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  #1  
Old 09-17-19, 04:10 PM
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Duloxetine+methylphenidate (Never try!)

This is a past event but it's very important i think. I couldn't find time or maybe forget to write here until now.
My doctor had prescribed me duloxetine 30 mg+concerta 54 mg about one month ago. At first day I took dulox at morning it made me only mildly tachycardic and about 2 hour later i took ritalin 5 mg (doctor had prescribed concerta but i took ritalin consciously because both dulox and mph increase noradrenaline and i hesitated to take concerta).20 minutes later after i took ritalin i became extremely tachycardic and hypertensive. I had never felt so before. I drove to hospital to be near medical aid. I was undecided so i waited in car in garden of hospital. My heart beats returned to normal after about half an hour.

I couldn't find much information about this combination.
Did anyone of you took these together?
Could this combo be used?
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Born in 1989. Treated for major depression and anxiety since 21 yo.
Tried almost all of SSRI's (none of them worked)
Predominantly inattentive adhd, diagnosed in 2018.
Started with ritalin (worked only for two weeks)
Also tried wellbutrin and strattera
Now: ritalin and medikinet
For about three years local corticosteroid pomades for atopic dermatitis.
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  #2  
Old 09-17-19, 06:08 PM
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Re: Duloxetine+methylphenidate (Never try!)

Drugs dot com does list Cymbalta (duloxetine) and Ritalin, as well as Concerta,
as being contra-indicated because of nervous system side effects.

Since both Ritalin and Concerta are forms of MHP (methylphenidate) it's a bit
surprising that the doc prescribed them both together. Especially if 54 mg of
Concerta was the starting dose. The usual Concerta starting dose is 36 mg.
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Old 09-17-19, 11:52 PM
PI-ADHD 29 PI-ADHD 29 is online now
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Re: Duloxetine+methylphenidate (Never try!)

Quote:
Originally Posted by Lunacie View Post
Drugs dot com does list Cymbalta (duloxetine) and Ritalin, as well as Concerta,
as being contra-indicated because of nervous system side effects.

Since both Ritalin and Concerta are forms of MHP (methylphenidate) it's a bit
surprising that the doc prescribed them both together. Especially if 54 mg of
Concerta was the starting dose. The usual Concerta starting dose is 36 mg.
I have already been taking concerta 54 mg almost for one year. It's not starting dose. Doctor added duloxetine subsequently.
I talked doctor about that and asked him if these are contra-indicated. He said maybe. He said every drug may work in different ways for each of people, two plus two isn't four every time in medicine.
I'm ok with my doc in general but sometimes i lost my reliance, confidence on doctors. Maybe i would have died if i had used drugs how they were prescribed.
__________________
Born in 1989. Treated for major depression and anxiety since 21 yo.
Tried almost all of SSRI's (none of them worked)
Predominantly inattentive adhd, diagnosed in 2018.
Started with ritalin (worked only for two weeks)
Also tried wellbutrin and strattera
Now: ritalin and medikinet
For about three years local corticosteroid pomades for atopic dermatitis.
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Old 09-18-19, 01:03 AM
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Re: Duloxetine+methylphenidate (Never try!)

Quote:
Originally Posted by Lunacie View Post
Drugs dot com does list Cymbalta (duloxetine) and Ritalin, as well as Concerta,
as being contra-indicated because of nervous system side effects.

Since both Ritalin and Concerta are forms of MHP (methylphenidate) it's a bit
surprising that the doc prescribed them both together. Especially if 54 mg of
Concerta was the starting dose. The usual Concerta starting dose is 36 mg.
Lunacie, I have make the same search in drugs dot com and there is no interaction:

https://www.drugs.com/drug-interacti...-1606-979.html

But every person is a different case and responds different to the medications . Greetings.
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Old 09-18-19, 05:35 AM
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Re: Duloxetine+methylphenidate (Never try!)

An interesting study:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910994/
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Old 09-18-19, 12:30 PM
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Re: Duloxetine+methylphenidate (Never try!)

Quote:
Originally Posted by benito View Post
Lunacie, I have make the same search in drugs dot com and there is no interaction:

https://www.drugs.com/drug-interacti...-1606-979.html

But every person is a different case and responds different to the medications . Greetings.
Scroll down on that page just a little ways, under drug and food interactions:

Moderate risk ... if taking both drugs and then drinking any alcohol.


Not a problem if you're not a drinker. I very rarely drink any alcohol,
maybe twice a year I'll have a Margarita if dining in a Mexican restaurant.
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Old 09-18-19, 12:34 PM
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Re: Duloxetine+methylphenidate (Never try!)

Quote:
Originally Posted by benito View Post
Interesting. My doc switched me from Zoloft to Cymbalta early this year.
Meanwhile I've halved my daily dose of Omega 3 fish oil, which I take for adhd,
because it's a blood thinner and I've been getting a lot of purpura on my arms.
Those are blood bruises under the skin.

I was a bit worried that my adhd symptoms would worsen due to the decrease
in Omega 3, but perhaps the Cymbalta (duloxetine) is making up the difference.
__________________
ADD is not a problem of knowing what to do; it is a problem of doing what you know.
-RUSSELL A. BARKLEY, PH.D.


As far as I know, there is nothing positive about ADHD that people can't have w out ADHD. ~ ADD me
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Old 09-18-19, 12:49 PM
PI-ADHD 29 PI-ADHD 29 is online now
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Re: Duloxetine+methylphenidate (Never try!)

Quote:
Originally Posted by Lunacie View Post
Interesting. My doc switched me from Zoloft to Cymbalta early this year.
Meanwhile I've halved my daily dose of Omega 3 fish oil, which I take for adhd,
because it's a blood thinner and I've been getting a lot of purpura on my arms.
Those are blood bruises under the skin.

I was a bit worried that my adhd symptoms would worsen due to the decrease
in Omega 3, but perhaps the Cymbalta (duloxetine) is making up the difference.
Do you take any med (especially stimulants) with cymbalta? And what's your cymbalta dose?
__________________
Born in 1989. Treated for major depression and anxiety since 21 yo.
Tried almost all of SSRI's (none of them worked)
Predominantly inattentive adhd, diagnosed in 2018.
Started with ritalin (worked only for two weeks)
Also tried wellbutrin and strattera
Now: ritalin and medikinet
For about three years local corticosteroid pomades for atopic dermatitis.
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  #9  
Old 09-18-19, 02:44 PM
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Lunacie Lunacie is offline
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Re: Duloxetine+methylphenidate (Never try!)

Quote:
Originally Posted by PI-ADHD 29 View Post
Do you take any med (especially stimulants) with cymbalta? And what's your cymbalta dose?
No stimulants. I was lucky enough to stumble into Omega 3 fish oil at the same
time I started learning about ADHD and realized that's a big part of my life.

I take 20 mg of Cymbalta twice a day.
__________________
ADD is not a problem of knowing what to do; it is a problem of doing what you know.
-RUSSELL A. BARKLEY, PH.D.


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