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Old 03-11-10, 09:32 PM
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Exclamation Experienced symptoms of Parkinson's Disease after taking Adderall for a few months

First off, hello to everyone. I've been a lurker here for almost half a year, a feat of some considerable magnitude given my general verbosity and inability to contain said verbosity. No one here knows what that's like though, right?

I wanted to hear from my need-for-stimulation brothers and sisters on the matter of an extremely worrisome side effect I had that resulted in my discontinuation of Adderall.

Several months ago my doctor diagnosed me as having ADD. I'm a thirty-three year old man, so it took a long time to come around to that diagnosis. He wasn't the first doctor I've seen in my quest to find an answer ... as a matter of fact, he's probably about the tenth doctor I've seen in the last decade, and the only one that's been worth a damn. (He isn't an ADHD specialist, though).

Said doctor prescribed Adderall IR for me, ramping me up to 15mg twice a day after a few weeks. Everything seemed great at first (not euphoric). I'd never known that it was possible to sit and not think. Never, ever had I had a waking moment that wasn't filled with a running internal monologue, thoughts that jump from wondering about nuclear physics one second to wondering what kind of lacy things the pretty girl that just walked by was wearing to ... hey look, a squirrel!

After a few weeks, it didn't seem to be working so well. It seemed my "baseline" was gradually going down week after week even though I started taking at least one day off of it every weekend.

I started experiencing muscle pain after a while. I'm not really sure when. Pain has been a part of my life for a while, so I don't even really notice it much. Besides, I've read plenty of complaints about muscle pain here, so I just ignored it and popped a few ibuprofen now and then. After a while I started to notice a tremor in my hands, and then my movements started to slow down. I was getting cranky and irritable regardless of where I was in my daily medicine routine.

After about two months on Adderall, the tremor in my hands was accompanied by a slight side-to-side tremor for my head. Right about then, that's when my vision started to get blurry.

The blurry vision marked the beginning of the end for Adderall for me. Over the next five days I kept taking my medicine as prescribed. I became even more irritable and cranky. I was becoming even more forgetful than I normally am. My movements became labored. All my muscles started becoming rigid, and I even began walking stooped over with a shuffling gait. I went to see an opera with my wife one of those evenings, and I was being passed walking up the stairs by elderly people walking with canes.

Obviously I was becoming extremely concerned by this point (in my lucid moments). I skipped my morning dose the day after the opera. I could barely work as I was having trouble holding my tools. I took my afternoon dose and the symptoms got worse. I realized I'd just made a mistake by taking that dose. I called my doctor immediately, and he seemed alarmed and instructed me to stop taking the Adderall for a few days, then try it for a few days at a reduced dosage. That couldn't help for the dose I had just taken, and I was thankfully able to get home that afternoon before I locked up and couldn't move anymore.

The next morning I was able to move, but only barely. I took the day off from work, but it took around two days for me to get to a point where I felt like I could control my muscles. I took several days off the meds, and I resumed them at half the original prescribed dosage (7.5mg twice daily). After several days, the Parkinson's like symptoms returned, and thus ended my experiment with Adderall.

I did a search on the forums using Google (the site's search engine isn't working for me at the moment); anything I found regarding Parkinsonism was mostly speculation about long term effects of amphetamine medication, not a concurrent side effect of Adderall usage, and I just gave up after a point. Google searches haven't really helped me determine if this is a rare side effect of Adderall usage, either. Apparently methamphetamine users can experience Parkinsonism, but obviously a drug addict would be taking significantly higher doses (yes, I know they're not the same drugs).

The disconcerting part of this, though, is that I stopped taking Adderall about four weeks ago, but I find that I am gradually getting weaker and my hand tremor is returning. This afternoon I had to use my shopping cart to hold myself up when I was at the grocery store, and I was so weak by the time I put my scant few items on the check-out conveyor that I had to have a store employee push my cart out to my work truck for me. I left everything that wasn't cold or frozen in the truck when I got home. Last summer I was lifting 100lbs compressors onto rooftops with a rope, but this afternoon I could barely manage the dexterity in my hands to bring in two six packs and a half gallon of ice cream.

I would like to know if any of you have experienced any Parkinsonism symptoms whilst taking any of the stimulant meds. Alternatively, does anyone know of a similar story to mine? It bothers me to even think of the possibility that I could have Young Onset Parkinson's, though it would make my nickname (and ADDForum user name) somewhat ironic.

(Yes, I have an appointment to see my doctor soon, so please spare me the usual "see your doctor" forum spam.)
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Old 03-12-10, 01:00 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

See your doctor.

(sorry, couldn't resist). Telling me not to do something is usually a great way to get me to do that thing in question.

