ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community  

Go Back   ADD Forums - Attention Deficit Hyperactivity Disorder Support and Information Resources Community > SCIENTIFIC DISCUSSIONS, RESEARCH, NEWS AND EVENTS > Current ADD Events & News > ADD News
Register Blogs FAQ Chat Members List Calendar Donate Gallery Arcade Mark Forums Read

ADD News News from around the world about ADD/ADHD, other disorders, and some rather bizzarre & strange stories.

Reply
 
Thread Tools Display Modes
  #1  
Old 06-24-09, 02:40 PM
APSJ's Avatar
APSJ APSJ is offline
Nondescript Moderator
 

Join Date: Mar 2009
Location: New York
Posts: 3,867
Thanks: 10,532
Thanked 6,572 Times in 2,694 Posts
APSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond reputeAPSJ has a reputation beyond repute
New Study of Genetics of ADHD

ADHD Genes Found; Known to Play Roles in Neurodevelopment

Quote:
Pediatric researchers have identified hundreds of gene variations that occur more frequently in children with attention-deficit hyperactivity disorder (ADHD) than in children without ADHD. Many of those genes were already known to be important for learning, behavior, brain function and neurodevelopment, but had not been previously associated with ADHD.
Quote:
"When we began this study in 2003, we expected to find a handful of genes that predispose a child to ADHD," said study co-leader Peter S. White, Ph.D., a molecular geneticist and director of the Center for Biomedical Informatics at Children's Hospital. "Instead, there may be hundreds of genes involved, only some of which are changed in each person. But if those genes act on similar pathways, you may end up with a similar result -- ADHD. This may also help to explain why children with ADHD often present clinically with slightly different symptoms."
Quote:
Among 222 inherited CNVs found in ADHD families but not in healthy subjects, a significant number were in genes previously identified in other neurodevelopmental disorders, including autism, schizophrenia and Tourette syndrome. The CNVs found in ADHD families also altered genes important in psychological and neurological functions such as learning, behavior, synaptic transmission and nervous system development.
This study seems to lend support the idea that ADHD isn't caused by a single, or even a few, factors. As the article says, it seems quite consistent with the fact that people experience it so differently from one another. I would imagine that it could also start to explain why some people report such positive results from different supplements, while others find them useless, and differing responses to medications.

The fact that these genes are known to be involved with other disorders could also explain why its sometimes so hard to distinguish between ADHD and other conditions, and for people with co-morbidities to know what symptom goes with what diagnosis. If it turns out that the genetic causes of different disorders are better understood as clusters of genes with significant overlap between them, then assigning a symptom caused by a gene that fits into the clusters for two disorders, to one or the other, in a person who has both, would be arbitrary.

I would be interested to see more specifics. For example, I wonder if there were any genes that occurred in virtually all people with ADHD or genes that occurred in virtually none? I would read the study, but I've had poor success deciphering scientific journal articles on genetics.

Quote:
Another deletion occurred in a gene for a glutamate receptor. Glutamate is a neurotransmitter, a protein that carries signals in the brain. While ADHD medications act on dopamine and serotonin, which are also neurotransmitters, this new finding may suggest an important role for glutamate as well, at least for some ADHD patients.
This finding struck me as potentially having implications beyond whats stated in the article, but I'm not really sure why or what they would be. Can anyone help?
Reply With Quote
The Following 5 Users Say Thank You to APSJ For This Useful Post:
Annwn (06-24-09), Dizfriz (06-25-09), Fierwing (06-27-09), kattsqueen (06-26-09), Mincan (06-24-09)
  #2  
Old 06-25-09, 09:33 AM
Dizfriz Dizfriz is offline
ADDvanced Forum ADDvocate
 

Join Date: Aug 2007
Location: Texas
Posts: 4,114
Thanks: 15,830
Thanked 10,438 Times in 3,291 Posts
Dizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond reputeDizfriz has a reputation beyond repute
Re: New Study of Genetics of ADHD

APSJ
Good find.

While genetics is *very* much not my field, I keep up enough to understand that this research is important but not overly surprising in that we have known for a while that ADHD is a complex poly genetic disorder with a variable and also complex set of expressions and causations. It appears that we continue to get deeper into the details of the genetic base for ADHD.

