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Adderall (four amphetamine salts)

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  #1  
Old 10-26-05, 01:25 PM
fixmeplease fixmeplease is offline
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Adderall and beta blockers

I found some sites listing beta blockers as a negative interaction with Adderall/amphetamines. The drug/drug interaction checker on Drugstore.com mentions no interaction and neither does WebMD (well it says to tell your doctor about high blood pressure medications which includes beta blockers).

Anyone have information about this? Am I misunderstanding what I'm reading or is this a very rare interaction?

I see it written on multiple sites that "Adrenergic blockers are inhibited by amphetamines." and "Amphetamines may antagonize the hypotensive effects of antihypertensives. "
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Drug Category: Cardiovascular agents
..."Treating with beta-blocker to control heart rate will leave an unopposed alpha activity that causes vasoconstriction..."

http://www.emedicine.com/EMERG/topic23.htm#section~medication

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Cocaine or Amphetamine Toxicity; other hyperadrenergic syndromes
Drugs to Avoid (or Use With Caution)
"There are no data from controlled studies. avoid Beta blockers - may cause paradoxical hypertension or coronary spasm from unopposed alpha-adrenergic activity; caution with Labetalol."

https://labs-sec.uhs-sa.com/clinical_ext/RefDocs/Emergent_HTN.html


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"Beta-adrenergic blocking agents...Use of amphetamines with beta-blocking agents may increase the chance of high blood pressure and heart problems"

http://www.drugs.com/cons/Adderall.html

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"
The use of Ŗ-adrenergic antagonists is somewhat controversial because of the potential for an exaggerated alpha-adrenergic stimulation response. Instead, treatment of hypertension from psychostimulant overdose with alpha-adrenergic, mixed alpha- and Ŗ-adrenergic antagonists, or nonadrenergic agents is recommended by some authors."

http://www.medscape.com/viewarticle/405795_3

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"Cardiac arrhythmias can be managed in the usual manner, remembering that use of b-blockers can lead to unopposed alpha-adrenergic stimulation and worsening of the patientís condition."

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"Beta-adrenergic blocking agents, including ophthalmics (concurrent use with amphetamines may result in unopposed alpha-adrenergic activity with a risk of hypertension and excessive bradycardia and possible heart block; risk may be less with labetalol because of its alpha-blocking activity)"

http://www.drugs.com/MMX/Amphetamines.html

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http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a601234.html
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Old 10-26-05, 01:50 PM
dbr2 dbr2 is offline
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I have taken Adderall w/ Inderal. I now take it w/ metoprolol. Both are beta-blockers. My Dr knows about it. I do not know if any other betablockers might present different issues. I suggest you ask your Dr or pharmacist.

Best Regards,

DBR
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