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  #1  
Old 01-31-18, 12:15 PM
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Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

I always read and hear how Dopamine is the cause of adhd(lack of, too much of etc) I also do not quite understand what dopamine agonests (sp) are and what they do and how it relates to adhd and the treatments for adhd. If this is the case, is it scientifically accurate and true? Like, is it more of a theory without much proof or is it a definite?
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Old 01-31-18, 12:50 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

It’s a theory.

https://en.wikipedia.org/wiki/Agonist


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Old 01-31-18, 01:40 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Research shows that five areas of the brain are smaller in people diagnosed
adhd and that plays a part in how well the brain works.

There has also been research that shows the dura (the lining of the brain where
the synapses that carry messages is located) is thinner in people with adhd,
and therefore less capable of conveying those messages.

Apparently the dopamine receptors are located in that dura layer.
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Old 01-31-18, 05:09 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Quote:
Originally Posted by aeon View Post
It’s a theory.

https://en.wikipedia.org/wiki/Agonist


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To be fair, I scanned the article and it was about agonists but I have seen here repeatedly where people say their adhd or their meds are working on dopamine, or depleting dopamine- or targeting dopamine. Sometimes Ive read people who just up and decide that they should stop their antidepressants because its affecting their dopamine. How they hell do they know that?
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Old 01-31-18, 07:50 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Quote:
Originally Posted by sarahsweets View Post
To be fair, I scanned the article and it was about agonists but I have seen here repeatedly where people say their adhd or their meds are working on dopamine, or depleting dopamine- or targeting dopamine. Sometimes Ive read people who just up and decide that they should stop their antidepressants because its affecting their dopamine. How they hell do they know that?
Few antidepressants, other than novel ones that have been discontinued or exist only in limited markets, work directly on dopamine in a substantial way, and for those that don’t, there may be effect as it regards overall sense of well-being, but in general, it isn’t because the dopamine function is being messed with.

As it regards saying ADHD is caused by a problem with dopamine, it is a quickly adopted idea based on a shred of would-be evidence.

In this way, it is similar to the idea of depression being caused by a neurotransmitter imbalance. It is often said this is the problem, and meds help to balance them. The idea is just that - a theory, and nothing has been proven one way or the other. For that matter, perhaps neurotransmitter imbalance is a result of depression, not a cause. No one knows for sure.

That said, I think there are multiple causes of depression, but we don’t yet understand or appreciate the number of avenues to what we eventually call a single disorder.

I think much is the same for ADHD...it is one diagnosis (with subtypes, like major depressive disorder) with many potential ways to reach that diagnosis.

In both cases, there are likely a multitude of factors contributing to the end result, but in the common vernacular, the idea of neurotransmitter problems has taken over the current day discussion and shorthand.

I think it is intellectually lazy* to say such things, if not scientifically irresponsible, but I can appreciate that no one outside of the discipline of neurophysiology (among potentially many others) has the knowledge, much less the time, to give these ideas the consideration and expression they merit.

So slang rules the roost. Unfortunately, it is often taken as gospel.


Cheers,
Ian

* I’m intellectually lazy, so it isn’t a case of the kettle calling the pot black.
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Old 02-01-18, 09:12 AM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

There are multiple genes at work when it comes to ADHD, some of which are involved in Dopamine in some way (they produce it, or get triggered by it or get shut down by it etc.)

I think that's what they know; any more specific is just guesswork at this point.

from wikipedia:
A dopamine receptor agonist is a compound that activates dopamine receptors. (=a chemical that acts as dopamine)

Amphetamines (Adderall) and methylphenidate (Ritalin) are indirect agonists (they increase dopamine production and/or inhibit the reuptake of dopamine (= shut down the dopamine vacuum cleaners so there is more active dopamine))

afaik there is no way to directly get actual dopamine into the brain (in a safe manner). Same goes for Serotonin, don't eat banana's for Serotonin, it doesn't pass the blood-brain barrier. A classic anti-depressant would be an SSRI (selective serotonin reuptake inhibitor), which doesn't produce Serotonin, but it prevents the reuptake (garbage collection) of extra serotonin in the synaptic cleft.
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Old 02-01-18, 05:36 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Quote:
Originally Posted by sarahsweets View Post
I always read and hear how Dopamine is the cause of adhd(lack of, too much of etc) I also do not quite understand what dopamine agonests (sp) are and what they do and how it relates to adhd and the treatments for adhd. If this is the case, is it scientifically accurate and true? Like, is it more of a theory without much proof or is it a definite?

