ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community  

Go Back   ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community > SCIENTIFIC DISCUSSIONS, RESEARCH, NEWS AND EVENTS > Scientific, Philosophical & Theoretical Discussions > Open Science & Philosophical Discussion
Register Blogs FAQ Chat Members List Calendar Donate Gallery Arcade Mark Forums Read

Open Science & Philosophical Discussion This forum is for open discussion, encouraging new and unconventional ways of thinking, welcoming posts in any format

Reply
 
Thread Tools Display Modes
  #1  
Old 08-10-17, 04:10 PM
wonderboy's Avatar
wonderboy wonderboy is offline
Contributor
 

Join Date: Apr 2012
Location: USA
Posts: 276
Blog Entries: 2
Thanks: 120
Thanked 163 Times in 111 Posts
wonderboy has a spectacular aura aboutwonderboy has a spectacular aura about
Exclamation Amphetamine and Pain: pain reception dysfunction and psychopathology

An area of personal scientific interest and inquiry for me is the correlation of possible dysregulation of pain receptors… How we perceive pain, both emotionally and physically, and its correlation, or possible correlation, to psychological disorders, such as major depressive disorder, anxiety disorders, schizophrenia, and ADHD.


It seems to me that most scientific inquiry still studies the antiquated
"Tried and True" serotonin system, along with norepinephrine, and some basic inquiry into dopamine

(expand beyond that, and you will find, very little, as of today)


Although these areas (pain perception and its correlation to psychopathology) obviously can be considered associated with some psychological disorders, more studies are underway to investigate a possible correlation.

The paucity in literature, with respect to substance P, other specific non-discussed, receptors of dopamine, and how the brain -specifically regulates pain- and it's possible correlation with psychological disorders, is a rather new field of study.

You may find someone talking about dopamine, and never heard of substance P


But, many scholars have found that there is a clear model of:

* disrupted emotional and physical modulation of pain and psychopathology *


Faulty modulation correlates, most often, with the following:

____________________________
dorsolateral prefrontal cortex
parahippocampal gyrus,
thalamus, amygdala,
brainstem nuclei ** (Substance P) **
orbitofrontal cortex
____________________________


And..even though this is a very broad statement, the --"limbic system"-- itself.


Some research tends to suggest that Adderall (amphetamine) helps control chronic pain in some individuals, especially those with ADHD, and specifically those who have major depressive disorder, and fibromyalgia in addition to ADHD, through its dopamine altering qualities… (And other mechanisms that we are not even aware of today p.... )


I sincerely apologize if this post was too scientific in nature, too lengthy in both scope and context.


I simply feel this is an area that deserves, highly warrants, more intensive study and research,
as I personally find this area of research fascinating.
Reply With Quote
The Following User Says Thank You to wonderboy For This Useful Post:
mildadhd (08-12-17)
  #2  
Old 08-10-17, 04:59 PM
Wemby AU's Avatar
Wemby AU Wemby AU is offline
Newbie
 

Join Date: Aug 2017
Location: Melbourne, Vic Australia
Posts: 3
Thanks: 0
Thanked 4 Times in 2 Posts
Wemby AU is on a distinguished road
Re: Amphetamine and Pain: pain reception dysfunction and psychopathology

I am on opioids and gabapentin for chronic pain which was the result of a car accident in 2005.
I've restarted Dexedrine about 6 months ago for my ADHD and have experienced the welcome "side-effect" of increased pain relief. So I have been able to halve my daily Morphine intake. I am working with my GP to lower my dosage on a monthly basis with the goal of eventually ceasing the pain meds.
Practical pain management has articles supporting both the stand-alone or concurrent with opioid use of stimulants for chronic pain.



Reply With Quote
The Following 2 Users Say Thank You to Wemby AU For This Useful Post:
mildadhd (08-12-17), wonderboy (08-13-17)
  #3  
Old 08-11-17, 05:46 AM
sarahsweets's Avatar
sarahsweets sarahsweets is offline
Mod-A-holic
 

Join Date: Mar 2011
Location: nj, usa
Posts: 24,129
Thanks: 5,515
Thanked 28,355 Times in 12,788 Posts
sarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond reputesarahsweets has a reputation beyond repute
Re: Amphetamine and Pain: pain reception dysfunction and psychopathology

If I am not mistaken, adhd meds are sometimes used as off label treatment for depression and mood disorders, especially for treatment resistant depression. If someone has chronic pain they almost always have some sort of depression associated with it. So in theory, if stimulants can help with mood, then they can sort of help the way pain manifests right?
__________________
President of the No F's given society.

I carried a watermelon?

