Histadelia? Fantasy Internet Illness?

[Hobbledehoy]

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http://www.diagnose-me.com/cond/C447056.html

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Histadelia (Histamine High)

Histadelia, more common in males, is characterized by elevated
blood levels of histamine. It is estimated that 15-20% of
schizophrenics are probably histadelic. The treatment of
histadelia requires great patience because six to ten weeks
are often needed before the beginning of significant
improvement. The treatment usually takes twelve months to
complete. To find out more about this see Mental Illness: The
Nutrition Connection, a book by Carl Pfeiffer. The prognosis
is good if the histadelic patient cooperates with treatment
and works to give up detrimental addictions.

*** Signs, symptoms & indicators of Histadelia
(Histamine High):

* Allergy

* Excess mucous: Histamine can cause additional mucus
production.

* Good tolerance of cold

* Poor tolerance of heat

* Unexplained nausea

* Poor pain tolerance

* Excess/abundant saliva in mouth

* Hyperactivity: Histamine speeds up metabolism producing a
tendency towards hyperactivity.

* Frequent colds/flus

* Phobias

* Being highly motivated: Those with elevated histamine
(histadelics) tend to work compulsively.

* A hard-driving personality: Histadelics tend to work
compulsively.

* Good creativity/imagination: Histadelics are often
highly creative.

* Strong sexual desire

* Joint pain/swelling/stiffness

* Excess perspiration

* Warm skin

*** Conditions that suggest Histadelia (Histamine High):

* Allergy: Allergic Rhinitis / Hay Fever

* Depression: Histadelics are often chronically and
suicidally depressed.

* Obsessive-Compulsive Disorder (OCD): Histadelics are often
prone to obsessions, compulsions, and addictions.

* Addictions / Addictive Tendencies: Nutritional treatment
for drug and alcohol users will depend on the results of a
test for blood histamine levels. In one series of such
analysis, all users proved to have high histamine levels,
leading the scientist to conclude that this abnormality -
with its impact on brain function - is a major force in
creating addiction. [Nutrition Guide for the Prevention
and Cure of Common Ailments and Diseases, Carlton
Fredericks, PhD. p.58]

* Headaches

* Insomnia: The overarousal seen in histadelia may
contribute to insomnia.

* Muscle Pains (Myalgia)

* History of unexplained nausea

* Slender fingers / toes: Histadelics often have long
fingers and toes.

*** Recommendations for Histadelia (Histamine High):

* Methionine: Methionine supplements lower blood levels of
histamine by increasing histamine breakdown.

* Calcium

* Copper: Copper levels may be low to normal in patients
with histadelia. Copper is part of the enzyme histaminase,
which is involved in the metabolism of histamine.

* Magnesium

* Manganese

* Vitamin B6 (Pyridoxine)

* Vitamin C (Ascorbic Acid)

* Vegetarian/Vegan Diet Nutritionists recommend a low-protein,
high
complex carbohydrate diet. Histidine, which is more common
in animal
proteins, should be avoided as it can be converted into
histamine.

*** Not recommended

* Vitamin Folic Acid: Histadelics should avoid supplemental
folic acid as it can produce excess histamine. In fact,
anti-folate drugs may be required. Folic acid increases
depression in histadelic patients and a trial of folic
acid could be used to distinguish between histapenics and
histadelics. In extreme cases, folic acid in food or in
multivitamins is enough to produce the adverse effects.

*** Lab Tests

* Copper Levels: Testing serum or hair copper levels is
usually adequate for evaluating copper status when low
levels of copper are suspected and hair contamination with
copper can be ruled out. When in doubt, it would be better
to use more accurate tests such as the 24 hour urine copper
or serum ceruloplasmin.

* Histamine Levels

* Folic Acid Levels: Under certain conditions, such as
anticipated or actual pregnancy, a simple lab test for
serum folate levels is advisable. If the test results show
low levels, supplementation should be considered to prevent
potential birth defects.

* Zinc Levels

* Manganese Levels

*** Glossary

* Histamine: A chemical in the body tissues, produced by the
breakdown of histidine. It is released in allergic
reactions and causes widening of capillaries, decreased
blood pressure, increased release of gastric juice, fluid
leakage forming itchy skin and hives, and tightening of
smooth muscles of the bronchial tube and uterus.

* Metabolism: The chemical processes of living cells in which
energy is produced in order to replace and repair tissues
and maintain a healthy body. Responsible for the production
of energy, biosynthesis of important substances, and
degradation of various compounds.

