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Scientific Discussion This forum is limited to published/presented scientific research, in a quasi-academic format, with references where appropriate; clear and structured discourse is encouraged

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  #1  
Old 08-10-18, 08:11 AM
SB_UK SB_UK is offline
 
 

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SEN-EMP-SYS from Autism Research Centre

Defining the mind

https://www.autismresearchcentre.com/people_baron-cohen

https://www.autismresearchcentre.com/project_3_sensory
https://www.autismresearchcentre.com/project_1_empathy
https://www.autismresearchcentre.com...ct_2_systemize
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  #2  
Old 08-10-18, 08:23 AM
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Re: SEN-EMP-SYS from Autism Research Centre

SEN-EMP-SYS relating to the levels of sensitivity [neocortical properties] which ADDer exhibits.

The key issue is that one need develop all 3 together.

Not become a specialist in one.

Sen (infinite series of patterns - an infinite series of binary constructs)
Sys (limited series of patterns to the rules of maths)
Emp (more limited series of patterns to the rules of words)

Pattern matching informational streams to 'rules'.

What determines whether an informational stream is well greeted ?

Elegance.

Elegance is a lovely word and defines what the mind wants.

To develop elegance in all things neocortical.
The word matches with but surpasses quality,excellence, creativity - in that it fits in context of natural language usage.

To hold oneself elegantly - elegant code - elegant prose.

sensory perception - the elegantly dressed female
cognition - elegance (an idea which changes everything)
generation of motor commands - elegance in posture
spatial reasoning - elegance in design
language - elegance in choice of words

ADDers are elegance adapted.

What is elegance from a more scientific perspective ?
Information organization.

In the case of an elegantly designed caravan - no space is wasted and everything that's required is within easy reach.

-*-

What is elegance ? Elegance is the art of sculpture of potentiality into reality.

What is the goal of elegance ? To generate the most efficient form and then to scale it.

ie to generate the optimal brick and then to build a house.

-*-

Summary
Lovely Simon Baron Cohen defines Sen-Emp-Sys as the three highest factors of concern autism list.

The psychiatric disorder spectrum provides us with an understanding of mind - since people within it are (now) - thanks to the change of perspective offered - seen as hyper-functioning in the SEN-EMP-SYS channels ie hypersensitive - as the next logical progression in the evolution of man.

We are gifted through:
Dutch Hunger Winter pregnant mother -> schizophrenic child
valproic acid model of pregnant mother -> autistic child

To see that ketone (or ketone-like) molecules drive heightened sensitivity in neocortical systems.

This is important.

It teaches us the importance of the need for a transition in metabolic state during the defined human life cycle.


Birth -> Endocrine development through birth to pair-bonding to wisdom -> mid-30s
---------transition from glycolysis to ketone-----------------------------------------------

The basis to healthy ageing.

Have you made a mistake ?
I can't decide between ketone adapted from birth and ketone adapted from wisdom.

What happens when one fasts ?
Extremely heightened senses.

Ketosis would select for heightened sensory capacity noting .. ... ... let's look.
Quote:
Our findings suggest that plasma levels of serotonin, BDNF and NGF were significantly increased during fasting month of Ramadan.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505095/
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ADHD understood - simple matter of defining purpose (morality) of mind
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Last edited by SB_UK; 08-10-18 at 08:52 AM..
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  #3  
Old 08-10-18, 08:56 AM
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Re: SEN-EMP-SYS from Autism Research Centre

We have a definite fight here between

Body growth [mitosis] and Mind growth [information recognition]

Gourmand vs Gourmet

But the secret appears to be
FASTING
DIET WHEN NOT FASTING [veggies + certain profile of oils]
EXERCISE [resistance + endurance]

All possible for next to no cost.

Experimental design for proof (of precancer reversal) - in personal gallery on site.

Examine the effects of ketosis on whole epi/genomic variability - it'll work in animals.

no animals need be hurt - just food and taking a little blood.

What will we find ? Reduced derangement of the genome by metabolic state.

