ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community  

Go Back   ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community > SCIENTIFIC DISCUSSIONS, RESEARCH, NEWS AND EVENTS > Scientific, Philosophical & Theoretical Discussions > Scientific Discussion
Register Blogs FAQ Chat Members List Calendar Donate Gallery Arcade Mark Forums Read

Scientific Discussion This forum is limited to published/presented scientific research, in a quasi-academic format, with references where appropriate; clear and structured discourse is encouraged

Reply
 
Thread Tools Display Modes
  #1  
Old 02-18-17, 05:24 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
Journal Reports on Effects of Supplements on ADHD, Cognitive Performance, Etc.

This thread is for the posting of journal reports (preferably full text, but abstracts if that is all you can find free of charge) on the demonstrated effects of supplements on ADHD or related cognitive impairments. And, of course, I also mean to invite informed discussion & criticism of the methods and results of such journal reports. There is no intention of trying to limit the scope to only "pro-supplement" interpretations.

However, there are other threads for your general opinions about supplements vs pharma meds, or your experiences with any of the supplements mentioned, so please don't post those here unless you are actually citing research or specifically commenting on cited research.

While mactavish's old 2009 thread is on point, I felt it was getting very long and cluttered, making it hard to focus on finding recent research on supplements, some of which is becoming more interesting with the use of newer imaging technologies and more refined tests of cognitive performance.

As well, I have noticed citations of published research are also sprinkled around many other threads, as well, making them even harder for others to find and compare. So as I come across posts specifically citing published research, credible or otherwise, I would like to repost those here, if that is permissible, so we can start collecting supplement research citations in one place, regardless of the thread in which they initially were posted, or the point originally being made.

Finally when posting supplement research, please include somewhere in the post (1) the names of the supplements referred to so your post will come up in a search of that supplement, and (2) the year of original publication, to make it easier to see what is most recent.

I hope this thread will -- over time-- become something of interest and value to others besides myself. Thank you for your cooperation.
Reply With Quote
The Following 3 Users Say Thank You to 20thcenturyfox For This Useful Post:
Daniel1970 (03-15-19), davidshq (03-04-17), namazu (02-18-17)
  #2  
Old 02-18-17, 05:54 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
If Supplements Can Improve Cognitive Performance in Healthy People...

why are we so sure there is "no benefit" for those with ADHD, depression, etc?

Not really wanting to be a poster girl for supplements (and I realize "research" can often point in different directions until the key processes and interactions are pinned down), but I said I would post a line of research showing fairly modest amounts of ordinary supplements had measurable cognitive effects in healthy people, so here it is.

Kennedy et al 2010 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2885294/
[Berocca= multivitamin & minerals: Vit. C B1 B2 B3 B5 B6 Folic Biotin B12 Calcium Magnesium Zinc see http://www.berocca.com/products/berocca-performance/ ] found small but significant performance improvements in the supplemented group;
White et al, 2016 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5133263/ [MVM=multi-vitamins & minerals: Vit. C B1 B2 B3 B5 B6 Folic Biotin B12 Calcium Magnesium Zinc see Table 1] using fMRI found observable changes in functional brain activity after supplementation, though these were not clearly reflected in corresponding changes in performance (however neither tasks nor sample size were designed to detect small changes in performance).
[plus I recall seeing a study from UK along these lines by somebody named Green that I just can't find at the moment]

Of course both studies leave open the question whether the results reflected suboptimal nutritional status in the study population rather than the value of higher-than-recommended intakes for cognitive tasks. But as long as the supplemented group and the control group were adequately matched and randomly assigned, the improvements in the supplemented group suggest at least making sure you are getting more than the recommended dietary intake of (at least) the common B & C vitamins used in these studies.

Finally I just have to mention one more study supporting supplements--this time for ADHD--that veers into the realm of weirdness by apparently using good RCT methods to study what must be Canada's most controversial supplement, Empower Plus, by Truehope: Rucklidge et all, 2014 https://www.ncbi.nlm.nih.gov/pubmed/24482441

However of the 36 nutrients (I couldn't find a complete list of ingredients, though it reportedly includes 14 vitamins, 16 minerals, 3 amino acids, and 3 antioxidants) in the product, the study monitored blood concentrations of only 9. Of those, the only ones for which the differences between the test and control groups were statistically significant were B6, B12 and Vitamin D (not that any symptom reduction had to come only from the 9).