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Histadelia represents the chemical antithesis of histapenia in
that it involves elevated blood histamine. This condition
(involving about 20 percent of schizophrenics) is
characterized by delusions, severe depression,
obsessive/compulsive behavior, and blank-mindedness, and often
results in a diagnosis of schizo-affective disorder. Treatment
revolves around anti-folates such as calcium, methionine, and
the prescription drug Dilantin® along with augmenting
nutrients. Histadelia treatment requires great patience,
because six to ten weeks are often needed before the beginning
of significant improvement. The treatment usually takes twelve
months to complete.

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Histadelic depressives have a particular imbalanced amino-acid
cycle, which results in low levels of serotonin and elevated
histamine. Histadelics often exhibit obsessive-compulsive
tendencies, perfectionism, seasonal allergies, easy tears,
high libido, and headaches. They have addictive tendencies
with a high incidence of alcoholism, drug abuse, anorexia, and
bulimia. They often are diagnosed with seasonal affective
disorder which is most serious during Fall and Winter. The
decisive chemical test for this condition is whole blood
histamine. We treat histadelia with a biochemical one-two
punch in which (1) calcium is given to release excess
histamine from tissues into the bloodstream, and (2)
methionine (SAMe) is provided to add a methy group to blood
histamine and hasten its exit from the body. With good
compliance, improvement is usually noted in 4-8 weeks with
about 3-6 months needed to correct this chemical imbalance.

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Armed with the proper nutrients, I smuggled them back in to
the last hospital I was in, and took them on the sly while
mouthing my medication, and spitting it down a toilet.

After just three weeks of taking my supplements, I was doing
so much better that I was given a full medical discharge, with
the doctors scratching their heads, wondering which of their
drugs had been helping me, but none of them had been -- I was
spitting them all down the toilet where the toxic substances
belonged. That was 23 years ago.

Pfeiffer discovered that food and inhalant allergies caused me
to have an overproduction of histamine which is peripherally
stored in basophils of the blood and the tissue mast cells.
Basophil counts greater than 50 cells/cu mm and histamine
levels greater than 70 ng/ml (10 mcg%) are considered
diagnostic for histadelia. The average histamine for males was
111 mg/ml and females 107 mg/ml in a study reported in 1975.
My histamine levels were up to 126. This is significantly
different from normals: 42 and 46 mg/ml for males and females
respectively. Histadelia causes suicidal depression, paranoia,
and obsessive thinking.

The amino acid methionine (SAMe) detoxifies histamine by
methylating the ring structure forming N-methylhistamine.
Calcium, taken in the form of calcium salts reduces the
release of the bodies store of histamine. Zinc and
manganese aid the calcium-methionine program and provide
sufficient relief.

Pfeiffer also discovered that I had very high aluminum levels,
and copper levels, as well as overproduction of an enzyme
called kryptopyrolle. This enzyme robbed me of zinc, a copper
antagonist that I needed to eliminate excess copper which was
having an excitory effect on the brain as an electrolyte,
contributing to my difficulty concentrating, to thought
disorder as well as to my severe depression.

In essence: high copper levels were shorting out my brain,
interfering with neural firing. Zinc, Manganese, and vitamin C
all help to lower a copper burden. The amino acids l-tyrosine,
and l-tryptophan boost norepeniphrine and dopamine levels
respectively, also helping to alleviate depression.

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Histadelia: This is a disorder, prominent in males, of too
much histamine in the blood. Estimated to affect 15-20% of
patients classified as "schizophrenic."

Symptoms include hyperactivity, compulsions, obsessions, inner
tensions, blank mind episodes, phobias, chronic depression,
and strong suicidal tendencies.

Physical signs can include little tolerance for pain, rapid
metabolism, lean build, profuse sweating, seasonal allergies,
and frequent colds.

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Histadelia - In the early years of this century, at the height
of his career, Nijinski, the much-acclaimed Russian dancer,
was diagnosed as incurably insane. Nijinsky may have been
histadelic. One of the first indications of his illness
occurred when Nijinsky, who had previously been especially
caring and gentle, pushed his wife and infant child downstairs
and afterwards seemed confused about the incident. He began
refusing animal food (actually, probably a beneficial choice,
if he was histadelic), and sometimes would not eat at all for
long periods of time. He became obsessed with recurrent
visions of dead soldiers, and prone to violence, especially
when separated from the mental institute. Nijinsky never
recovered and never danced again, although his wife found that
he did not seem to have forgotten any move of any dance he
ever performed.

Histadelia is characterized by elevated blood levels of
histamine. 15-20% of schizophrenics are probably histadelic.
Histadelics tend to work compulsively and are often highly
creative. On the other hand, they are often chronically and
suicidally depressed and prey to obsessions, compulsions, and
addictions.

