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Old 10-09-18, 11:26 AM
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ADHD boost Parkinson's risk

Not trying to scare anyone but ADHD & Parkinson's disease share a link.Apparently both of these illnesses effect the dopamine pathways in the central nervous system. Parkinson's disease starts 20-50 years after the initial ADHD diagnosis in those who develop both diseases. I knew it, I just hate being right about this.As I have Parkinson's myself!

https://www.webmd.com/add-adhd/news/...y-parkinsons#1

https://www.healthline.com/health-ne...dication-story
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Old 10-09-18, 02:21 PM
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Re: ADHD boost Parkinson's risk

Quote:
What's more, among "those ADHD patients who had a record of being treated with amphetamine-like drugs -- especially Ritalin [methylphenidate] -- the risk dramatically increased, to between eight- to nine-fold," said senior study author Glen Hanson.
I do not like this at all. I want to see the study and see if its peer reviewed. I want to see if the scientific community supports this or if its one person. I would want to see their study participant samples and if there is an appropriate control group.
Are they saying amphetamines are ok and only amphetamine like drugs are bad? Or do they mean amphetamines as well?
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Old 10-09-18, 10:00 PM
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Re: ADHD boost Parkinson's risk

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Originally Posted by sarahsweets View Post
I do not like this at all. I want to see the study and see if its peer reviewed. I want to see if the scientific community supports this or if its one person. I would want to see their study participant samples and if there is an appropriate control group.
Are they saying amphetamines are ok and only amphetamine like drugs are bad? Or do they mean amphetamines as well?
Any possible link between ADHD patients and use of psychostimulant medications with Parkinson’s disease is “not causation… We don’t know that the relationship we observed is caused by the [ADHD] treatment,” Curtin said. “It would take further study.”

“It could be the people that end up being prescribed for ADHD, their condition is just more severe, and it’s the more severe ADHD itself that is predisposing the brain to Parkinson’s-like disorders,” said Curtin. “I don’t want to, at this point, blame the medication [for the development of Parkinson’s].”


No genetic association between attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease in nine ADHD candidate SNPs.
Geissler JM1; International Parkinson Disease Genomics Consortium members, Romanos M2, Gerlach M2, Berg D3,4,5, Schulte C3,4.
Collaborators (127)


Author information


Abstract
Attention-deficit/hyperactivity disorder (ADHD) and Parkinson's disease (PD) involve pathological changes in brain structures such as the basal ganglia, which are essential for the control of motor and cognitive behavior and impulsivity. The cause of ADHD and PD remains unknown, but there is increasing evidence that both seem to result from a complicated interplay of genetic and environmental factors affecting numerous cellular processes and brain regions. To explore the possibility of common genetic pathways within the respective pathophysiologies, nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls: one variant, respectively, in the genes coding for synaptosomal-associated protein 25 k (SNAP25), the dopamine (DA) transporter (SLC6A3; DAT1), DA receptor D4 (DRD4), serotonin receptor 1B (HTR1B), tryptophan hydroxylase 2 (TPH2), the norepinephrine transporter SLC6A2 and three SNPs in cadherin 13 (CDH13). Information was extracted from a recent meta-analysis of five genome-wide association studies, in which 7,689,524 SNPs in European samples were successfully imputed. No significant association was observed after correction for multiple testing. Therefore, it is reasonable to conclude that candidate variants implicated in the pathogenesis of ADHD do not play a substantial role in PD.
KEYWORDS:
ADHD; CDH13; Dopamine transporter; GWAS; Parkinson’s disease; SNPs



oher info

their is a known genetic condition with a psychiatric phenotype with about 95% presenting with adhd


the same genotype also is known to cause a Parkinson like tremor ataxia In the peoples 50s and 60s
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Old 10-10-18, 02:52 PM
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Re: ADHD boost Parkinson's risk

Well, there's also a "risk" of having both ADHD and ASD ...
or both ADHD and Bipolar.

I would call it a "link" instead of a "risk" at this point.
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Old 10-10-18, 03:07 PM
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Re: ADHD boost Parkinson's risk

Considering they're already starting to do studies on the MTHFR gene mutation and it's correlation with both ADHD and Parkinson's, along with lots of other ailments, illnesses, and conditions... Unfortunately I don't find this that surprising.
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Old 10-13-18, 02:40 PM
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Re: ADHD boost Parkinson's risk

Yeah I just figure I'd throw this out there.In some of the articles the meds for ADHD are blamed as a potential cause(I don't like that one bit,as I think ADHD itself is a cause.) Ritalin is sometimes used to treat Parkinson's disease https://www.michaeljfox.org/foundati...p?grant_id=344

But anyway it is interesting. Not everyone with ADHD needs to worry about this, only those of us who go on to develop Parkinson's like symptoms.
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