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Old 11-10-07, 09:48 PM
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Prozac a stimulant?

While Prozac is not technically a stimulant, I've heard from one of my college professors that Prozac has mild stimulating properties? Does it affect dopamine or does he mean stimulation in depression maybe? I would ask but I had the class over a year ago.
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Old 11-10-07, 10:04 PM
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Re: Prozac a stimulant?

Yes, it is mildly stimulating. In higher doses (or over time) it begins to sedate.

Yes, it affects dopamine after a while of taking it (indirectly). (Most psychoactive drugs are 'dirty' that way.)
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Old 11-10-07, 10:36 PM
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Re: Prozac a stimulant?

I've heard from a pdoc (not mine) that Zoloft also affects several neurotransmitters and I've seen that info on this thread. He also said that Lexapro only affects serotonin. I find it weird since they are called SSRIs and work on more than just the S...
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Old 11-11-07, 12:51 AM
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Re: Prozac a stimulant?

Zoloft affects dopamine to a much higher degree than other SSRI's. Still, this effect is rather minimal compared to it's effects on serotonin reuptake. The least dirty (well, as far as those common in this class) are Celexa and the related Lexapro, as has been already stated.

The human body and brain works on a complex system, and these drugs produce effects by exploiting certain properties of this system. Creating a drug that does exactly one thing is not a direct and obvious. It's similar to creating exploits for computer programs. The program is already there, and one has to take advantage of the design of the program in order to achieve the desired effect.

Drugs are often classified based upon their intended purpose. Bupropion (Wellbutrin) is not considered a stimulant class drug, though it is most certainly a stimulant in it's effects. Since Zoloft's dopamine actions are 100 times less potent than it's serotonin effects, it's called an SSRI because the dopamine action isn't that significant.

You might be interested in this website:
http://www.preskorn.com/columns/0005.html
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Old 11-11-07, 03:30 PM
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Re: Prozac a stimulant?

And in accordance to wikipedia (should this be the case), Paroxetine (generic Paxil/Pexeva) is the most selective for serotonin reuptake.
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