reward system - leaves a deep hole - which grows ever more all consuming as one pursues it as one's chosen path in life.

Collaboration not Competition - if an individual would like a shot at the promised land - it's a place where you're happy without conditionality - a place - where (sensitivity to endogenous narcotic and stimulant pathways)- a place where the endogenous speedball (to die for) - or bliss - becomes one's place to stay.

Last edited by SB_UK; 05-29-18 at 11:26 AM..
Reply With Quote
  #115  
Old 05-29-18, 11:11 PM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

The secret then - would be to work out a mechanism whereby people will elect to a healthy lifestyle.

The rats in rat park elect to a healthy lifestyle when they're in a happy environment.

What does happy environment mean to human beings ?

Quite simply - we need people who display rational morality (this is required to be put in place over the blank slate) - and then for people with developing/developed morality within context of society of developed morality - doing whatever it is that they (as an individual/collective) desire.

I'd suggest complete dismantling of the workplace - it is an embarrassment - a species of people who think that they're doing something worthy - when in actual fact they're simply destroying themselves, others and the planet in their desire for money and power.

And then we need to clean up the planet - move to zero waste - clean up the poop from our countryside so people can walk barefoot in the grass and have all the rest - proper food grown locally, sustainable energy, insulated houses generated sustainably ... ... clean up the planet and ensure that all people have happy survival essentials through contributing time.

And thereafter (the old model of University) move to a centre of excellent and become excellent in whatever you'd like - without ANY expectation of money/power ... ... since you're now in it for your quality self and not for your primitive (eat thy neighbour) self.

-*-

What use is -omics ?
It's nonsense - data generating rubbish.

What use is medicine ?
It's nonsense - downstream pretend repair (only for money) of problems which can be prevented upstream.

What use is bioinformatics ?
See -omics ?

What use are databases filled with vast amounts of data generated by tech on man ?
See -omics and bioinformatics.

What is worthy ?
Anything that an individual could call a hobby - anything that results in a human being becoming better on the compatible - mind, body, spirit levels.

Body - assessed through aerobic fitness, co-ordination, flexibility
Mind - assessed through depth of morality / rationality - once wisdom is gained - one develops motivation, the eyes to see what is needed - and the capacity to use creative insight in development of what is required.
Spirit - autonomy, mastery and purpose - to become better at something worthwhile (requires mind of rational morality before a spiritually uplifting path may be elected)

What is 'spirit' ? In this sense - it's personal betterment through developing personal quality.
So - spirit relates to metalevel (the single unit which makes up reality) and which evolves to generate the constantly changing (evolving) metamodel web.

The spirit wishes to ascend (the metalevel is like a ladder - and can not stabilize - need continue to ascend) ... ... and the 'form' which spiritual ascent takes is in evolutionary consciousness or the development of increasing depth of pattern recognition (personal quality) in man - as the current evolutionary task set to man.

We can not be happy unless we're engaged in a personally satisfying development of personal quality - a general imperative which can be inferred from simple understanding of the nature of manifest reality - how it came to be, and how it will (in time) change.
Reply With Quote
  #116  
Old 05-29-18, 11:25 PM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

Maintain physiology by defining mind [ie of morality] NOT correct pathophysiology.
We're too complicated to correct a broken body with a spare part.


Sure - antibodies seem to be specific - but we're eliminating aspects of the body as a system - we can't delete aspects of a single system without repercussions. Removal of the immune system might seem like a good idea if suffering from self-destruction - but watch what happens when on chemotherapy - the bug then gains the capacity to kill us.
Reply With Quote
  #117  
Old 05-30-18, 12:41 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

Why are human beings behaving like idiots (in data generation) ?

Simply 'molecular' minds - which prevent a System mind from forming.

In the absence of 'the big picture' - human beings generate a potentially infinite amount of data in their chosen speciality and strive towards increasing their money and standing (power).

Once upon a time - there was a realization that science needed to be hypothesis driven.

There is no hypothesis in modern medical research - it's appalling.