Typical treatment includes such nutrients as calcium,
magnesium, B6, C, zinc, manganese, and methionine (SAMe),
and limitation of intake of folic acid and histidine (common
in animal proteins). If the histadelic cooperates with
treatment and works to give up detrimental addictions, the
prognosis is good.

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On the physical front, nutrient deficiencies, glucose
intolerance and allergy are extremely common in those
suffering from depression. One major cause is an excess of the
neurotransmitter hormone histamine - a condition known as
histadelia. Dr Carl Pfeiffer asks: "Do you sneeze in bright
sunlight? Cry, salivate and feel nauseous easily? Hear your
pulse in your head on the pillow at night? Have frequent
backaches, stomach and muscle cramps? Do you have regular
headaches and seasonal allergies? Have abnormal fears,
compulsions and rituals? Do you burn up food rapidly and
sometimes entertain suicidal thoughts? ...If a majority of
these apply to you, you may benefit from a low-protein, high
complex carbohydrate diet (fruits and vegetables), 500mg of
calcium, am and pm, 500mg methionine am and pm and a basic
supplement program. Avoid supplements containing folic acid as
these can raise histamine levels."

Some of our most loved stars, such as Marilyn Monroe and Judy
Garland, were likely histadelics. Drawing from over 30 years'
experience, Pfeiffer estimates that at least 20% of
schizophrenics are histadelics and these are often the problem
patients in psychiatric hospitals, since they do not respond
to the usual drug treatments, electroshock or insulin coma
'therapy'.

Blood histamine levels can be analysed and often, the
compulsive obsessions, blank mind, easy crying and confusion
may highlight an underlying chemical addiction to cane sugar,
alcohol or drugs. Histadelics experience high saliva discharge
and rarely have cavities. Often they are seen wiping saliva
from the corners of their mouth. Excess histamine presents
rapid oxidation in their body, and their high metabolic rate
and subsequent attractive body shape are sometimes potential
indicators for the underlying condition. Marilyn Monroe was
often heard to remark to photographers: "You always take
pictures of my body, but my most perfect feature is my teeth -
I have no cavities."

A high sex drive characterises the histadelic, who achieves
orgasm and sustains it easily. Drug addicts and alcoholics
also tend to be histadelic. Heroin and methadone for instance
are both powerful histamine-releasing agents. A severe
insomnia also characterises the condition, and sufferers often
use heavy doses of sedatives in order to get to sleep. The
sedatives themselves often become an addiction problem,
further compounding the plight suffered by those with
depression.

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A common contributory cause of depression is an excess of
histamine, known as histadelia, which is mostly inherited.
Histamine speeds up metabolism but also causes allergic
reactions, increased mucus and saliva production and a
tendency to hyperactivity, compulsive behaviour and
depression. About 20% of those labelled schizophrenic and most
depressed people are histadelic. Some of the signs of this
tendency are insomnia, frequent headaches, body aches,
salivation and nausea.

To find out more about this consult a nutritionist or
see Mental Illness: The Nutrition Connection, a book by
Carl Pfeiffer.

Ways to overcome histadelia: Nutritionists recommend a
low-protein, high complex carbohydrate diet. That means
replacing refined carbohydrates in things like chocolate,
snacks and white bread with unrefined carbohydrates in
wholefoods and grains, fruit and vegetables, including
potatoes. Histadelics should avoid folic acid, as it can
produce excess histamine. Folic acid comes in many
multivitamin pills, and also certain vegetables such as
spinach, lettuce and broccoli. It is also found in liver
and kidneys.

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I came across this information when I was researching what may be wrong with me. It may have be some other form of ADD, it may mimic ADD, when ADD and severe allergies intertwine, or it may not be real.

But I can tell you that I fall into most to all of the categories. I even have weirdo long toes. When I first started the SSRI, I thought that it didn't work. But the first thing that I noticed was a decreased tolerance for cold.

When my anxiety was at it's worst, I would go outside in 45 F weather in my 40 degree sleeping bag just to get a peace of mind.

The second thing I noticed was an increase in pain tolerance! It just happened that the first thing I poked was my penis, which sent me into panic that the meds were shriveling me up, but I began pinching all over and finding out that I could take 10x more pain.

My sex drive is lowering, but that's a good thing. Because you can't teach a class while focusing on keeping it down. You just can't.

I don't know if this information is true or not, but I do know that there is something to it. I'm also aware that most medical professionals don't take it seriously.

But here it is for you to decide.