As to the implications, we will have to wait until the scientific process digests it. It will have to be replicated, tested and most importantly evaluated on how the research suggested by this turns out.

The impact of the suggested research will be the most important factor in evaluating it's importance. In my view, this study will be a driver for a lot of research grants and may well turn out to be of major importance. Time will tell.


Overall, neat stuff. Thanks for posting it.

Dizfriz
Reply With Quote
The Following User Says Thank You to Dizfriz For This Useful Post:
APSJ (06-25-09)
  #3  
Old 06-25-09, 10:12 PM
kattsqueen kattsqueen is offline
ADDvanced Contributor
 

Join Date: Feb 2009
Location: on the banks of the wabash river
Posts: 581
Thanks: 470
Thanked 194 Times in 151 Posts
kattsqueen is just really nicekattsqueen is just really nicekattsqueen is just really nicekattsqueen is just really nice
Re: New Study of Genetics of ADHD

http://www.neurotransmitter.net/adhdglutamate.html

I found this and bookmarked it last week.I too have trouble following the research but here is some more for you,,
katts
Reply With Quote
The Following User Says Thank You to kattsqueen For This Useful Post:
APSJ (06-26-09)
Sponsored Links
  #4  
Old 06-25-09, 11:30 PM
PedroDaGr8 PedroDaGr8 is offline
ADDvanced Contributor
 

Join Date: Jun 2009
Location: San Diego, CA
Posts: 576
Thanks: 48
Thanked 281 Times in 178 Posts
PedroDaGr8 is a glorious beacon of lightPedroDaGr8 is a glorious beacon of lightPedroDaGr8 is a glorious beacon of lightPedroDaGr8 is a glorious beacon of lightPedroDaGr8 is a glorious beacon of light
Re: New Study of Genetics of ADHD

A little bit about what they are looking at:

SNPs - Single Nucleotide Pairs. For example:
A-T is an SNP. as is T-A, C-G and G-C. This basically means, one nucleotide and its matched partner on the opposite strand. So an example of an SNP mutation would be:

Normal
ATCGGCTA
TAGCCGAT

SNP change:
AACGGCTA
TTGCCGAT


WHat they were looking at the CNV deal with streches of repeated sequences.

For example:

---ACTGTGCTAACTGTGCTAACTGTGCTAACTGTGCTAACTGTGCTA---
---TGACACGAT
TGACACGATTGACACGATTGACACGATTGACACGAT---

I have bolded ever other repeating unit for clarities sake. THe --- indicate that the Genes continue on at either side.

A CNP change would be a change in the number of repeating units either more or less.

---ACTGTGCTAACTGTGCTAACTGTGCTAACTGTGCTA---
---TGACACGAT
TGACACGATTGACACGATTGACACGAT---

This would be a CNP change.

There are a WIDE number of ways this can affect the genes expression. For example, it maybe, four identical proteins are synthesised continuously and combined in a tetramer (four parts bound together as one) to make the ACTIVE protein. Delete one of these repeating units and you now only have three of the proteins made so your protein is no longer active as it is a trimer.
Reply With Quote
The Following 3 Users Say Thank You to PedroDaGr8 For This Useful Post:
APSJ (06-26-09), Dizfriz (06-26-09), kattsqueen (06-26-09)
Reply

Bookmarks


Currently Active Users Viewing This Thread: 1 (0 members and 1 guests)
 
Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is On
Forum Jump

Similar Threads
Thread Thread Starter Forum Replies Last Post
Dodgy diagnosis? (long rant/post) tribalsushi Adult Diagnosis & Treatment 9 09-07-13 01:34 AM
Amphetamines and Memory Bruce General Medication Discussion 18 07-25-05 09:56 PM
Adderall & Valproate for Bi-polar ADHD Children - Abstract from a recent study Gregster ADD News 0 12-30-04 01:07 PM
Datamonitor: ADHD Children Not Coming to Attention of Parents and Teachers Andi ADD News 0 10-27-04 04:37 PM
A Research Study for Children with Attention-Deficit/ Hyperactivity Disorder (ADHD) Andrew New York 0 06-19-04 11:31 AM


All times are GMT -4. The time now is 11:42 AM.


Powered by vBulletin® Version 3.7.4
Copyright ©2000 - 2018, Jelsoft Enterprises Ltd.
(c) 2003 - 2015 ADD Forums