ADHD is not due to an over abundance of dopamine.

I think dopamine deficiency associated with ADHD is the effect of multiple causes. (specifics depend on the individual circumstances and individual temperament)

So, no, I do not think ADHD causation is strictly related to dopamine deficiency.





M
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Old 02-02-18, 08:44 AM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

The short answer is no, saying that ADHD is purely due to dopamine dysfunction is a vast simplification. Most of the drugs approved for ADHD do target dopamine and its close cousin norepinephrine (noradrenaline), but there are other systems that regulate attention and arousal (acetylcholine, which is what nicotine targets being one).

It's kind of like saying that depression is due to a lack of serotonin.
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Old 02-03-18, 01:12 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Take dexedrine and we become motivated to do anything we wish.
Wasn't it used as the motivation (dull!) for house wives to do the cleaning.
What would we expect if we were to do something that is not motivational ?
To be unmotivated.
What would we expect if we were to do something that is motivational ?
To be motivated.
But what if we are expected to perform a task which we think but which we aren't actually motivated towards ?
Confused, reach for medication and hope that it works - and what if it doesn't ?
Well the workplace becomes an act of profound pain as one really cannot pay attention.

-*-

Anybody with insight into the dreary nature of their 'to do' list in this current society should be able to understand why they can't pay attention.
It's not human to be able to joyously throw oneself into anything that is dull.
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Old 02-03-18, 02:18 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

I thought it was a tiny, but serious, gap in a certain part of the brain.
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Old 02-03-18, 08:30 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

There is no known cause for the symptoms that make up the disorder adhd
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Old 02-04-18, 02:30 AM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Quote:
Originally Posted by SB_UK View Post
Take dexedrine and we become motivated to do anything we wish.
Wasn't it used as the motivation (dull!) for house wives to do the cleaning.
What would we expect if we were to do something that is not motivational ?
To be unmotivated.
What would we expect if we were to do something that is motivational ?
To be motivated.
But what if we are expected to perform a task which we think but which we aren't actually motivated towards ?
Confused, reach for medication and hope that it works - and what if it doesn't ?
Well the workplace becomes an act of profound pain as one really cannot pay attention.

-*-

Anybody with insight into the dreary nature of their 'to do' list in this current society should be able to understand why they can't pay attention.
It's not human to be able to joyously throw oneself into anything that is dull.

Nice to think about your perspectives.

It is “human to be able to joyously throw oneself into anything that is” fun. (unless the humans’ SEEKING system, CARE system and PLAY system are under active.)

What is the difference between Hypoactivity and Underactivity?

Example?

low blood sugar, verses, a pancreas that does not produce enough insulin?







M
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Last edited by mildadhd; 02-04-18 at 02:53 AM..
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Old 02-04-18, 05:36 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Short answer : "No"

Slightly longer answer : "No it's not."


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Old 02-04-18, 07:41 PM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Dopaminergic pathways are definitely involved, but dopaminergic pathways are definitely not the only factors involved.





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Old 02-05-18, 06:52 AM
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Re: Is ADHD strictly related to the production of/ lack of/ too much of Dopamine?

Adenosine is another neurotransmitter that affects dopamine. If you change the number of adenosine receptors through coffee consumption and then don’t drink enough coffee to counteract all the extra adenosine due to coffee consumption it can create a state where it’s harder for dopamine to do its job.

Here’s a video that explains it very simply in the first 2.5 minutes

https://youtu.be/foLf5Bi9qXs
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