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General Medication Discussion This section is to be used for general medication discussion and other medications not broken out in their own respective forums.

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Old 01-13-18, 07:59 AM
Barbrady1 Barbrady1 is offline
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Question Amphetamine vs Methylphenidate

Is there any substance to the claims that amphetamine-based medications work better for those with ADHD P-I?

I have been diagnosed with the combined-type but definitely identify more with the symptoms of the predominantly inattentive type of ADHD. Whilst I had a poor response to Vyvanse yet a good response to Ritalin, I do keep reading that the inattentives among us generally benefit me from lower doses and amphetamine stimulants.

It would perhaps be encroaching but I do believe it would be interesting to learn what everybody's formal diagnosis is and which medication (if any) gave them the greatest relief from their respective difficulties.
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Old 01-13-18, 10:30 PM
CharlesH CharlesH is offline
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Re: Amphetamine vs Methylphenidate

I think it's mostly anecdotal - there isn't a whole lot of research that directly compares the two classes in clinical trials (no financial incentive for pharma companies). It's mainly about establishing effectiveness over placebo in order to get FDA approval. Generally, AMP and MPH are both considered first line treatment, with some experts thinking that AMP tends to have slightly higher success rates (but it's still trial and error for each individual patient!).

In theory, when it comes to the ratio of dopamine to norepinephrine effect, MPH has a higher ratio of dopamine effect, and AMP has a higher ratio of norepinephrine effect. Dopamine is theorized to help more with hyperactivity/impulsiveness, and norepinephrine is theorized to help more with inattentiveness. I don't have specific links to scientific literature with me right now, but this is standard scientific theory (which is just that...theory! More research needs to be done!)
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