As mentioned by Stabile 15 years ago here:
Quote:
Originally Posted by Stabile View Post
Hey, SB:
Here are some quick points from the end of your post:
There’s a desperate sense to the genetic studies I’ve seen. The problem is that the statistical view has a compelling nature, and the dangers aren’t obvious. But the result is bad science, in my not so humble opinion.
What we are increasingly doing, in this modern world of studies that reanalyze and reinterpret data from other studies, is giving up on the scientific idea of actually explaining the mechanisms at work in some process of nature.
There is even an idea being promoted that it is somehow morally incorrect to try to understand such connections when they involve the function of the mind. This by some big guns, too, most notably Noam Chomsky.
Here is our problem with the type of study that you cite: we know that there is an additional level of logic between the context that is directly affected by genetic information and the conscious experiential context in which we identify AD/HD. This additional layer of logic makes the contribution of the genetic material indirect, at best.
Just a series of people with :-) high throughput technologies, massive data generating and data crunching capacity - thing is - is that the human mind is allowed to be thick enough, when it's just out of University to think that the gene will help to explain away disease and will identify the drug which'll help the ill individual - but give it a little time in these areas - and really - one should grow the eyes to see that you're beating your head against a brick wall.

The human mind should not be interested (be incapable of paying attention) to utter garbage.
We're meant to strive towards bettering ourselves - not playing with toys that generate truly massive amounts of data, which require toys to analyze and then toys to show everybody what we've done.

The WHOLE of modern biological/medical research is the equivalent of releasing oneself after holding it in for the best part of a day - and then rushing to encourage all of your fellow co-workers to come and admire your U bend blocking handiwork.
Prolific yes - but really quite repulsive to any movement towards improving individual/collective health.

ALL human problems are overcome through realising that the point of mind is to acquire morality.
Quote:
Originally Posted by Stabile
Enforced moral consistency
The point of mind is to acquire wisdom - not to be a techy boy racer with the capacity to go from 0 - 60 Terabytes of data faster than any other person alive; all that's required here is money - to be able to afford better equipment than others.
What is expressly not required is a human mind - since the human mind rejects any need for technology of any sort in solving ALL of the problems of man.

Last edited by SB_UK; 05-30-18 at 12:52 AM..
Reply With Quote
  #118  
Old 06-22-18, 03:01 AM
Kunga Dorji's Avatar
Kunga Dorji Kunga Dorji is offline
ADDvanced Forum ADDvocate
 

Join Date: Nov 2008
Location: Australia
Posts: 4,620
Blog Entries: 2
Thanks: 1,592
Thanked 6,119 Times in 2,884 Posts
Kunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond repute
Re: All disease is preventable

Quote:
Originally Posted by SB_UK View Post
ALL disease is environmental in nature.

That doesn't mean that we won't die - it's just that we'll die without noticing.
"Monty Python's Meaning of Life.

The "recently deceased in question' (the hostess of a dinner party in which she had unknowingly served rancid salmon mousse was quite put out when she realized what had happened, and tried to have an argument with death.


I sort of think a similar issue came up in Beetlejuice too.


God, I'm old. how do i remember all this?
__________________

Whenever you see a crowd all rushing in the same direction on any one issue, run in the opposite direction.

There is neither fun nor profit to be had in polishing the brass knobs on a bandwagon.
Nicholas Nasseem Taleb.


Reply With Quote
The Following User Says Thank You to Kunga Dorji For This Useful Post:
SB_UK (06-28-18)
  #119  
Old 06-22-18, 09:54 PM
Kunga Dorji's Avatar
Kunga Dorji Kunga Dorji is offline
ADDvanced Forum ADDvocate
 

Join Date: Nov 2008
Location: Australia
Posts: 4,620
Blog Entries: 2
Thanks: 1,592
Thanked 6,119 Times in 2,884 Posts
Kunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond reputeKunga Dorji has a reputation beyond repute
Re: All disease is preventable

Quote:
Originally Posted by SB_UK View Post


ALL human problems are overcome through realising that the point of mind is to acquire morality.