That sounds scary, I've only been taking Adderall for 2.5 weeks (now on 15 mg IR 3x a day as needed) and I haven't noticed any of those symptoms, nor euphoria. Just as you said, that my brain can actually shut up for a little while.

I have no idea what to say and I'm not a doctor so this is not medical advice, but it seems to me if the symptoms are coming back off Adderall, perhaps it is some other medical issue. Maybe one of your vitamin or nutrient levels is low.... again, I have no idea what I'm talking about as I'm not a doctor, so the best solution is to 'see your doctor.'

(sorry couldn't resist doing it twice).
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Old 03-12-10, 03:08 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

I am not a doctor. I don't play one on TV.

I had to quit Adderall IR at 40 mg/day very suddenly due to my partner having significant health issues. I experienced a great deal of what you are going through.

Two things call out- you experienced a strong sensitivity fairly quickly and you discontinued the med quickly.

Some things that helped me-

OJ every morning. Seriously. 6 oz minimum when I woke up and might have more through the day. Add to that, one litre of water every day at a minimum. Should be two. And B Complex.

You should also add exercise as you are capable of.

Hope some of this helps.
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Old 03-12-10, 03:36 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

Mr. Fox,

Some of those side effects seem kind of scary. I've never heard of Adderall doing that to anyone before.

This is just a stab in the dark, but you might want to ask your doc about trying out tyrosine to augment your Adderall. Tyrosine is a chemical precursor to L-DOPA, a common anti-Parkinson's agent, so it might help with these side effects. Plus, if you co-supplement with tyrosine, you can sometimes get by with a lower medication dosage.

Again, this may not be the best advice, but maybe worth looking into?
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Old 03-12-10, 04:35 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

I am going to add this before moving the thread to the adderall section as this is a medication question -

Can one get tremors from ADD medications - yes it is not typical but it is not impossible either A small sub-set of folks seem to be prone to getting "tics" and tremors due to stimulants - this is more common with ritalin than adderall but it can happen with either

If I remember my basic biology correctly ADD medications effect our dopamine levels - dopamine is also necessary for voluntary muscle movement I remember my Parkinson's 101 correctly the tremors in Parkinson are also dopamine related - it may be that your body is simply unable to produce enough dopamine to have re uptake inhibited by the ADD medications and also cover the amount necessary for proper muscle movement but this should resolve shortly after the ADD medications are stopped

Now the tremors should be decreasing or stopping when you quit the ADD medications - if they don't you need to pursue the cause like a hound on a hunt -


I have heard of one case of another member here who took adderall XR very successfully for a short time and began having similar symptoms as those you describe but when he stopped the medications the tremors did NOT go away they got better for a short while and then returned even in the absence of medications. . I am not saying this is the case but the poor man went though a lot before getting a brain scan which did reveal the problem Long story short the meds simply made an unknown secondary condition more noticeable and no it was not Parkinson


I have Parkinson in my family yet I am on 80 mg of adderall IR daily and have been for years so far I have not had any problems with tremors -
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Old 03-12-10, 11:14 PM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

@Kalimba- Not trying to scare anyone off their meds, amigo. Just trying to find out if I have another condition that it might have unmasked.

@meadd823- This is the kind of response I was looking for. From my basic understanding of neurotransmitters and my observations over the last few months, it seemed reasonable to me to draw the same conclusion about my brain not producing enough dopamine for the Adderall to work with. I'm concerned that there's another underlying medical condition at work here. I'd greatly appreciate it if you had any more insight about the user you mentioned.
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Old 03-13-10, 12:16 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

How weird.

Your experience is exactly the opposite of what one would intuitively expect. Parkinson's is characterized by a lack of dopamine and ADD (at least as I understand it) is characterized by a lack of dopamine receptors. Adderall stimulates dopamine production and therefore, because more is produced, there is more to be picked up by the receptors we do have.

I looked up the symptoms of too much dopamine and what I found talked about mental symptoms like psychosis.

Just out of curiousity, how well were you sleeping when you were taking the Adderall? How much did you sleep, and when you woke up, did you feel like it was a restful sleep? Did you dream?
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Old 03-13-10, 11:02 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

Parkinson's is a result of your brain cells self deteriorating and producing less and less dopamine


you are experiencing adderall with drawl. you cells produce less dopamine cause it got used to adderall and your body is always self adjusting. so with time you should go back to normal before adderall. balance again.


