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Old 05-22-18, 01:01 AM
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All disease is preventable

I’ve been trying to synthesize as much of the literature that I’ve been able to absorb.
Please can I ask for opinions ?


The conclusion (just copied from the end of this email)
ALL disease results from the way that we live our lives and is wholly preventable (as stated by Hippocrates).

As stated by Hippocrates (‘let food be thy medicine’).

Hi ...
Thanks for your interest in our work. What we have found is that fresh foods, including meat and vegetables, do not contain PAMPs (which stimulate TLRs and inflammation). However, when you chop them into small pieces (such as grated carrot or minced meat), this provides a large surface area for bacteria to grow on. This is what we mean by processed - ie anything which has been chopped into small pieces and stored for some time. PAMPs accumulate only very slowly on a large steak, but very quickly in minced meats, because a certain type of bacteria grows quickly in the minced meat. The same thing is true for some vegetables, particularly onion. There is no problem with most fermented goods, such as yoghurts and probiotics, since those bacteria do not release their PAMPs.
Regards,
author name removed

And then from PLOS one recently
Endotoxin in the Diet Impacts the Level of Allergic Sensitization in Germ-Free Mice (PLOS one 2017)
Alongside

Factors result in Intestinal permeability and alters the composition of the gut microbiota, allowing bacterial components from the gut lumen to reach the systemic circulation.
Changes in intestinal tight junction permeability associated with industrial food additives explain the rising incidence of autoimmune disease

https://www.sciencedirect.com/science/article/pii/S1568997215000245


Diseases of Western living caused by -> processed food (high in endotoxin) + process food increase intestinal permeability lead to gut microbiome (bacteria) entering blood stream -> LPS/induced IL-1/TNFa -> pro-inflammatory environment -> Inflammation (commonality underlying all diseases of Western living) -> diseases of Western living.

There's much more to the idea but I'll just list the first ten parts to the idea which come to mind.
1. Psychological distress -> chronic glucocorticoid (cortisol) / adrenaline production and resistance
2. Processed food -> chronic glucocorticoid and mineralocorticoid resistance
3. Loss of prebiotic/probiotic -> reduced gut biomic diversity -> loss of butyrate-producing bacteria
4. Butyrate -> HDAC inhibitor (anti-inflammatory)
5. High meat diet (umami)/High dairy diet (casein)/High Wheat diet(gluten) -> Glutamate rich
6. Glutamate -> excitotoxin
7. Reduced GABA (organic low GI vegetable diet) increased Glutamate (Western diet)
8. Optimally diverse gut biome -> synthesis of feelgood neurotransmitters (95% serotonin produced in gut)
9. Fasting -> b-hydroxybutyrate (like butyrate) -> pro-GABA neurotransmitter (relaxation cf benzodiazepenes)
10. Pesticides destroy gut biome (increased intestinal permeability) eg organophosphate class eg https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096588/

Lots more - but to cut to the chase - the entire family of Western disorders are caused by the Western lifestyle. So - psychological distress (from the life people lead as described on 'rat park' underlies physiological distress (as described in 'rat park') as a depressed population requires stimulant (blood glucose elevation and glutamate) to get by.
There's lots more to the idea eg [next ten ideas to come to mind] (1) Mitochondrial ROS generation under stress (2) Anti-oxidants in proper food are protective (particularly herbs and spices) (3) Mitochondrial biogenesis through lifestyle (4) Psychological distress eliminated by simple definition of what a mind is for (ie morality) (5) IL-1/TNF-a -> operate through c-fos/c-jun ie 'early gene response' (6) Cortisol resistance proven to occur through chronic stress (Cohen,2012) (7) cellular oncogenes (like viral oncogenes) trigger cellular growth -> de novo (not salvage pathway) purine/pyrimidine synthesis (8) I've found that caffeine treats my asthma (adenosine antagonist) ie same as switching from de novo supportive (remove endotoxin/LPS in bloodstream) to salvage pathway (9) Fasting also treats my asthma -> autophagy and stem cell renewal (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102383/) (10) Positive effects of b-hydroxybutyrate and butyrate on mood / mood swings / epilepsy.

... ... ... I think I've captured nearly every aspect of life, that I can ... ... but the conclusion turns out to be the Western lifestyle causes the diseases of Western living ?

Trying to make the conclusion a little simpler - that distress on a few different levels (particularly psychological stress through having meaningless goals in life) leads to a chain of events in which inflammation and pre-mature ageing to the diseases of Western living occur ?

