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  #1  
Old 01-08-12, 01:37 PM
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Clonidine | Guanfacine | Propranolol

I have co-morbid anxiety along with my ADHD and I believe that stimulants may exacerbate my nervous habit (psychomotor agitation) but the pros outweigh the con(s), in my opinion. Nevertheless, this is a problem that concerns me and I was wondering if any of sympatholytic medications typically prescribed for ADHD or a beta blocker can help to mitigate harmful side-effects, especially the psychomotor agitation I mentioned.

I have Klonopin that I've been prescribed but I dislike taking benzodiazepines because I think they dumb me down; plus, I wish to be careful with Klonopin. I happen to have some leftover Propranolol (20mg) and so I took a dose along with my Adderall yesterday. And it really helped! (I think.) So I was wondering how Propranolol compares to medications prescribed for ADHD - Guanfacine and Clonidine. Can or do they help with anxiety?
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Old 01-08-12, 02:37 PM
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Re: Clonidine | Guanfacine | Propranolol

I was given propranolol for my anxiety, and found it to be, by far, the most effective thing I tried. No side effects, no sedating effects, no negatives for me what so ever.
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Old 01-09-12, 09:12 PM
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Re: Clonidine | Guanfacine | Propranolol

So I heard that propranol can be sedating? And cause weight gain? Is this for physical anxiety?
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Old 01-09-12, 09:25 PM
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Re: Clonidine | Guanfacine | Propranolol

Hmm. I do not find propranolol to be sedating. When it was prescribed to me for anxiety I was taking it 3 times a day, but only for a month. I didn't gain weight during that time. I do believe that it is for physical anxiety, not so much mental/emotional anxiety. At one point when I was in the hospital I wasn't given my dose because my blood pressure was "too low". I hope that taking propranolol regularly doesn't cause hypertension...
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Old 01-09-12, 09:38 PM
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Re: Clonidine | Guanfacine | Propranolol

I take clonidine (recently approved for ADHD in an extended-release form as Kapvay).

I have not found it to help with anxiety, per se. It does help me significantly with physical restlessness, though, as well as with a tic-like/OCD-family compulsive behavior. I don't find it sedating.

I'm not sure what it would or wouldn't do to combat stimulant-induced psychomotor agitation as opposed to "endogenous" restlessness.

It's been prescribed (off-label until recently) for years to kids (and now adults) with ADHD who have
- problems with aggression/severe impulsivity/hyperactivity,
- comorbid tic disorders (e.g. Tourette's), and
- problems falling sleep.

It's also used as an antihypertensive, so it would be unlikely to raise your blood pressure (unless you stopped taking it suddenly).

I know less about guanfacine and nothing about propanolol.
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Old 01-09-12, 09:53 PM
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Re: Clonidine | Guanfacine | Propranolol

Thanks for the info. My nervous/anxious habit I think lies somewhere on or near the OCD spectrum. I believe they consider it to be an impulse-control disorder? Skin-picking. :X I was just reading up on psychomotor agitation, and I'm not so sure it fits after all. I don't find myself pacing or wringing my hands or what-have-you.
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Old 01-09-12, 10:01 PM
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Re: Clonidine | Guanfacine | Propranolol

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Originally Posted by known_guy View Post
Thanks for the info. My nervous/anxious habit I think lies somewhere on or near the OCD spectrum. I believe they consider it to be an impulse-control disorder? Skin-picking. :X I was just reading up on psychomotor agitation, and I'm not so sure it fits after all. I don't find myself pacing or wringing my hands or what-have-you.
Skin-picking wasn't formally in the DSM before, but it looks like it'll get added this time around.

Like hair-pulling, it looks like they're planning to place it with "OCD spectrum" disorders (a change from before, where hair-pulling was grouped with "impulse-control" disorders like kleptomania, etc.).

But my best read of things is that there's a lot of uncertainty about compulsive behavior vs. impulse-control issues vs. addictions, etc. Lots of mushy unclear areas.

Anyway, I found clonidine somewhat helpful for hair pulling/skin picking. But with a recent change in other meds, may have lost some ground there. Ask me again in a month or two...
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Old 01-10-12, 06:27 PM
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Re: Clonidine | Guanfacine | Propranolol

I seem to get stuck and cannot focus at these periods I worry about why I cannot focus ? Is that worrying because ssris make everything worse
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Old 01-10-12, 06:52 PM
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Re: Clonidine | Guanfacine | Propranolol

Quote:
Originally Posted by hollywood View Post
So I heard that propranol can be sedating? And cause weight gain? Is this for physical anxiety?
It wasn't sedating at all, for me, just calming, nor did I have any weight gain issues.

It can work for physical or mental anxiety, though the mechanism is purely physical. Basically, it reduces the physical symptoms of anxiety - helps keep your heart rate normal, blood pressure steady, etc. This, in turn, helps keep your mind calm, because it's not being bombarded with fight or flight messages from the body.

Anxiety is not all about pacing or wringing your hands. It can have really subtle effects, like skin-picking, etc. Read up a little bit on the central nervous system, the parasympathetic and sympathetic reactions, and you'll see how calming the physical symptoms can have a positive effect on the mental ones.
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Old 01-10-12, 07:14 PM
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Re: Clonidine | Guanfacine | Propranolol

I suspect my anxiety comes with the onset of physical symptoms and cascaded from that point
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Old 01-11-12, 04:56 PM
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Re: Clonidine | Guanfacine | Propranolol

Second day trying Propranolol, this time without stimulant medications. By golly...I swear this stuff really helps! I really don't think there's a placebo effect going on. It's definitely subtle in effects, but in a positive way. Benzodiazepines like Ativan/Klonopin/Xanax make me feel stupid. Inderal doesn't do that - I remain 100% lucid.
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Old 01-11-12, 08:36 PM
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Re: Clonidine | Guanfacine | Propranolol

I don't fair well with benzos either.
I found clonidine to be incredibly effective for hyperactive/nervous symptoms, unfortunately it dropped my bp too much.
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Old 01-11-12, 10:53 PM
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Re: Clonidine | Guanfacine | Propranolol

Huh, lucid? WTF? Anyways maybe I will try propranolol !
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Old 01-11-12, 11:28 PM
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Re: Clonidine | Guanfacine | Propranolol

Lucid? Uh, yes, lucid.

lu·cid/ˈlo͞osid/

Adjective:
  • Expressed clearly; easy to understand: "a clear and lucid style".
  • Showing ability to think clearly, esp. in the intervals between periods of confusion or insanity.
There have been times when other medications like benzodiazepines made me feel blunted. In contrast, the Inderal doesn't seem to impair cognitive functioning. BPD was so named to describe patients who seemed to be on the borderline between neurosis and psychosis. So I believe the word is an appropriate one to use in this context - in my case in particular, rather.
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Old 01-11-12, 11:38 PM
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Re: Clonidine | Guanfacine | Propranolol

The one and only time my doctors tried me on Xanax, it knocked me out for 8 hours, I woke up feeling like utter hell, and I had a medication 'hang over' that left me useless for another 24 hours. I was groggy, couldn't think straight, couldn't drive, could barely talk, and felt like I'd been kicked down a hill in a barrel filled with rocks. And that was on a small dose, with no other medications.
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