[WarPhalange]

Worth getting checked out. Seems like some simple blood/urine tests, right? Much easier than having to get a subjective diagnosis from a pdoc. Especially if they think people "grow out" of AD(H)D. Even if the docs don't think this is real, if you see all the lab results in sync with what is written in your post, you can do treatment yourself. Seems like you can do a lot with just OTC stuff.

[Contrapunctus]

"Histadelia" sounds like a bunch of nonsense; it is not accepted in mainstream medicine...

[Hobbledehoy]

Originally Posted by Contrapunctus

"Histadelia" sounds like a bunch of nonsense; it is not accepted in mainstream medicine...

What does "not accepted in mainstream medicine" mean? Are you saying that we've accomplished all things medical?

[Contrapunctus]

What "not accepted by mainstream medicine" means, is that because there are no peer-reviewed studies supporting the "histadelia" diagnoses, no true medical professional will take any stock in such a notion. The proponents of "histadelia" do not follow the scientific method, and therefore have no credibility.

Histadelia is a diagnoses made through so-called "Orthomolecular" medicine. The American Psychiatric Association made the following statement about this form of medicine:

This review and critique has carefully examined the literature produced by megavitamin proponents and by those who have attempted to replicate their basic and clinical work. It concludes in this regard that the credibility of the megavitamin proponents is low. Their credibility is further diminished by a consistent refusal over the past decade to perform controlled experiments and to report their new results in a scientifically acceptable fashion.

Under these circumstances this Task Force considers the massive publicity which they promulgate via radio, the lay press and popular books, using catch phrases which are really misnomers like "megavitamin therapy" and "orthomolecular treatment," to be deplorable

http://www.quackwatch.org/01Quackery...ics/ortho.html

Of course, there is much to be discovered in Medicine, but these things must be proven in controlled trials, and subject to the review of their peers in the medical field...

[Hobbledehoy]

Originally Posted by Contrapunctus

What "not accepted by mainstream medicine" means, is that because there are no peer-reviewed studies supporting the "histadelia" diagnoses, no true medical professional will take any stock in such a notion. The proponents of "histadelia" do not follow the scientific method, and therefore have no credibility.

Histadelia is a diagnoses made through so-called "Orthomolecular" medicine. The American Psychiatric Association made the following statement about this form of medicine:


http://www.quackwatch.org/01Quackery...ics/ortho.html

Of course, there is much to be discovered in Medicine, but these things must be proven in controlled trials, and subject to the review of their peers in the medical field...

Fair enough. I'm benefiting as it is from SSRI with little side effects. I just found it extremely interesting since I did discover that anti-histamines made a noticeable difference in the anxiety that I was dealing wtih. I would take benadryl and fish oil to reach peace of mind. It was working until things got really bad.

So as I said, it could be a fancy name for ADD with allergies. Allergies, from experince, can exacerbate ADD.

[WarPhalange]

Benadryl makes a lot of people drowsy. If you have anxiety, it might only make you relax enough so that you aren't freaking out all the time, but I don't know if you can claim why it does that.

[Hobbledehoy]

Originally Posted by WarPhalange

Benadryl makes a lot of people drowsy. If you have anxiety, it might only make you relax enough so that you aren't freaking out all the time, but I don't know if you can claim why it does that.

I've taken Zyrtec (also known to cause drowsiness) which increased my anxiety. Different antihistamines have different chemical compounds. And after taking the medicine for awhile, you usually don't get drowsy as much, if any.

http://wiki.answers.com/Q/How_well_d...trin_treat_ADD

This guy was taking a different Zyrtec than me, but I'm sure the anti-histamines affect people differently.

[meadd823]

May be of interest

high/low histamine

Like I said I think there is a link between histamine and ADD especially hyperactivity however there is still some thing not quiet right even with this approach. . . . .but I good find none the less! Thanks

Plus the hyperlink has the additional benefit of saving me a lot of re-typing.

[Hobbledehoy]

Thanks for the read meadd823.

[sloppitty-sue]

Thanks for sharing this, Hobbledehoy. This histadelia describes my ex to a "t." Very, very interesting.

It would thrill me one day if my ex recovered his sanity and if doctors finally could say - with more certainty - what was ailing him. He's one of those abnormally behaving individuals whose ability to function in the world is unpredictable. He had a professional job when I met him, and was an incredibly charming conversationalist. We married and had a child, but things (mainly his grip on reality and his treatment of me - got unbelievably abusive, including physical violence) deteriorated rapidly and our relationship didn't last long.

I later learned that his behavior has always varied from almost normal to severely psychotic and disruptive/violent throughout his life - and he's been dx with all of the severe mental illnesses at one time or another - none of which (including their treatments) ever helped him or his loved ones much.

