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Old 09-02-12, 02:34 AM
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ADHD due to too much dopamine

I was diagnosed due to ADHD. Adderall doesn't work on me. I just become even more hyper and manic. Is it possible to have ADHD symptoms due to too much dopamine and too little serotonin (chronic depression due to genetic factor)?

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Old 09-02-12, 02:35 AM
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Re: ADHD due to too much dopamine

It is possible that you are bipolar.


Just throwing that out there.
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Old 09-02-12, 02:47 AM
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Re: ADHD due to too much dopamine

On top of ADHD and social anxiety diagnoses. My differentials for other symptoms were depression, PTSD and bipolar 2. But I don't think I am bipolar. I am easily irritable but I never felt depressed unless there is a traumatic event. I am usually hyper but never depressed or moody. I do feel lonely when I am by myself but that's all. My girlfriend, my close friends and family tell me there is no way I fit the bipolar 2 description. However, adderall does make me feel like I am bipolar, but that's secondary reaction to adderall. Not sure what to take from this though...
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Old 09-02-12, 03:22 AM
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Re: ADHD due to too much dopamine

Try ritalin or concerta. Sometimes amphetamines relax me, sometimes they overshoot the goal and make me a little manic. Ritalin slows me down perfectly, and it's never given me the manic symptoms I can get on dexedrine.

Also try reducing your dose. A dose that's too high can make your symptoms worse.
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Old 09-02-12, 04:39 AM
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Re: ADHD due to too much dopamine

Theres some research into using dopamine antagonists in the treatment of ADHD, to prevent aggression, and to sensitize the dopamine receptors:

"Stimulants are widely considered the first-line treatment recommendation for ADHD because of their high reported success rate.21 However, atypical antipsychotics have been shown to treat ADHD symptoms.2225 Specifically, risperidone was shown to improve attention and hyperactivity,26 and aripiprazole has been shown to improve cognitive functioning"
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2898838/

Not saying I would try an anti-psych ever though, scary side effects.

Its so much trial and error. You can always try just a ssri for a while too if you really think its depression and have alot of sadness. I'm also gonna quit adderall though (probably) because it makes me hyperfocus too much.
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Old 09-02-12, 11:33 AM
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Re: ADHD due to too much dopamine

Unfortunately, my doc won't prescribe SSRI to me because of possible hypomanic episode due to bipolar 2 differentials. I understand her concern. I've been on St. John's wort for past week instead. SJW has an immediate effect on me (within 45 minutes) like mood lift and alertness lasting the whole day even from day 1. I don't necessarily focus better though...
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Old 09-02-12, 11:43 AM
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Re: ADHD due to too much dopamine

Okay, I don't practice on the net, nor am I qualified to prescribe.

Here's my (very limited) take on this.

Adderall and Ritalin (reportedly) have different actions on Dopamine, which appears to

be in regards to the length of one of the Dopamine related genes. I think it's the

receptor gene, but it might be the transporter. I haven't looked at this in a long time.

What I recall is that they (meds) impact the dopamine "pump" differently. For example,

Adderall creates more dopamine, while Ritalin "sucks up" the extra amount.

Once again, this is outside my element, so I claim no expertise.

Either way, good luck to you.

tc

mctavish23

(Robert)
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Old 09-02-12, 05:26 PM
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Re: ADHD due to too much dopamine

That's an interesting theory. Adderall actually calms me down and takes away my manic hyperactivity, so I feel more relaxed and content than euphorically happy. So I wonder if increasing my dopamine levels out my other brain chemicals or if it just regulates how much dopamine it puts out?

It could be that you are taking too much. People that abuse adderall take it for the euphoric high that you just described.

Or maybe you need a non-stimulant medication.
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Old 09-02-12, 06:47 PM
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Re: ADHD due to too much dopamine

I take 5mg adderall, my bp goes up and I get hyper. at 2.5mg, I don't feel anything. 5-HTP calms me and gives me more focus. St. John's wort gives me euphoria that is comparable to 10mg adderall pretty much within 45 minutes after ingestion without waiting 4-6 weeks. Not sure what to take from these results. I don't think I need a stimulant.
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Old 09-02-12, 09:03 PM
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Re: ADHD due to too much dopamine

All you can conclude from your response is that you are sensitive to meds. Everyone has a different med "window" and it has nothing to do with whether or not you have ADHD. I'm also very sensitive to meds, it's harder for us to work out our correct med and dose because we have such a narrow window of effectiveness.

Again, I'd try ritalin first. I responded to amphetamines in much the same way as you. Ritalin is half as potent as adderall, so you'll have more room to figure out what the correct dose is. Ritalin is also much more calming to me.
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Old 09-03-12, 06:30 AM
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Re: ADHD due to too much dopamine

SJW and 5HTP are both good supplements to take if youre low on serotonin, rather than dopamine.

Additionally, you could look into medications that affect your noreprephine (noradrenaline) levels, which is the third major neurotransmitter. Strattera for example works by affecting this transmitter rather than dopamine, and Wellbutrin also partially affects noreprephine. If traditional ADHD meds, which are dopamine focussed, dont work for you, you might want to try these.
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