The point of mind is to acquire wisdom - not to be a techy boy racer -----

So- we have 2 separate items each listed as "the point of the mind". Im struggling with understanding what you are saying here. For reference- wisdom and compassion are listed separately in Buddhist writings, and that is the only system simple enough for me to understand.

The next question is "what is this "Morality" that is apparently "out there" and needing to be acquired by us?

I do have a reasonable option for this one, as described by Antonio Damasio (neurologist).
He comments that consciousness can be regarded as a tool that the organism uses to maintain its homeostasis- get the right level of nutrition, water, warmth, etc. Human consciousness includes the capacity to create a story about this activity, one which is compelling enough to improve your motivation. The story requires a subject, a hero, hence the ego is a convenient fiction that helps you organise your life.

The trick here is that there are other egos walking about all competing for resources. So the stories told have become more elaborate, and involve others in such a way that we all get to benefit and stay alive.
__________________

Whenever you see a crowd all rushing in the same direction on any one issue, run in the opposite direction.

There is neither fun nor profit to be had in polishing the brass knobs on a bandwagon.
Nicholas Nasseem Taleb.


Reply With Quote
The Following User Says Thank You to Kunga Dorji For This Useful Post:
SB_UK (06-28-18)
  #120  
Old 06-28-18, 03:07 AM
SB_UK SB_UK is offline
Suspended Account
 

Join Date: Aug 2004
Location: -
Posts: 20,901
Blog Entries: 20
Thanks: 6,147
Thanked 6,454 Times in 4,704 Posts
SB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond reputeSB_UK has a reputation beyond repute
Re: All disease is preventable

Quote:
Originally Posted by Kunga Dorji View Post
So- we have 2 separate items each listed as "the point of the mind". Im struggling with understanding what you are saying here. For reference- wisdom and compassion are listed separately in Buddhist writings, and that is the only system simple enough for me to understand.

The next question is "what is this "Morality" that is apparently "out there" and needing to be acquired by us?

I do have a reasonable option for this one, as described by Antonio Damasio (neurologist).
He comments that consciousness can be regarded as a tool that the organism uses to maintain its homeostasis- get the right level of nutrition, water, warmth, etc. Human consciousness includes the capacity to create a story about this activity, one which is compelling enough to improve your motivation. The story requires a subject, a hero, hence the ego is a convenient fiction that helps you organise your life.

The trick here is that there are other egos walking about all competing for resources. So the stories told have become more elaborate, and involve others in such a way that we all get to benefit and stay alive.
Will be back to reply to both comments soon - 3 job interviews - have to somehow become an expert in the microbiome, cancer and the developmental disorder in 3 days !!
What a nightmare.
Thanks for the comments - just saw your comments on the way to post this --->---


:-)

The basis to asthma/allergy (atopy) (and many other diseases)


So - in one sentence (described below) - we're looking at distress [2] (through inherited sensitivity [1] of the sensory system) driving insensitivity/hypersensitivity at the level of human physiology (the neuroendocrine system) [3,4,5] resulting in loss of general inflammatory control and reactive appetite preference change [6] resulting in a metabolic shift altering the biome (gut then respiratory) which results in the inappropriate specific inflammatory response [11] being elicited [8,10], promoted [7] and not controlled [9].

This model connects all of the major -OMICs and medical disciplines into 1 unifying model.
-OMICs - genomics, epigenomics (transcriptomics), biomics, connectomics
&
-medical specialities - cardiology, endocrinology, gasteroenterology, haematology, infectious diseases, oncology, neurology, pathology, psychiatry, public health, renal, respiratory, rheumatology and urology.