I've had to read hundreds of job adverts today so 'got' to see what everybody was doing,
The trigger came when I saw (1) Methotrexate -> treats cancer and auto-immune disease (2) Steroid -> treats cancer and auto-immune disease (3) HDACi -> treats cancer and auto-immune disease (4) The new 'biologics' (anti-TNFa/IL-1) treat cancer and auto-immune disease ie the four of them can be connected in the scheme above (1) DHFR inhibition by methotrexate above (mechanism of operation of caffeine to alleviate my asthma) (2) section on cortisol/adrenergic resistance (reason why b-adrenergic agonists and prednisolone cure my asthma) (3) section on (b-hydroxy) butyrate above (reason why fasting treats my asthma) (4) section on endotoxin/LPS above (note infections trigger asthma).

Just to continue - that basic idea has been 30 years in the making and comes down to the first proper essay I wrote in my first degree.

Simply: IL-1/TNFa -> c-fos/c-jun versus Glucocorticoid Response Element <- cortisol
(+) -> <- (-)

So - IL-1 drives proliferation and cortisol calms proliferation.

Can't we simply call pathology NOT physiology ?
We've spent much time working out how to treat pathology but wouldn't maintaining physiology work ie the prevention rather than cure approach ?

Physiology is maintained if Mineralocorticoid/Glucocorticoid aren't called on (ie the body is ticking over nicely and the internal environment is untroubled).
c-fos/c-jun [anabolic] -> <- steroid (made from chaining acetate or small chain fatty acids together)
Ins/IGF-1 (anabolic) -> <- leptin
carb -> <- fat
ancient -> <- modern fuel
growth -> <- maintenance/differentiation

ie what we have in human development is a shift from growth to differentiation - however it fails (the emails yesterday on psychological distress driving a growth promoting internal environment which leads to

  • over-growth (inflammation underlying all common disease),
  • mutation ie somatic mutation in developmental disease/cancer (as growth rate exceeds our capacity to error check),
  • infectious diseases (since the immune system is now dysregulated) (eg https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3341031/),
  • neurological development (eg https://www.sciencedirect.com/science/article/pii/S0091302218300098) connecting to learning disorders
  • even mental disorders (the valproic acid model of autism and the Dutch Hunger Winter leading to schizophrenia) can be accommodated.

    So ... I guess I'm asking whether we can identify the same basis to polygenic, monogenic, infectious, learning disability and mental disorders - as (in effect) the consequence of psychological distress from living a life which is incompatible with the mind ie not personally satisfying ?

    The Western disorders of living are a result of the way that we live our lives ?
    Or more simply ALL disease results from the way that we live our lives and is wholly preventable.
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Old 05-22-18, 01:06 AM
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Re: All disease is preventable

Lots more to follow if required - but that should be a unifying model of ALL human disease - and it's trivial.
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Old 05-22-18, 02:04 AM
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Re: All disease is preventable

It's a psychosocial model - where an absence in motivation in life cascades down into a society of profiteering thicko pharmaceutical companies that try and take advantage of - instead of work to help to understand in order that we might prevent disease.
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Old 05-22-18, 02:06 AM
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Re: All disease is preventable

The sad thing is - is that all of the above is obvious.

Note - attention deficit disorder - there's nothing wrong with people that cannot pay attention to nonsense - we've a higher calling - to learn (actually learn as in make ourselves better) - and this does not happen in establishment learning organizations - which're more like hierarchical corporations - with the King up above and all those that would be King competing below.

All disease can be prevented by global social change.

I will connect ALL mechanisms (which exist from the Big Bang to the mechanism of enjoyment of quality) into this one idea if required.
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Old 05-22-18, 06:35 AM
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Re: All disease is preventable

Back to development

TNFa -> <- TGF series
...........|
...........^
...........|
......cortisol

So

growth -> <- differentiation
growth ->|
growth ->^
growth ->|
grow aerobic respiration

ectoderm -> mesoderm <- endoderm
Mesoderm - connective tissue operating alongside integrin family.

Integrin triggered differentiation

So - the goal is completion in development ie to complete growth (TNFa) and differentiation (TGFB) and to settle into a life of not needing to call on glucocorticoid and mineralocorticoid ie physiological maintenance.

Relationship between cortisol and mitochondria
Mitochondria happiest when blood glucose levels remain constant ... ... 'Hyperglycemia-induced overproduction of superoxide is the causal link between high glucose and the pathways responsible for hyperglycemic damage.'
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Old 05-22-18, 06:38 AM
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Re: All disease is preventable

Summarising

Human beings have a program of growth/differentiation - but as soon as we're physically built - we're supposed to be characterized by neuronal assembly (learning) ... ... ... not continuing growth / differentiation.

So - to breathe, learn and to become personally better.

Stage 1 - growth/development
Stage 2 - Human beings learn - first understanding, morality and then sensory information sensitivity.