Between the potential for individual genetic and epigenetic differences now discoverable from gene research and the functional and metabolic data now available from the neuroimaging technologies (such as PET, SPECT, and fMRI), it seems possible that some of the controversy and conflicting data in our understanding of nutrition, drug therapies, and sympton clusters will start to yield some useful treatment guidelines.
Reply With Quote
The Following 2 Users Say Thank You to 20thcenturyfox For This Useful Post:
Daniel1970 (03-15-19), davidshq (03-04-17)
  #3  
Old 02-18-17, 06:38 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
Traditional Oriental Herbal Medicines

This PubMed article was cited in another paper on conventional Western supplements cited by Rockefeller83 (here: http://www.addforums.com/forums/show...2&postcount=58), the article on TOHM being https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538416/

Although the authors were critical of the quality of research they reviewed (most of it claiming TOHM was as effective as methylphenidate), and although they concluded "Currently, there is not strong evidence that TOHM is effective in treating the core symptoms of ADHD....", I thought it was interesting to bring in material published in Chinese, Japanese and Korean language in the 20 years between 1990 and 2010, which (where specified) includes botanical supplements available but not commonly referenced in the West, including Codonopsis Ophiopogonis Rehmannia Schisandra chinensis Scrophularia Glycyrrhiza Acori tatanowii Ginseng Polygala etc. see Table 2).

With newer methods of measuring outcomes, it will be interesting to see what further developments are published in the years following 2010.
Reply With Quote
The Following User Says Thank You to 20thcenturyfox For This Useful Post:
davidshq (03-04-17)
Sponsored Links
  #4  
Old 03-15-19, 02:35 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
Not the Most Recent, But a Good Overview of the Current State of Research

from 2016 a South Korean team published the following review in Neural Plasticity:

Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757677/

What is particularly good about this article is that it not only summarizes results of research on more than 35 "natural" or derived organic substances in relation to ADHD, but gives citations to the other research up to the time of publication. If you are interested in following the large amount of current research published in English on PubMed, this article is the best starting point I have seen.
Reply With Quote
  #5  
Old 03-15-19, 02:44 PM
Daniel1970's Avatar
Daniel1970 Daniel1970 is offline
ADDvanced Member
 

Join Date: Aug 2018
Location: The Sprawl, USA
Posts: 243
Thanks: 222
Thanked 209 Times in 120 Posts
Daniel1970 is a splendid one to beholdDaniel1970 is a splendid one to beholdDaniel1970 is a splendid one to beholdDaniel1970 is a splendid one to beholdDaniel1970 is a splendid one to beholdDaniel1970 is a splendid one to beholdDaniel1970 is a splendid one to behold
Re: Journal Reports on Effects of Supplements on ADHD, Cognitive Performance, Etc.

Have you seen anything of the possible benefits of N-A-C antioxidant as relates to ADHD?
__________________
Consider others. - Sakyong Mipham Rinpoche

Be yourself, and the rest will follow.

Breathing is not optional. - Dr. Raymond Wertheim

What do you care what other people think? - Arline Feynman, to her husband, American physicist Richard P. Feynman

D.
Reply With Quote
  #6  
Old 03-15-19, 03:30 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
Re: Journal Reports on Effects of Supplements on ADHD, Cognitive Performance, Etc.

Quote:
Originally Posted by Daniel1970 View Post
Have you seen anything of the possible benefits of N-A-C antioxidant as relates to ADHD?
So far, only this (and I haven't sprung for the full text, so I can't see the citation for ADHD, but from other reading I think it is only a single case report):

https://www.ncbi.nlm.nih.gov/pubmed/...?dopt=Abstract

NAC has been around for a long time and has other established medical uses. But there is a LOT of research going on regarding NAC and other neuro-cognitive problems like Alzheimers, MCI and Schizophrenia, so I would think they would be closing in on the mechanism(s) of action.
Reply With Quote
The Following User Says Thank You to 20thcenturyfox For This Useful Post:
Daniel1970 (03-15-19)
  #7  
Old 03-15-19, 07:43 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
Taking My Own Advice...to Facilitate Searching by Listing Supplements Referred to...

Quote:
Originally Posted by 20thcenturyfox View Post
from 2016 a South Korean team published the following review in Neural Plasticity:

Natural Product-Derived Treatments for Attention-Deficit/Hyperactivity Disorder: Safety, Efficacy, and Therapeutic Potential of Combination Therapy
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757677/

What is particularly good about this article is that it not only summarizes results of research on more than 35 "natural" or derived organic substances in relation to ADHD, but gives citations to the other research up to the time of publication. If you are interested in following the large amount of current research published in English on PubMed, this article is the best starting point I have seen.
Specific botanicals, vitamins, minerals & other substances named in the above article studied for use with ADHD were:
**Bacopa monnieri
**Ginkgo biloba
Ningdong (a mystery mixture of 4 plants and human placenta--go ahead and laugh, but if I can find it, I will try it!)
*Panax ginseng (Red Korean Ginseng)
*Panax quinquefolium (American Ginseng)
*Passiflora incarnata
**Pycnogenol
Hypericum perforatum (St John's Wort)
*Valeriana officinalis (Valerian)