1
Informational sensitivity (inherited condition) and high psychological 'distress'/low psychological 'eustress' (eg poverty, fear of poverty) ie distress NOT eustress in inherited stress sensitivity
->leads to->
2
'Distress' reaction when surrounded by too much information (an alternative basis to the Hygiene Hypothesis since the farm would be a low stimulation/stimulant environment)
->leads to->
3
Neuro (increased SNS activation, decreased PNS activation) Endocrine (increased stress hormone (cortisol) production)
->leads to->
4
Desensitization of SNS agonists (requiring b2AR for treatment), desensitization to glucocorticoid (requiring steroid for treatment) and Sensitization to PNS (explaining our heightened response to eg methacholine)
5
-> ie we generate an imbalanced autonomic nervous system (explaining away eg heat/cold induced asthma which call on the ANS) and a blunted response to cortisol (essential for control of the immune system)
6
-> 'Distress' leads to comfort eating (these foods activate Insulin/IGF-1 eg the takeaway which is generally a combination of starch and protein) and reduces affinity for foods without such an immediate neuroactive effect (ie soluble fibre/anti-oxidants in low GI veggies which do affect mood (95% of serotonin is produced by gut bacteria) but not in such an obvious, immediate fashion)
7
-> Pro-growth foods mixed with pro-inflammatory foods (LPS from bacteria even if killed) results in de novo synthesis of nucleosides giving us the role of theophylline (adenosine antagonist) as a therapeutic in asthma and the reason why caffeine (adenosine antagonist) dramatically increases my speed when running long distances
8
-> So - we shift into a 'growth-promoting' internal environment through shifting from veggies (gut butyrate / liver b-hydroxybutyrate) production into consuming growth-promoting/pro-inflammatory agents.
9
-> The consequence of shifting from salvage (recycling/renewal) into de novo synthesis (ie as a consequence of metabolic shift from ketosis-type into blood glucose fluctuation-type ie as a consequence of reactive appetite preference change to distress in a sensitive (CNS) individual) is that we lose access to the autophagy/apoptosis response (recycling/renewal) which in effect means that we can not deselect self-reactive (or inocuous allergen reactive) immunological cells of the specific immune system
10
-> The gut biome changes (through appetite change) and in line with the loss of control of the immune system (incapacity to access immune tolerance through metabolic shift) and priming of the immune system (through Insulin/IGF-1 promotin diet), we launch inappropriate immune reactions (involving reactive oxygen species) which manifest at the gut (opening up the gap junctions at the gut) and which lead to the shift from ROS sensitive to ROS resistant (the troublesome gammaproteobacteria) bacteria which subsequently translocate into other 'similar' areas of the body (the respiratory biome) where they drive inflammation (similarly to the gut) in their new resting place
11
-> This gives us the pattern of increased NO in exhaled air as a component of the inflammatory response in asthmatic, as NO and ROS combine to attack perceived threat.

So - in one sentence (described above) - we're looking at distress [2] (through inherited sensitivity [1] of the sensory system) driving insensitivity/hypersensitivity at the level of human physiology (the neuroendocrine system) [3,4,5] resulting in loss of general inflammatory control and reactive appetite preference change [6] resulting in a metabolic shift altering the biome (gut then respiratory) which results in the inappropriate specific inflammatory response [11] being elicited [8,10], promoted [7] and not controlled [9].

This model connects all of the major -OMICs and medical disciplines into 1 unifying model.
-OMICs - genomics, epigenomics (transcriptomics), biomics, connectomics
&
-medical specialities - cardiology, endocrinology, gasteroenterology, haematology, infectious diseases, oncology, neurology, pathology, psychiatry, public health, renal, respiratory, rheumatology and urology.
Reply With Quote
Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Collecting Scientific Data - ? Usefullness SB_UK Open Science & Philosophical Discussion 35 04-04-13 03:21 AM
Definition of Disease Hyperman87 General ADD Talk 1 12-15-11 07:07 PM
The Midnight Disease... JT95 General ADD Talk 16 11-16-04 12:17 PM
Bipolar Disorder a Misunderstood Disease Andi Bipolar 0 09-25-04 12:56 PM


All times are GMT -4. The time now is 11:40 AM.


Powered by vBulletin® Version 3.7.4
Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
(c) 2003 - 2015 ADD Forums