I've always been one of a kind. It just hasnt always been positive.
Reply With Quote
The Following 2 Users Say Thank You to sarahsweets For This Useful Post:
mildadhd (08-12-17), wonderboy (08-13-17)
Sponsored Links
  #4  
Old 08-11-17, 07:14 AM
C15H25N3O C15H25N3O is offline
Suspended Account
 

Join Date: Jan 2016
Location: flowstate
Posts: 1,144
Thanks: 769
Thanked 747 Times in 483 Posts
C15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to all
Re: Amphetamine and Pain: pain reception dysfunction and psychopathology

I have a lot of chronic pain from my spinal discs narrowing nerve-channels and forcing pressure on nerves causing spasms and heavy pain like a spinal disc prolapse. Amphetamines indeed can have some positive on nerves by activation but amphetamines also contract muscles which ends in spasm and also can deactivate nerves. If amphetamine was a muscle relaxant no one would ask for a massage. The most important receptor for pain seems to be 5-HT3 of serotonine system which is most affected by psychedelics.

Last edited by Greyhound1; 08-11-17 at 07:01 PM.. Reason: Discussing and promoting prohibited topic per guidelines.
Reply With Quote
The Following 2 Users Say Thank You to C15H25N3O For This Useful Post:
mildadhd (08-12-17), wonderboy (08-13-17)
  #5  
Old 08-11-17, 04:09 PM
Wemby AU's Avatar
Wemby AU Wemby AU is offline
Newbie
 

Join Date: Aug 2017
Location: Melbourne, Vic Australia
Posts: 3
Thanks: 0
Thanked 4 Times in 2 Posts
Wemby AU is on a distinguished road
Re: Amphetamine and Pain: pain reception dysfunction and psychopathology

Quote:
Originally Posted by C15H25N3O View Post
I have a lot of chronic pain from my spinal discs narrowing nerve-channels and forcing pressure on nerves causing spasms and heavy pain like a spinal disc prolapse. Amphetamines indeed can have some positive on nerves by activation but amphetamines also contract muscles which ends in spasm and also can deactivate nerves. If amphetamine was a muscle relaxant no one would ask for a massage. The most important receptor for pain seems to be 5-HT3 of serotonine system which is most affected by psychedelics.

In my experience the relieve of pain has enormous effects on ADHD as pain means a lot of distraction and inattention.
I used to get Magnesium infusions for muscle spasm/contracture, but eventually had too much vein collapse and I started looking like a pin cushion.

Have recently had DRG neruomodulation implant and using ionic liquid magnesium--This is keeping my spasms at bay.

I swear by Magnesium for spasms. But many of the supplements on the market don't work
Natural News has a breakdown of the various types
The Best and Worst Froms of Magnesium to Take As A Supplement

Last edited by namazu; 08-11-17 at 09:11 PM.. Reason: Quoted post was edited in accordance with ADDF guidelines prohibiting promotion of illegal drugs; also fixed broken link.
Reply With Quote
The Following 2 Users Say Thank You to Wemby AU For This Useful Post:
mildadhd (08-12-17), wonderboy (08-13-17)
  #6  
Old 08-12-17, 12:04 AM
C15H25N3O C15H25N3O is offline
Suspended Account
 

Join Date: Jan 2016
Location: flowstate
Posts: 1,144
Thanks: 769
Thanked 747 Times in 483 Posts
C15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to allC15H25N3O is a name known to all
Re: Amphetamine and Pain: pain reception dysfunction and psychopathology

I take magnesium for over 20 years. It is so true most magnesium supplements dont work. Do you have a product link for your ionic magnesium liquid?
I would like to see its chemical contents.

Last edited by namazu; 08-12-17 at 12:38 AM.. Reason: guidelines
Reply With Quote
The Following 2 Users Say Thank You to C15H25N3O For This Useful Post:
mildadhd (08-12-17), wonderboy (08-13-17)
  #7  
Old 08-12-17, 08:12 PM
wonderboy's Avatar
wonderboy wonderboy is offline
Contributor
 

Join Date: Apr 2012
Location: USA
Posts: 276
Blog Entries: 2
Thanks: 120
Thanked 163 Times in 111 Posts
wonderboy has a spectacular aura aboutwonderboy has a spectacular aura about
Re: Amphetamine and Pain: pain reception dysfunction and psychopathology

Thank you for taking the time to read my article and your commentary
Reply With Quote
The Following User Says Thank You to wonderboy For This Useful Post:
mildadhd (08-12-17)
Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump


All times are GMT -4. The time now is 04:00 AM.


Powered by vBulletin® Version 3.7.4
Copyright ©2000 - 2017, Jelsoft Enterprises Ltd.
(c) 2003 - 2015 ADD Forums