Simple way to increase effectiveness w/out uping the dosage

[abre los ojos]

Add L-Tyronsine. This seems to be common knowledge, but I found some clinical studies which back up this notion scientifically.

Catecholamine metabolism in the attention deficit disorder: implications for the use of amino acid precursor therapy.

McConnell H.

The use of catecholamine precursors and agonists in the attention deficit disorder and various biochemical studies have implicated deficient catecholamine metabolism in the pathogenesis of this illness. The amino acid L-tyrosine, a catecholamine precursor, is capable of augmenting central dopamine norepinephrine. Study of its use in the treatment of the attention deficit disorder as a safer alternative to stimulant therapy is thus warranted.

Plasma amino acids in attention deficit disorder.

Bornstein RA, Baker GB, Carroll A, King G, Wong JT, Douglass AB.

Ohio State University, Columbus 43210.

This study examines plasma amino acids in a group of 28 patients meeting DSM-III criteria for attention deficit disorder (ADD) and 20 control subjects. Compared with controls, the ADD subjects had significantly lower levels of phenylalanine, tyrosine, tryptophan, histidine, and isoleucine. These data suggest a general deficit in amino acid transport, absorption, or both.


Exogenous tyrosine potentiates the methylphenidate-induced increase in extracellular dopamine in the nucleus accumbens: a microdialysis study.

Woods SK, Meyer JS.

Psychology Department, University of Massachusetts, Amherst 01003.

Previous work has shown that the synthesis and release of dopamine may, under certain conditions, be influenced by an increase in the availability of its amino acid precursor, tyrosine. To examine whether exogenous tyrosine could potentiate the methylphenidate-induced increase in extracellular dopamine, male rats were implanted with microdialysis probes aimed at the right nucleus accumbens. Samples were collected from awake animals beginning 22 h after surgery. A repeated measures design was used involving the continuous collection of 20-min samples for a 4-h period once a day for 3 consecutive days. On a given day, an animal was infused with methylphenidate, tyrosine, or methylphenidate plus tyrosine. Periods of infusion with the active compounds were preceded and followed by baseline conditions, and treatments were counterbalanced to control for possible order effects. Methylphenidate plus tyrosine significantly increased extracellular levels of dopamine in comparison to drug alone. This effect was long-lasting, persisting into the post-treatment sampling period and peaking 40 min after the peak induced by methylphenidate alone. Tyrosine alone induced a small but significant increase in extracellular dopamine in the absence of any treatment to accelerate the firing of dopamine cells. These findings may have implications for the treatment of attention deficit hyperactivity disorder.

[livinginchaos]

cool. thanks. i'm going to look more into it