Stage 2 requires a state in which neurones re-arrange ... ... the stress-free normoglycaemic state.
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Old 05-22-18, 08:31 AM
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Re: All disease is preventable

so a woman who gets hereditary ovarian cancer is only getting it due to western diet/living?
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Old 05-22-18, 08:35 AM
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Re: All disease is preventable

Thing is - is that nobody makes any money if human beings are healthy.

So no money it will have to be.
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Old 05-22-18, 08:40 AM
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Re: All disease is preventable

Quote:
Originally Posted by sarahsweets View Post
so a woman who gets hereditary ovarian cancer is only getting it due to western diet/living?
That's the model.

Remember little cancer in a genetically heterogeneous population of monks on Mount Athos.
No other cosnequence - lifestyle related.

40% of cancers with an obesity component.
https://www.cdc.gov/media/releases/2...r-obesity.html

40% eliminated with no obesity without citing any form of more novel science.

The writing is on the wall as soon as we generate a direct connection between obesity and cancer.

Where the connection between Alzheimer's and Type II Diabetes is equally stark.

So - psychosocial stress underlies a chain of events which give rise to all disease.

There's nothing wrong with people as long as we grow up in an environment without psychosocial stress.

It's all fairly obvious - and appearing in standard medical journals it seems.

Focus on the idea that NOBODY doubts that diabesity is a wholly preventable condition.

https://www.bmj.com/rapid-response/2...d-good-doctors
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Old 05-22-18, 08:44 AM
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Re: All disease is preventable

It's a de novo mutation generating environment that we're looking at in the case of eliminating hereditary cancer.

Remove the environment - and you're away.

Out-breed.

But none of that is particularly important - we're talking in effect about a complete elimination of disease (perhaps it'll take a couple of generations) with a moral collective environment in which people do not suffer from chronic distress.

Recessive disorders may still occur with in-breeding however we have out-breeding and useful screening strategies ready to alert us to the presence of trouble thanks to the machine that's scheduled for arrival.

Nova (Illumina) has risen.
https://emea.illumina.com/systems/se...s/novaseq.html

It really is obvious to all those who have tried to understand the human body - it is too sophisticated to fix if it breaks - we need to operate it according to manufacturer's instructions - easily definable by working out what causes distress. What causes eustress - and to increase eustress and decrease distress.
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Old 05-22-18, 08:50 AM
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Re: All disease is preventable

--- Summarising once again ---
The Human being is special in that the human being is supposed to have a mind.
There is no mind unless the human being is educated (to display morality) which culminates in wisdom.
A wise individual within a wise society won't be distressed.
Distress -> leads -> to a series of downstream consequences which lead to disease.

Note that aspects like processed food, absence in Vitamin D exposure, workplace depression through bullying ... ... ... are all removed and hence the diseased state is prevented by the interventions shown above.

So - you might say - what about the army veteran with PTSD ?
Solution - war is not what happens when a wise individual is in a wise society.

What about the guy who gets knocked over by a car ?
Fossil fuel based displays of status (the car) are not what happen when we've wisdom in a wise society

You get the picture ?
We're talking about the fundamental aetiology of ALL disease - even though disease will (eg above) be a couple of steps removed from 'moral individual in wise society'.
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Last edited by SB_UK; 05-22-18 at 08:55 AM.. Reason: ...
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Old 05-22-18, 08:57 AM
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Re: All disease is preventable

As mentioned above - we've a competing duality of
+ -> <- -
and as mentioned throughout - it's when the competing duality settles into basal balance - that we reach a point at which the individual is complete (wisdom) and is satisfied to live without the need for the highs and lows of the blood glucose elevation (pleasure/pain) paradigm.
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Old 05-22-18, 09:03 AM
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Re: All disease is preventable

Think about it another way - the introduction of mutation will obviously occur when replication rate is 'speeding' - pull it all the way back - and mutation rate will decrease. That should be an easy argument to comprehend.

Also - powerful argument in that the basal balance of aerobic respiration will feature low mitotic rates - the telomere (our candle) ceases to burn down.

All diseases occur as a consequence of people without morality living in a global society without morality. A mindless individual in a mindless environment.

DEFINITELY.
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Old 05-22-18, 09:11 AM
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Re: All disease is preventable

Quote:
And once cells start growing too fast, they are more likely to pick up further mutations and less likely to be able to repair the damaged genes.
That's the idea ^^^

http://www.cancerresearchuk.org/abou...-cancer-starts

-*-

DNA Repair if the scheme above is followed.
If the cell is driven away from growth/differentiation.
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Old 05-22-18, 09:15 AM
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Re: All disease is preventable

So - I'm suggesting that the psychosocial model eliminates the biomedical model of medicine - but really - does anybody who has looked at how complicated human beings are ? from epigenome to gut biome, from global transcription pattens to histone modification, from neural arrangement to the glycocalyx - ACTUALLY ??? think we could 'fix' it if it goes wrong.

What complete nonsense.
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