It's just remarkable how much the typical histadelic sounds like him. He's got UNUSUALLY LONG, THIN toes and fingers too. He's very, very thin and tall - has been anorexic mostly due to chronic nausea and stomach pain. VERY INTOLERANT to pain -- complained of needing MORPHINE when his new shoes gave him blisters! Tears up/cries easily and never has dry mouth. His skin always feels warm, although he does dress in layers.

Hmmm . . . . ???



Sue

[Hobbledehoy]

Originally Posted by sloppitty-sue

Thanks for sharing this, Hobbledehoy. This histadelia describes my ex to a "t." Very, very interesting.

It would thrill me one day if my ex recovered his sanity and if doctors finally could say - with more certainty - what was ailing him. He's one of those abnormally behaving individuals whose ability to function in the world is unpredictable. He had a professional job when I met him, and was an incredibly charming conversationalist. We married and had a child, but things (mainly his grip on reality and his treatment of me - got unbelievably abusive, including physical violence) deteriorated rapidly and our relationship didn't last long.

I later learned that his behavior has always varied from almost normal to severely psychotic and disruptive/violent throughout his life - and he's been dx with all of the severe mental illnesses at one time or another - none of which (including their treatments) ever helped him or his loved ones much.

It's just remarkable how much the typical histadelic sounds like him. He's got UNUSUALLY LONG, THIN toes and fingers too. He's very, very thin and tall - has been anorexic mostly due to chronic nausea and stomach pain. VERY INTOLERANT to pain -- complained of needing MORPHINE when his new shoes gave him blisters! Tears up/cries easily and never has dry mouth. His skin always feels warm, although he does dress in layers.

Hmmm . . . . ???



Sue

Yeah, even if this information isn't accepted by mainstream medicine, it sounds like there has to be something to it. All of the self treatment might be bogus though.

My father is the same way. His serotonin levels are low. He is manipulative, abusive, narcissistic, unfaithful, etc.

http://en.wikipedia.org/wiki/Antisoc...ality_disorder

His mother is diagnosed ADD (my grandmother), I'm sure of it. I told her that I believe I had ADD and she was like, "God must have told you this". So that made me sure of it.

The thing is, her mood disorder caused her to place unreasonable restrictions on her already susceptible children. A forced living environment, as children, will cause ODD/APD (from what I've been reading).

My father went to a psychiatrist and was placed on all the medicines (from SSRI to antipsychotics). And none of them worked for him (according to him).

I just think that his paranoia, sleep apnea, concurrent panic attacks, lack of follow through, deception to the psychiatrist, initial fluctuation of SSRI benefits, and oppositional/antisocial behavior led him to not get to the point where SSRI's could help him.

[sloppitty-sue]

Hobbledehoy:

My father is the same way. His serotonin levels are low. He is manipulative, abusive, narcissistic, unfaithful, etc.

Geez H.H. My heart goes out to you. I've read that growing up with such a parent most often results in extreme emotional/mental/psychological pain that can be difficult to overcome, even into adulthood. I believe I've lived with something similar. So sorry to hear this about your father.

Just curious: What was your mom like? (That is, if you're in the mood. I understand if you'd rather not get into it.)




Sincerely,
Sue

[Hobbledehoy]

Originally Posted by sloppitty-sue

Hobbledehoy:


Geez H.H. My heart goes out to you. I've read that growing up with such a parent most often results in extreme emotional/mental/psychological pain that can be difficult to overcome, even into adulthood. I believe I've lived with something similar. So sorry to hear this about your father.

Just curious: What was your mom like? (That is, if you're in the mood. I understand if you'd rather not get into it.)




Sincerely,
Sue

The only thought ailing my mind currently is whether or not I'm going to get another job So no worries. My mother is kind. She worked a lot while I was growing up. She had to in order to keep a roof over our head. My father has always been unstable with employment.

[choetso]

One of the most interesting new perspectives I have encountered. I remember histidin from my days, but never concentrated on it, as my field was serotonine.
But there are connections.
Also my field turned out to be neuroactive urine peptides, like caseomorphines (from milk protein casein), an "exorphine" proline-rich peptide family involved in schizophrenia/psycosis, autism, etc.
They bind to the morphine receptors so you can get addicted to milk and so on ;-) milk junkies?
I also investigated a urine peptide from AD/DH, small (like really really small) concentrations of it stimulating serotonine uptake in blood platelets in vitro. What could be the effect of this in the brain/nerve synapses?

Casein and gluten and some other foodstuffs (spinach!) contain proline-rich peptide sequences. Opioid peptide sequences.