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Daytrana (methylphenidate)

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Old 01-06-08, 04:38 AM
E=mc2 E=mc2 is offline
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Adderall to Daytrana?

Are there any teens or adults out there who have gone from Adderall to Daytrana patches due to the harsh side effects and rebound brought about by the Adderall?
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Old 01-15-08, 09:51 PM
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Re: Adderall to Daytrana?

Beware of more rapid absorption after you've been on Daytrana for 6 weeks or so and/or if you seem to have contact sensitivity. My daughter switched from 36 mg Concerta to 30 mg Daytrana and from what I figure, she was actually getting up to 80-90 mg because of these issues. She spent most of last school year as a moody, zoned-out, irrational mess. I think the dose was too high AND she's sensitive to mph.

http://dailymed.nlm.nih.gov/dailymed...5&type=display

"Daytrana™ mean peak d-MPH concentrations were approximately 1.9-fold higher than the highest observed concentrations after a once-daily oral methylphenidate formulation over a period of 7.5 to 10.5 hours, when Tmax typically occurs. These higher concentrations were observed for all children 6 - 12 years of age, both overall and when grouped by age. The Daytrana™ peak concentrations on chronic dosing were also higher than Cmaxs seen with Daytrana™ after single dosing, or 4 days of multiple dosing. With single doses of Daytrana™, peak concentrations were comparable to Cmaxs from single doses of the once daily oral MPH formulation. The observed exposures with Daytrana™ could not be explained by drug accumulation predicted from observed single dose pharmacokinetics and there was no evidence that clearance or rate of elimination changed between single and repeat dosing. Neither were they explainable by differences in dosing patterns between treatments, age, race, or gender. This suggests that transdermal absorption of methylphenidate may increase with chronic therapy with the methylphenidate transdermal system."

Be especially careful if you seem allergic or sensitive to the patch (rash that lasts longer than a day or so after removal):

"When Daytrana™ is applied to inflamed skin both the rate and extent of absorption are increased as compared with intact skin. When applied to inflamed skin, lag time is no greater than 1 hour, Tmax is 4 hours, and both Cmax and AUC are approximately 3-fold higher."

and

"Use of Daytrana™ may lead to contact sensitization. Daytrana™ should be discontinued if contact sensitization is suspected. Erythema is commonly seen with use of Daytrana™ and is not by itself an indication of sensitization. However, sensitization should be suspected if erythema is accompanied by evidence of a more intense local reaction (edema, papules, vesicles) that does not significantly improve within 48 hours or spreads beyond the patch site. Diagnosis of allergic contact dermatitis should be corroborated by appropriate diagnostic testing.


"Patients sensitized from use of Daytrana™, as evidenced by development of an allergic contact dermatitis, may develop systemic sensitization or other systemic reactions if methylphenidate-containing products are taken via other routes, e.g., orally. Manifestations of systemic sensitization may include a flare-up of previous dermatitis or of prior positive patch-test sites, or generalized skin eruptions in previously unaffected skin. Other systemic reactions may include headache, fever, malaise, arthralgia, diarrhea, or vomiting.

"Patients who develop contact sensitization to Daytrana™ and require oral treatment with methylphenidate should be initiated on oral medication under close medical supervision. It is possible that some patients sensitized to methylphenidate by exposure to Daytrana™ may not be able to take methylphenidate in any form."

Read through the entire information sheet.
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Old 02-03-08, 07:47 PM
E=mc2 E=mc2 is offline
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Re: Adderall to Daytrana?

Thanks so much.
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