**Acetyl-L-Carnitine (AlCar)
**Essential Fatty Acid/PUFAs - Alpha-linolenic acid, linoleic acid, Omega-3 fish oils (EPA, DHA,) GLA (blackberry, evening primrose)
**Phosphatidyl-serine
**B6 & Magnesium
*Iron
*Zinc

Oroxylin A (from Scutellaria baicalensis)
Sideritis scardica
**Rhodiola rosea
YY162 (ginkgo/ginseng combo)
*Vitamin C
*Vitamin E tocotrienols
*denotes supplements I currently take or have tried
**denotes those I think have made a positive difference to attention/focus, motivation, sociability or sleep

Last edited by 20thcenturyfox; 03-15-19 at 07:54 PM..
Reply With Quote
  #8  
Old 03-20-19, 03:20 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
2018 Rationale for Dietary Anti-Oxidant Treatment of ADHD

This 2018 Dutch report attempts to synthesize what is known generally about oxidative stress, immune dysfunction, neuron damage, and the microbiome, with studies where these concepts have been applied to trials of various nonpharmacological supplements for ADHD.

I can't evaluate the rigour of their analysis, but the scope of the research and resulting discussion is impressive. It references not only patterns of nutritional status and blood markers in ADHD (Did you know even our cerebrospinal fluid is different?), but also distinctive features of auto-immune, allergic, endocrine, and neurological presentation in ADHD compared with healthy controls and other disorders, and the mechanisms by which dietary elements might operate.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946190/ Rationale for Dietary Antioxidant Treatment of ADHD

Dietary substances mentioned include:Non-enzymatic antioxidants:
GLutathione, Vitamins C, A & E, carotenoids, Co-enzyme Q-10, uric acid, albumin, and bilirubin.
Minerals:
Iron, magnesium, zinc, selenium, copper and lead; also the effect of food additives on the absorption of such minerals (and the fact that there seems to be no research on the effect of prescription medication on these nutritional and blood markers)
Antioxidants:
Epigallocatechin gallate (EGCG), curcumin, Pycnogenol, Baicalin, Ginkgo biloba, Hypericum perforatum (St John's Wort), Passiflora incarnata, luteolin, quercetin, rutin.
Not least of all, there are 173 references to other reports.
Reply With Quote
The Following User Says Thank You to 20thcenturyfox For This Useful Post:
namazu (03-20-19)
  #9  
Old 05-04-19, 09:36 PM
20thcenturyfox's Avatar
20thcenturyfox 20thcenturyfox is offline
Contributor
 

Join Date: Sep 2016
Location: Canada
Posts: 380
Thanks: 1,292
Thanked 453 Times in 250 Posts
20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light20thcenturyfox is a glorious beacon of light
Randomized Double-Blind Trial of Pycnogenol on ADHD in Progress

(duplicate post from another thread which seemed to belong here as well

According to this report (also cited elsewhere) there is now a Dutch investigation of Pycnogenol for ADHD (compared with methylphenidate and placebo) in progress: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370458/

I gather they are proposing to start patients in the Pycnogenol arm at 20mg and titrate up up 1mg per kg body weight (so depending on your size, 60mg could be a little light). The test period runs for 10 weeks.

The secondary outcome measures are exceptionally broad and detailed (including even analysis of participants' microbiota). Whatever the results, this is shaping up to be a very informative study.
Reply With Quote
The Following User Says Thank You to 20thcenturyfox For This Useful Post:
namazu (05-04-19)
Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
ADHD: Underdiagnosed and Undermedicated? APSJ Science in the Media 17 01-13-17 06:20 AM
Journal Reports on Psychosocial Treatments for ADHD 20thcenturyfox Scientific Discussion 1 11-11-16 08:16 PM
50 Conditions that Mimic ADHD dude102 Adult Diagnosis & Treatment 6 06-18-12 03:24 AM
My NEW ADHD Research Summary: Out of Pure Frustration With Lack of Current Knowledge! MedStudent82 Ritalin 11 05-26-12 02:34 AM
19, new here, just started adderall, lots of questions, long.. mistaben Adderall 30 10-05-08 01:06 AM


All times are GMT -4. The time now is 01:54 AM.


Powered by vBulletin® Version 3.7.4
Copyright ©2000 - 2019, Jelsoft Enterprises Ltd.
(c) 2003 - 2015 ADD Forums