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General Medication Discussion This section is to be used for general medication discussion and other medications not broken out in their own respective forums.

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  #1  
Old 11-12-15, 04:08 PM
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Conversion Factors for Common ADHD Medications

The following equivalencies can be used to contrast and compare the relative potency of different
ADHD-related medications and their dosages, per their base chemistries as derived from their various salts
(as found in the medication when taken).


Here are base equivalencies for common amphetamines used in clinical treatment of disorders, all of which are CII controlled substances:

10mg mixed amphetamine salts (Adderall) = 4.747mg dextroamphetamine base, 1.506mg levoamphetamine base
10mg dextroamphetamine sulfate (Dexedrine) = 7.333mg dextroamphetamine base
10mg lisdexamfetamine dimesylate (Vyvance) = 2.966mg dextroamphetamine base
10mg amphetamine sulfate (Evekeo) = 3.666mg dextroamphetamine base, 3.666mg levoamphetamine base
10mg methamphetamine hydrochloride (Desoxyn) = 4mg dextromethamphetamine base, 4mg levomethamphetamine base

Here is a more detailed breakdown of Adderall, for each of its constituent salts, as found in a 10mg pill:

25% dextroamphetamine sulfate = 1.833mg dextroamphetamine base
25% amphetamine sulfate = 0.916mg dextroamphetamine base, 0.916mg levoamphetamine base
25% dextroamphetamine saccharate = 1.408mg dextroamphetamine base
25% amphetamine aspartate monohydrate = 0.590mg dextroamphetamine base, 0.590mg levoamphetamine base

Here are base equivalencies for methylphenidates used in clinical treatment of disorders, all of which are CII controlled substances:

10mg methylphenidate hydrochloride (Ritalin, Concerta) = 4.350mg dextromethylphenidate base, 4.350mg levomethylphenidate base
10mg dextromethylphenidate hydrochloride (Focalin) = 8.700mg dextromethylphenidate base

All values have been rounded to three decimal places.

Sources:

Wikipedia page for Amphetamine: https://en.wikipedia.org/wiki/Amphetamine
U.S. Dept. of Justice, DEA Office of Diversion Control, page for Conversion Factors for Controlled Substances: http://deadiversion.usdoj.gov/quotas...tor/index.html
PubChem page for methamphetamine: http://pubchem.ncbi.nlm.nih.gov/comp...ethamphetamine


Cheers,
Ian
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Old 05-25-17, 07:23 PM
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Re: Conversion Factors for Common ADHD Medications

this stimulant equivalency chart may be helpful:


http://www.uacap.org/uploads/3/2/5/0...quivalency.pdf
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Old 04-29-18, 06:36 AM
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Re: Conversion Factors for Common ADHD Medications

10mg lisdexamfetamine dimesylate (Vyvance) = 2.966mg dextroamphetamine base

^^^ Is this saying 10mgs of Vyvanse corresponds with 2.966 IR Dex? Vyvanse lasts longer than IR Dex, so is it saying that at any one time, the experience of Vyvanse is equivalent to 2.966 IR Dex (which in that case, because Vyvanse lasts longer, it would probably include a few redosing of the IR Dex, making total mgs higher than 2.966)?

Sorry, I probably could have worded that better. Thanks for any clarification.
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Old 04-29-18, 09:07 AM
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Re: Conversion Factors for Common ADHD Medications

No, because you have to match the dextroamphetamine base in each to find the equivalent dose.

10mg Vyvanse is equivalent to ~4mg Dexedrine.

This is because mg per mg, Dexedrine is almost 2.5x as strong as Vyvanse.

I would have to take 150mg of Vyvanse to equal my Dexedrine dose.


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Ian
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Old 05-02-18, 05:05 AM
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Re: Conversion Factors for Common ADHD Medications

Quote:
Originally Posted by aeon View Post
No, because you have to match the dextroamphetamine base in each to find the equivalent dose.

10mg Vyvanse is equivalent to ~4mg Dexedrine.

This is because mg per mg, Dexedrine is almost 2.5x as strong as Vyvanse.

I would have to take 150mg of Vyvanse to equal my Dexedrine dose.


Cheers,
Ian
Oh.. read the chart too quick.. thanks. The other point of confusion is the 10mg Vyvanse... the 4mg Dex base in that is spread out over a greater period of time because Vyvanse lasts so much longer so the experience of it wouldn't be the same as taking 4mg Dex IR. I'll have to work that out via trial and error. Thanks again for correcting my dumb mistake.
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Old 05-02-18, 09:55 AM
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Re: Conversion Factors for Common ADHD Medications

Quote:
Originally Posted by adhdseeker View Post
Oh.. read the chart too quick.. thanks. The other point of confusion is the 10mg Vyvanse... the 4mg Dex base in that is spread out over a greater period of time because Vyvanse lasts so much longer so the experience of it wouldn't be the same as taking 4mg Dex IR. I'll have to work that out via trial and error. Thanks again for correcting my dumb mistake.
10mg Vyvanse has 2.966mg of dextroamphetamine base.

My experience of Vyvanse at the typical clinical dosage was that it didn’t do much at all because the rise time was so slow, and the eventual peak plasma was so small.


Cheers,
Ian
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Old 05-02-18, 01:40 PM
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Re: Conversion Factors for Common ADHD Medications

Here is a quick and dirty conversion chart for the usual amphetamine-based ADHD medications, rounded to the nearest whole number.

Your dose on the left, the equivalent dose for the other two meds in the next two columns.


amphetamine_equivalencies by aeon314159, on Flickr


Cheers,
Ian
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