Is it obvious that this will occur ?
Yes - it is obvious.
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Old 08-10-18, 10:33 AM
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Re: SEN-EMP-SYS from Autism Research Centre

Quote:
Originally Posted by _ View Post
Have you made a mistake ?
I can't decide between ketone adapted from birth and ketone adapted from wisdom.
I can't see how evolution would lead to people who can handle
-- eating too much
-- overcranking glycolysis (increasing blood glucose levels)
-- overeating protein (increasing blood urea levels)
-- overeating pretend food (increasing blood salt levels)

Calculated osmolarity = 2 Na + 2 K + Glucose + Urea ( all in mmol/L).

Quote:
Acetoacetate and 3-hydroxybutyrate are short-chain (4-carbon) organic acids (Figure 1) that can freely diffuse across cell membranes IE No transporter mechanism as we see in salt and glucose and protein/amino acid
https://www.diapedia.org/metabolism-...ody-metabolism

So - no transporter mechanism - no effects on osmolarity/electrophysiology.

Impaired glucose clearance (as more and more people develop TIID earlier).
Increased plasma osmolarity.
Water flow from cell -> extracellular space.
Change in intracellular ionic concentrations.
Mitochondrial stress since mitochondria need constant ionic gradients.


Human beings only need 1 thing to survive.

Food -> heat + energy via mitochondria

It is hard to believe that we'd be built to do anything more than survive on little.

Why ? mitochondria rely on membrane potentials.

-*-

Do the ketone bodies have any adverse effects ?
Ketoacidosis tendency ?
So - need an alkalizing diet.

Fresh vegetables.

-*-

Kidney - challenged since role to remove urea, glucose, salt from blood.
link 1
https://image.slidesharecdn.com/5094...?cb=1343336703

Acidifying foods result in acidified urine
link 2
https://www.healthline.com/nutrition...-myth#section3

Overworked kidneys will most likely not do their job - acidification in blood stream
link 3
'At the onset of diabetes, the kidney grows large and the glomerular filtration rate (GFR) becomes disturbed.'
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3083882/

-- but not a problem if glucose/urea/salt eliminated and alkalizing foods consumed.

ie acidification compensated by products of 'burning' vegetables.

note - as covered previously - principle of calorimetry ie burning (as in setting on fire) food - the human body literally burns food but in a controlled way [the electron tranport chain] - and so must leave ash.

Mitochondrial operation is controlled burning (in the sense of setting on fire).

---Summarising---
Simple 16 year old biology of osmosis [mechanism and determinants of plasma osmolarity], membrane potentials, kidney operation, mechanism of calorimetry, mitochondrial operation and pH ... ... provide us with the clear view that a metabolic state centred on ketone is optimal for mitochondrial function and it needs to be performed in a manner (discounting Atkins as this is an acidifying diet) which alkalizes to counteract the acidifying effects of ketone bodies as seen in the exaggerated ketoacidosis state.
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ADHD understood - simple matter of defining purpose (morality) of mind
See Stabile 'enforced moral consistency' ~15 years ago, nothing else since has been of any relevance to ADHD.

Last edited by SB_UK; 08-10-18 at 10:55 AM..
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  #5  
Old 08-10-18, 10:57 AM
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Re: SEN-EMP-SYS from Autism Research Centre

Connecting

A central paradigm for disease.

Materialism -> Immaterialism
Industrial -> Informational

Money -> Money-free society required for human beings to swear allegiance to elegance, quality, beauty, creativity and wonder.

Neocortical SEN-EMP-SYS quality desperately desired by man.

Human beings LEARN.

but what about big data ?
It's all nonsense.

You just need to think about it.

Why did people not think about it ?
People did not want to leave their molecular speciality.

You need to visit EVERY aspect of reality from musical lyrics to Picasso's images of '3d' people in 2d.
Narrow-sense academia makes Narrow overarching sense.

'Nothing is real and there's nothing to get hung [up] about'
to
There are only 2 spatial dimensions - just as a sheet may be tucked over a supposedly '3d' object to emulate it.
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ADHD understood - simple matter of defining purpose (morality) of mind
See Stabile 'enforced moral consistency' ~15 years ago, nothing else since has been of any relevance to ADHD.

Last edited by SB_UK; 08-10-18 at 11:14 AM..
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