I dont think your symptoms will worsen with time, they would go away.


parkinson is when you symptoms worsen with time.

namenda parkinson medication is currently being studied for adhd treatment and meth addiction. It can be used to reverse adderall tolerance because its suppose to rejuvenate or reactivate your brain cells.
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Old 03-13-10, 01:17 PM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

Adderall increases production of dopamine
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Old 03-13-10, 02:20 PM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

I'll update this thread after I see my doctor on Tuesday, but after receiving a few private messages I was able to put a few of the puzzle pieces together and find an entirely new suspect that I normally would have never considered: late stage Lyme disease. It (specifically Lyme encephalopathy) accounts for every diagnosis that every doctor has made for me over the last few years (ADHD, bipolar, panic disorder, et al.) and also includes the neurological symptoms that I've been ignoring (pins and needles in my extremities, arthritic knees for years, the lesions on the back of my hands, my deteriorating short term memory, my deteriorating short term memory ... oh wait). I spent a lot of summers on my uncle's ranch when I was a kid, and I pulled a lot of ticks off me during those summers, so it's a good thing to rule out. Very interested to see what my doc thinks.
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Old 03-13-10, 02:34 PM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

Sorry being more specific now that I have fewer cats crawling about my key board - can of cat food works wonders for the focusing ablity where adderall may fail

Okay adderall increases the dopamine by turning a vaccuum into a pump meaning forcing the brain to spit out it's dopamine stores as indicated here in this article

Adderall

While the exact mechanism is unknown, it is believed that Adderall works by blocking the reuptake of dopamine and norepinephrine into the presynaptic neuron and increasing their release from the presynaptic neuron into the extraneuronal space. In other words, Adderall reverses the reuptake mechanism, turning it into a pump instead of a vacuum. Sources note that amphetamine and related compounds (ephedrine, etc.) displace noradrenaline from the presynaptic neuron and do not act as reuptake inhibitors as referenced above.


Now the path ways described here

Dopamine



Anatomy
Main article: Dopaminergic pathways

Dopaminergic neurons form a neurotransmitter system which originates in substantia nigra pars compacta, ventral tegmental area (VTA), and hypothalamus. These project axons to large areas of the brain through four major pathways:

* Mesocortical pathway connects the ventral tegmental area to the frontal lobe of the pre-frontal cortex. Neurones with somas in the ventral tegmental area project axons into the pre-frontal cortex.

* Mesolimbic pathway carries dopamine from the ventral tegmental area to the nucleus accumbens via the amygdala and hippocampus. The somas of the projecting neurons are in the ventral tegmental area.

* Nigrostriatal pathway runs from the substantia nigra to the neostriatum. Somas in the substantia nigra projects axons into the caudate nucleus and putamen. The pathway is involved in the basal ganglia motor loop.

* Tuberoinfundibular pathway is from the hypothalamus to the pituitary gland.

This innervation explains many of the effects of activating this dopamine system. For instance, the mesolimbic pathway connects the VTA and nucleus accumbens; both are central to the brain reward system.[10]
Movement

Via the dopamine receptors, D1-5, dopamine reduces the influence of the indirect pathway, and increases the actions of the direct pathway within the basal ganglia. Insufficient dopamine biosynthesis in the dopaminergic neurons can cause Parkinson's disease, in which a person loses the ability to execute smooth, controlled movements.
Cognition and frontal cortex

In the frontal lobes, dopamine controls the flow of information from other areas of the brain. Dopamine disorders in this region of the brain can cause a decline in neurocognitive functions, especially memory, attention, and problem-solving. Reduced dopamine concentrations in the prefrontal cortex are thought to contribute to attention deficit disorder. It has been found that D1 receptors as well as D4 receptors are responsible for the cognitive-enhancing effects of dopamine. On the converse, however, anti-psychotic medications act as dopamine antagonists and are used in the treatment of positive symptoms in schizophrenia, although the older, so-called "typical" antipsychotics most commonly act on D2 receptors, while the atypical drugs also act on D1, D3 and D4 receptors.

In the OP's case he may simply be unable to produce the dopamine in other wards dopamine depletion from stimulant use is also a possibility but this should resolve after meds are stopped

Tremors are listed as a side effect of this medication and seeing as it effects dopamine it is not surprising - the biggest worry I would have is not the tremors with the medication is if they continued longer than a week or so after the medication was discontinued.
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Old 03-13-10, 02:51 PM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

Lyme should be detectable by blood draw so let us know what you find out . . .
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Old 03-16-10, 07:07 PM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

Just an update, since I said I would: went to my doc and he recommended a rheumatologist for me to see about ruling out any autoimmune diseases. So if you've gotten this far in the thread and you've just started taking Adderall, don't chuck the pills in the trash. There's something wrong with me, not the drug.
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Old 03-07-13, 04:39 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

I was wondering if you got it all worked out and if you are okay? I have the exact same thing now.... I know this is an old post and sorry for bumping it but it is one of the only things that I have found that is very familiar to what I am experiencing.
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Old 03-08-13, 05:25 AM
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Re: Experienced symptoms of Parkinson's Disease after taking Adderall for a few month

You have a Vitamin-B deficiency.

Keep things simple.
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